1.Transcatheter arterial chemoembolization combined with 3-dimensional conformal radiotherapy for primary hepatic carcinoma
Zemin XIAO ; Tiancheng OUYANG ; Ruizhen YU ; Xiaosong JIANG ; Huan REN ; Xiaohua LIU
China Oncology 2000;0(06):-
Background and purpose:Hepatocellular carcinoma(HCC) is one of the most common malignancies in the world,It has a poor prognosis due to its rapid infiltrating growth and complicating liver cirrhosis.Surgical resection is considered the best curative option,the 5-year survival rate could reach 50%,especially in the patients with lesions less than 5 cm in diameter and good residual liver function.However curative surgery is feasible for only about 20% of patients.Transcatheter arterial chemoembolization(TACE) has been demonstrated that its short-term curative effect is better than the other nonsurgical treatments.However,it has not provided any survival benefit.Many studies have been done to improve the overall therapeutic effects of HCC with multi-modality approaches.The purpose of our trial was to evaluate the effects of TACE combined with 3-dimensional conformal radiation therapy(3-DCRT) for primary hepatic carcinoma.Methods:90 patients with primary hepatic carcinoma were randomly divided into two groups :45 were treated with 3-DCRT plus TACE and the others were treated with TACE alone.For TACE,80-120 mg cisplatin and 1 000 mg 5-Fluorouracil or 30 mg hydroxycamptothecine)were perfused into the hepatic arteries,then 50-100 mg adriamycin(or epirubicin) or 16 mg mitomycin C and iodized oil 10-30 ml were given to embolize the hepatic arteries,and followed by 1-2 mm gel form particles.TACE of 1-3 sessions was given to both groups.For the combined group,3-DCRT was given by 6MV X-ray.The patients with planned target volume(PTV) lesser than 512 cm~(3) received a total dose of 45-56 Gy,4.5-7 Gy per fraction,and the patients with PTV larger than 512 cm~(3) received a total dose of 45-56 Gy,2.5-4.5 Gy per fraction,5 times every week.Results:The response rates (CR+PR)of 3-DCRT plus TACE group and TACE alone group were 91.1% and 60%,respectively(?~(2)=11.79,P
2.Effects of intervention based on WeChat on blood pressure control in patients with hypertension:Meta-analysis
Luhua YU ; Yan LIU ; Miaoling HUANG ; Junyan LI ; Qian GUO ; Chong MAN ; Tiancheng ZHANG
Journal of Preventive Medicine 2019;31(9):891-896
Objective:
To evaluate the effects of the intervention based on WeChat on blood pressure control in patients with essential hypertension.
Methods:
The databases of CNKI,Wanfang,VIP,PubMed and the Cochrane Library were researched for the literatures about effects of the intervention based on WeChat on blood pressure control in patients with essential hypertension published from 2011 to 2018. These papers were retrieved and evaluated according to inclusion and exclusion criteria. Stata 12.0 software was used for meta analysis.
Results:
Eleven out of 880 papers were included into meta analysis. There were 1 174 cases,with 587 cases in the experimental group and 587 cases in the control group. The results of the meta analysis showed that compared with traditional health intervention method,the intervention based on WeChat significantly reduced the level of systolic blood pressure(WMD=14.77,95%CI:11.76-17.77)and diastolic blood pressure(WMD=8.17,95%CI:5.67-10.67)of hypertensive patients. Subgroup analysis showed that the longer the intervention,the better the effects(P<0.05).
Conclusion
The intervention based on WeChat is more helpful than traditional health intervention for blood pressure control of patients with essential hypertension.
