The skin is rich in nerve terminals, among which autonomic nerves closely interact with keratinocytes and immune cells. The autonomic nerves are critical to skin physiological function. Patients with atopic dermatitis exhibit reduced autonomic innervation, accompanied by autonomic nerve dysfunction such as sweating disorder. Restoration of autonomic neurological function can ameliorate atopic dermatitis. This review summarizes the structure and physiological function of skin autonomic nerves, autonomic neurological abnormalities in atopic dermatitis, and possible therapeutic strategies.

Objective To understand the trends and characteristics of clinical trials on cancer pain medications in recent years,and to provide a reference basis for the development and clinical research of cancer pain medications.Methods Relevant information on clinical trials of cancer pain medications from 1987 to 2022 was retrieved from the ClinicalTrials.gov database,and a descriptive analysis was conducted from the perspectives of trial types,registration dates,reporting regions,cancer pain type,and cancer pain medications.Results A total of 376 clinical trials were selected,Among them,the number of investigator-initiated trials(IIT)was greater than that of industry-sponsored trials(IST).North America had the highest total number of projects,IIT and IST projects.The total number of trials and IST projects increased first and then decreased,while the number of IIT trials steadily increased.There was relatively higher amount nof research focused on chronic cancer pain,breakthrough cancer pain,and severe cancer pain.The highest proportion of subjects studied were opioids,with fentanyl being particularly prominent among them.Conclusion Clinical trials of cancer pain medications have played an important role in advancing cancer pain medication,but there is a need to further strengthen IST research on novel cancer pain medications and conduct more IIT studies to better optimize cancer pain treatment outcomes.