Autosomal dominant osteopetrosis (ADO) is a sclerotic bone disorder due to failure of osteoclasts. ADO poses difficulties during arthroplasty because of the increased chance for iatrogenic fractures due to sclerotic bone. ADO is divided into two types based on radiological findings, fracture risk, and osteoclast activity. These differences suggest less brittle bone in patients with ADO I compared to that of patients with ADO II, which suggests a smaller chance of preoperative fractures during cementless arthroplasty in ADO I compared with that in ADO II. A case of cementless total knee arthroplasty in a patient with ADO I is presented. Total hip arthroplasty was performed during follow-up, and known major problems related to ADO II were experienced. Therefore, the differences between ADO I and ADO II may not be clinically relevant for an iatrogenic fracture during arthroplasty in patients with ADO.
Acetabulum/injuries ; Adult ; Arthroplasty, Replacement, Knee/*adverse effects ; Down Syndrome/complications ; Female ; Femoral Fractures/etiology/surgery ; Genes, Dominant ; Humans ; Iatrogenic Disease ; Knee Joint/surgery ; Osteoarthritis, Knee/complications/*surgery ; Osteopetrosis/complications/*surgery ; Periprosthetic Fractures/*etiology/surgery ; Tibial Fractures/etiology/therapy

Intramedullary interlocking nailing is the gold standard for treatment of tibial shaft fractures. The growing use of intramedullary nailing has resulted in an increased number of tibial nailing in daily clinical practice. Despite adequate surgeon experience, tibial nailing is not without complications if proper techniques are not followed. A case of iatrogenic talar neck and medial malleolus fractures during intramedullary nailing of tibia in a 24-year-old male is reported. It is believed to be caused by forceful hammering of insertion zig with foot dorsiflexed. To the best of our knowledge, no such case has been reported in the literature. It is possible to reduce the risk of this complication by adoption of preventive measures.
Ankle Fractures ; Bone Nails ; adverse effects ; Femoral Fractures ; surgery ; Fracture Fixation, Intramedullary ; adverse effects ; instrumentation ; Fractures, Bone ; diagnosis ; etiology ; therapy ; Humans ; Iatrogenic Disease ; Male ; Talus ; injuries ; Tibial Fractures ; surgery ; Tomography, X-Ray Computed ; Young Adult

INTRODUCTIONInfection following grade IIIB open tibial fracture is common. The primary aim of managing this condition is to achieve control of infection before the bone reconstruction procedure is performed. The outcomes for such patients have not been evaluated in the literature. This study was conducted to examine the outcome of a multi-stage procedure for the treatment of infected grade IIIB open tibial fractures.

METHODSBetween 2004 and 2008, we treated 11 patients with infected grade IIIB open tibial fractures in our unit. The management of infected grade IIIB open tibial fracture comprised three stages, which included serial debridement, wound closure by local flap surgery and bone reconstruction. The margin of resection and the type of bone reconstruction depended on the anatomical location of the disease, the extent of osteomyelitis and patient preference regarding treatment options. Bone reconstruction procedures included bone grafting, plating, interlocking nail, hybrid and monolateral external fixator, and Ilizarov bone transport.

RESULTSGram-negative organisms were isolated from all patients. Pseudomonas aeruginosa (P. aeruginosa) (44%) was the most common organism cultured. Infection was resolved in all patients. Nine fractures achieved union, with a mean union time of 15 months. Two patients with P. aeruginosa infection developed non-union of the fracture and refused additional surgery after three years of treatment.

CONCLUSIONThe multi-stage management approach is well-accepted and effective in controlling infection in infected grade IIIB open tibial fractures.

Adult ; Aged ; Aged, 80 and over ; Debridement ; methods ; Female ; Fracture Fixation ; methods ; Fractures, Open ; complications ; surgery ; Fractures, Ununited ; surgery ; Humans ; Ilizarov Technique ; Malaysia ; Male ; Middle Aged ; Osteomyelitis ; etiology ; microbiology ; surgery ; therapy ; Prospective Studies ; Surgical Flaps ; Tibial Fractures ; complications ; surgery ; Treatment Outcome ; Wound Infection ; etiology ; microbiology ; surgery ; therapy