3.Application of intelligent performance measurement system for gastrointestinal endoscopy to colonoscopy
Tiancheng YU ; Liwen YAO ; Ming XU ; Zhifeng ZHAO
Chinese Journal of Digestive Endoscopy 2021;38(10):795-800
Objective:To evaluate the intelligent performance measurement system for colonoscopy.Methods:Nine endoscopists from Renmin Hospital of Wuhan University were randomly assigned to the quality control group and the control group based on inclusion and exclusion criteria by the random number table. In the pre-quality-control stage (from April 20, 2019 to May 30, 2019), colonoscopic data acquired by the enrolled endoscopists were collected. In the training stage (June 1-30, 2019), the quality control group was trained on the quality control knowledge and the use of intelligent gastrointestinal endoscopy performance measurement system; but the control group was only trained on the quality control knowledge.In the post-quality-control stage (from July 1, 2019 to August 20, 2019), a weekly quality feedback was given to endoscopists of the quality control group, while the endoscopists of the control group had no quality control report.Then, the colonoscopic data acquired by enrolled endoscopists were prospectively collected during the period. The primary endpoint was adenoma detection rate. The secondary endpoints were withdrawal time, polyp detection rate and cecal intubation rate.Results:Four endoscopists were assigned to the quality control group and five to the control group. A total of 1 471 colonoscopic procedures were analyzed. The detection rates of adenoma and polyp in the quality control group increased with feedbacks[13.7% (45/329) VS 7.1% (24/338), χ2=55.796, P<0.001; 48.9% (161/329) VS 40.2% (136/338), χ2=4.071, P=0.044], while there were no significant differences in the control group [9.3% (37/398) VS 9.1% (37/406), χ2=0.329, P=0.566; 33.9% (135/398) VS 33.0% (134/496), χ2=3.616, P=0.057]. The withdrawal time in the quality control group increased with feedbacks[5.9 (3.9, 7.3) min VS 4.1 (2.8, 6.1) min, Z=6.965, P<0.001], while there was no significant difference in this variable in the control group [3.9 (2.7, 6.1) min VS 3.6 (2.6, 5.8) min, Z=1.355, P=0.175]. Conclusion:The intelligent performance measurement system for gastrointestinal endoscopy with feedbacks can monitor and improve the colonoscopic quality.
4.Study on the biological exposure limit of whole blood chromium in occupational hexavalent chromium compounds exposed population
Guiping HU ; Yali ZHANG ; Shiyi HONG ; Zekang SU ; Qiaojian ZHANG ; Li WANG ; Tiancheng WANG ; Shanfa YU ; Guang JIA
China Occupational Medicine 2024;51(2):129-137
ObjectiveTo analyze the exposure-response relationship of peripheral whole blood chromium level and lung function as well as genetic toxicity indicators in workers exposed to hexavalent chromium [Cr(Ⅵ)] compounds, and to propose a biological exposure limit of whole blood chromium for soluble Cr(Ⅵ) compounds-exposed workers. Methods A total of 515 workers from a dynamic occupational Cr(Ⅵ) compounds-exposed cohort in an enterprise from 2010 to 2017 were selected as the research subjects using a retrospective cohort study. A total of 918 followed-up results of research subjects and baseline data of a cohort were analyzed based on bibliometric analysis. The results include lung function tests, whole blood chromium level detected by inductively coupled plasma-mass spectrometry, urinary 8-hydroxy-2′-deoxyguanosine (8-OHdG) detected by high performance liquid chromatography-tandem mass spectrometry, peripheral micronuclei frequency (MNF) detected by cytokinesis-block micronucleus assay, and mitochondrial DNA copy number (mtCN) detected by real-time fluorescence quantitative polymerase chain reaction. Results The results of bibliometric analysis showed that domestic and foreign studies on biological monitoring of Cr(Ⅵ) compounds increased year by year in the past 30 years, and whole blood chromium levels had a good correlation with the occupational Cr(Ⅵ) compounds exposure. The geometric mean of whole blood chromium levels in males and females among the occupational Cr(Ⅵ) compounds exposure cohort was 2.77 and 1.79 μg/L, respectively. A turning point appeared in 6.00 μg/L chromium in whole blood of the exposure-response curve of whole blood chromium levels with lung function indicators and genetic toxicity indicators. For each unit increase in the natural logarithm-transformed whole blood chromium level, the forced expiratory volume in one second (FEV1) decreased by 0.05 L, the FEV1/forced-vital-capacity decreased by 0.67%, the peak expiratory flow decreased by 0.15 L/s, the maximal mid-expiratory flow decreased by 0.09 L/s, the MNF increased by 0.149‰, the urinary 8-OHdG increased by 0.090 μg/g, and the mtCN increased by 0.013. When the whole blood chromium level was >6.00 μg/L, there was a significant increase in urinary 8-OHdG, MNF, and mtCN (all P<0.01). Conclusion The level of whole blood chromium can be used as a biomarker for occupational exposure to soluble Cr(Ⅵ) compounds. The preliminary biological exposure limit is set at 6.00 μg/L for whole blood chromium in workers exposed to soluble Cr(Ⅵ) compounds.
5.Analysis of the relationshiop and mediating factors between sleep quality and emotional regulation difficulties in millde school students
Chinese Journal of School Health 2024;45(7):1008-1011
Objective:
To explore the relationship of sleep quality and emotional regulation difficulties in middle school students, and to analyze its mediating role of daytime dysfunction, social rejection and selfcontrol ability, so as to provide a scientific reference for improving middle school students mental health.
