ObjectiveTo investigate the impact of different infusion methods on the incidence of Cinobufagin-induced phlebitis. Methods80 patients required Cinobufagin infusion were enrolled and were randomized into the observation group and the control group with 40 patients in each group.In the observation group,low dose of phentolamine was added into the Cinobufagin solution.Normal saline was infused into patients before,during and after the course of the Cinobufagin infusion.For the control group,low dose of phentolamine was added into the Cinobufagin solution without normal saline infusion.The incidence of phlebitis was compared between two groups. ResultsThe incidence of phlebitis in the observation group was 27.5％,and the control group was 60.0％.The difference was statistically significant. ConclusionsPhlebitis induced by Cinobufagin-infusion can be prevented by addition of low dose of phentolamine and infusion of normal saline solution before,during and after the course of Cinobnfagin infusion.