1.Sequential generation of anti-M and anti-Jka leads to two delayed hemolytic transfusion reactions and corresponding strategies
Honghui LONG ; Yingying NIU ; Danting WANG ; Chunyan HUANG
Chinese Journal of Blood Transfusion 2024;37(5):501-505
【Objective】 To make transfusion management strategies for patients with history of blood transfusion and/or pregnancy by following up a patient with delayed hemolytic transfusion reactions(DHTR) caused by unexpected antibody produced after blood transfusion. 【Methods】 ABO, Rh, MN and Kidd blood group test, direct antiglobulin test, unexpected antibody screening, antibody identification, antibody titer detection, and cross-matching test were performed on a patient with DHTR. Meanwhile, suitable red blood cells were screened for subsequent treatment. 【Results】 The patient′s blood group was B, RhD(+ ) and CCDee, the antibody screening test and cross-matching test were negative before the first transfusion. After eight days, hemoglobin of the patient decreased to 57 g/L and the laboratory results indicated delayed hemolysis, the antibody screening was positive, and the antibody identification result was anti-M, as RBCs of the patient received typed as M+ N+. After the patient received M antigen negative RBCs, the laboratory test results still indicated delayed serologic transfusion reaction. A new antibody arose and was identified as anti-Jka while RBCs transfused were M-N+ and Jk(a+ b-). Afterwards, it was effective for the patient to receive B, RhD(+ ), M-N+ and Jk(a-b+ ) RBCs. 【Conclusion】 Most of the homologous antibodies produced by patients after blood transfusion will disappear within a few years. When patients undergo another transfusion, DHTR may occur because of anamnestic reaction. Establishing a transfusion management document and creating a card for patients who have already produced RBC alloantibodies can greatly reduce the occurrence of DHTR by informing doctors and staff when the next transfusion is needed.
2.Treating Recurrent Angina Pectoris After Percutaneous Coronary Intervention based on Qi and blood Vessels
Mengran LI ; Yongyuan CAI ; Zhongmin YAN ; Tianfu NIU
Journal of Traditional Chinese Medicine 2024;65(12):1245-1248
This paper discussed the pathogenesis and treatment ideas of recurrent angina pectoris after percutaneous coronary intervention (PCI) based on qi and blood vessels. It is believed that patients after PCI often have poor qi and blood circulation and damaged vessels and collaterals as the basis, and subsequently suffer from binding of phlegm and stasis, accumulated and sticky, which further lead to the vessels congested and blocked, qi and blood declined, and the body and functions of the heart damaged. Accordingly, in terms of the treatment principles, it has been proposed to regulate qi and transport blood, unblock and nourish vessels, dissolve phlegm and dispel stasis, direct turbidity downward and unblock collaterals, supplement qi and nourish the body, unblock vessels and rejuvenate meridians, by using self-made Tiaoqi Yunxue Formula (调气运血方), self-made Huoxue Jiangzhuo Formula (活血降浊方) and self-made Shenrong Tongmai Formula (参茸通脉方) in their modifications respectively, in order to provide reference for clinical diagnosis and treatment.