Methods:
From October to November, 2023, the Pittsburgh Sleep Quality Index, Adolescent Social Rejection Questionnaire, Brief Selfcontrol Scale and Difficulties in Emotion Regulation Scaleshort Form (DERS-16) were used to assess 806 students recruited from four middle schools in Bengbu City by a convenient cluster random sampling method. And model-6 of PROCESS and 5 000 Bootstraps were used to make a chainmediating model analysis.
Results:
Daytime dysfunction was positively correlated with sleep quality(r=0.57), social rejection(r=0.19), selfcontrol(r=0.29, P<0.01). Selfcontrol was positively correlated with emotional regulation difficulties(r=0.54, P<0.01).Poor sleep quality showed a significant positive association with on daytime dysfunction, and daytime dysfunction further affected social rejection, selfcontrol ability and emotional regulation difficulties (β=0.86, 0.60, 1.27, 1.56, P<0.05). Meanwhile, daytime dysfunction, social rejection and selfcontrol played a serial mediating role in the relationship between sleep quality and emotional regulation difficulties (Estimate=0.11,95%CI=0.04-0.20,P<0.05).
Conclusion
The study reveals the complex relationship between sleep quality and emotional regulation difficulties in middle school students and provides a new theoretical basis for adolescent sleep improvement and mental health interventions.
6.Safety and effectiveness of hemoperfusion on the removal of uremic toxins in chronic kidney disease
Meng-yao AN ; Peng GE ; Lei HU ; Fei ZHONG ; Bo-yu ZHOU ; Chang-xiao LIU
Acta Pharmaceutica Sinica 2020;55(12):2924-2933
The goal of the present study was to determine the effectiveness and safety of hemoperfusion (HP) in beagle dogs with chronic kidney disease (CKD). The experimental protocol was approved by the Institutional Animal Care and Use Committee of Tianjin Institute of Pharmaceutical Research New Drug Evaluation Research (IACUC2019071501). Twelve CKD model beagles were randomly divided into two groups: a low-frequency treatment group (
7.Development of functioning and community-based rehabilitation protocol for drug dependent population using ICF
Chinese Journal of Rehabilitation Theory and Practice 2022;28(10):1150-1158
ObjectiveTo analyze the mental health and functional status of drug-dependent population by applying the theory and method of International Classification of Functioning, Disability and Health (ICF), explore the physical activity on the mental health pattern of drug-dependent population, and construct a theoretical framework, rehabilitation protocol and implementation plan for home exercise rehabilitation. MethodsThe International Classification of Diseases (ICD-11) and ICF were used to systematically analyze the physical dysfunction (cognitive and motor), activity and participation of drug-dependent population. Based on the ICF bio-psycho-social model of functioning, disability and health, and with reference to the WHO Guidelines on Physical Activity and Sedentary Behavior, a home exercise rehabilitation program was constructed for the functional rehabilitation of drug-dependent population. ResultsFunctional impairment in the drug-dependent population was manifested in the physical function element mainly in mental dysfunction (b1), impaired cognitive function, reduced emotional control, impaired memory function, slowed thinking and personality disorders; while long-term drug use triggered a series of comorbidities, mainly in cardiopulmonary function (b4) and partial impairment of motor function (b7); and in the activity and participation element, learning and applying knowledge (d1), general tasks and demands (d2), self-care (d5), interpersonal and intrapersonal interactions (d7), and community, social, and civic life (d9) were limited. Physical activity was beneficial for the drug-dependent population to improve mental health, including cognition, attention, emotion, and thinking. A function-based exercise rehabilitation protocol was established. It recommended a programe of moderate intensity aerobic exercise, including walking, Tai Chi, Yoga, etc., four to five times a week for 150 to 300 minutesp; or high intensity aerobic exercise, including running, rope skipping, badminton, table tennis, martial arts, etc., two to three times a week for 75 to 150 minutes; moderate-intensity or high-intensity resistance exercises, such as push-ups, pull-ups, sit-ups and other major muscle group activities, two to three times a week with 30 to 60 minutes per time. The program of home exercise rehabilitation for drug-dependent population should be integrated into the four aspects of prevention, treatment, rehabilitation and health promotion in the community health service continuum, and provide home exercise rehabilitation services through offline guidance (professional guidance, group guidance, self-guidance) and online guidance (video instruction, remote online guidance, cloud supervision). ConclusionA systematic analysis of the health condition and functional status of drug-dependent population has been conducted using ICD-11 and ICF, and a functional-oriented and holistic health-based home rehabilitation protocol has been developed based on the ICF bio-psycho-social model of functioning, disability and health, which may promote the recovery of cognitive, motor, activity, and participation functions of drug-dependent population, and help them reintegrate into family and society.
8.Metabolism of four diterpenoids of Euphorbia fischeriana in liver microsomes of rats
Tiancheng MA ; Yukun MA ; Jia SUN ; Jinling ZHANG ; Lina GUO ; Qi LIU ; Yu SUN
China Pharmacy 2022;33(4):465-472
OBJECTIVE To study the metabolites of four diterpenoids of Euphorbia fischeriana in liver microsomes of rats and to investigate its metabolic regularity. METHODS In vitro incubation system of liver microsomes of rats was built. The jolkinolide A,jolkinolide B ,17-hydroxyl jolkinolide A and 17-hydroxyl jolkinolide B were added into incubation system of liver microsomes in rats activated by reduced nicotinamide adenine dinucleotide phosphate ,incubated at 37 ℃ for 30 min,and then terminated the reaction with acetonitrile. Taking the negative group (adding acetonitrile firstly and then starting incubation for 30 min)as the reference,the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry was used ;Anaylyst®TF 1.7.1、PeakView® 2.2,MetabolitePilot 1.5 and MasterView 1.2 software were used to speculate and identify the fragmentation law of mass spectrometry and metabolites. RESULTS Four diterpenoids were easy to lose neutral fragments such as H 2O and CO in secondary mass spectrometry. Jolkinolide A and 17-hydroxyl jolkinolide A showed similar metabolism pathway ,including dihydroxylation,dehydrogenation,and monohydroxylation ;six and five metabolites were identified respectively. Jolkinolide B and 17-hydroxyl jolkinolide B showed similar metabolism pathway ,including monohydroxylation ,hydration and isomerization. Five metabolites were identified. CONCLUSIONS Both jolkinolide A and 17-hydroxyl jolkinolide A produce the metabolites of hydroxylation and dehydrogenation in liver microsomes of rats ;both jolkinolide B and 17-hydroxyl jolkinolide B produce the metabolites of hydroxylation ,hydration and isomerization in liver microsomes of rats. The metabolites of four diterpenoids are phase Ⅰ metabolites.
9.Analysis of Metabolites of Jolkinolide B in Rats by UPLC-Q-TOF/MS
Tiancheng MA ; Yu SUN ; Yukun MA ; Lei LIU ; Jia SUN ; Lina GUO ; Qi LIU
China Pharmacy 2019;30(20):2796-2801
OBJECTIVE: To analyze the metabolites of jolkinolide B in rats, and predict its metabolism pathway. METHODS: The rats were randomly divided into blank group (0.5% CMC-Na, ig) and administration group (jolkinolide B, ig, 100 mg/kg), with 8 rats in each group. The fecal samples were collected at >0-12, >12-24, >24-36 hours after administration; the urine samples were collected at >0-2, >2-8, >8-12, >12-24, >24-36, >36-48 hours after administration; the blood samples were collected at 1, 2, 8, 12, 24, 36 hours after administration. UPLC-Q-TOF/MS combined with Analyst® TF 1.7.1 and PeakView® 2.2 software were used to analyze and identify the metabolites in the samples after treated with ultrasonic extraction, solid phase extraction and protein precipitation. RESULTS & CONCLUSIONS: Prototype drugs and seven metabolites were detected in rat’s fecal samples, and one or two metabolites were detected in urine and blood samples, respectively. After intragastric administration, the metabolism of jolkinolide B in rats is mainly through ring opening, oxidation, dehydration, deoxygenation and hydrogenation of phase Ⅰ, but no phase Ⅱ metabolites were detected.
10.Research progress on improvement of functions of small molecular compounds of traditional Chinese medicine based on supramolecular properties of hyaluronic acid
Zhi-hua YUAN ; You-ting LIU ; Zhao-hui QU ; Xian-rong QIU ; Zhi-jia WANG ; Wen-min PI ; Xiao-yu LIN ; Peng-long WANG
Acta Pharmaceutica Sinica 2022;57(5):1245-1251
Hyaluronic acid is widely used in biomaterials, cosmetics, clinical medicine and other fields due to its good biocompatibility, degradability, hydrophilicity, tumor targeting, viscosity and other characteristics. Pharmacodynamic activities of natural small molecular products which derived from traditional Chinese medicine (TCM) are significant, but their low solubility and poor targeting limit the clinical application. Based on supramolecular properties of hyaluronic acid, in this review, numerous studies were reviewed on the improvement of solubility, bioavailability, targeting and suitable dosage forms of small molecular compounds in TCM by domestic and foreign scholars using hyaluronic acid as carrier. It provides new ideas and inspirations for exploring the potential application value of small molecule compounds in TCM and even for the research and development of new drugs.