Autophagy ; Cervical Cord ; injuries ; Humans ; Magnetic Resonance Imaging ; Spinal Cord Injuries ; complications ; diagnosis ; pathology

Cytological Techniques ; methods ; Diagnosis, Computer-Assisted ; Female ; Humans ; Vaginal Smears ; methods

We proposed a multi-resolution-wavelet-transform based method to extract brainstem auditory evoked potential (BAEP) from the background noise and then to identify its characteristics correctly. Firstly we discussed the mother wavelet and wavelet transform algorithm and proved that bi-orthogonal wavelet bior5. 5 and stationary discrete wavelet transform (SWT) were more suitable for BAEP signals. The correlation analysis of D6 scale wavelet coefficients between single trails and the ensemble average of all trails showed that the trails with good correlation (> 0. 4) had higher signal-to-noise ratio, so that we could get a clear BAEP from a few trails by an average and wavelet filter method. Finally, we used this method to select desirable trails, extracted BAEP from every 10 trails and calculated the I-V inter-waves' latency. The results showed that this strategy of trail selection was efficient. This method can not only achieve better de-noising effect, but also greatly reduce the stimulation time needed as well.
Algorithms ; Brain Mapping ; Evoked Potentials, Auditory, Brain Stem ; Humans ; Wavelet Analysis

Objective To explore the curative effect of ursodeoxycholic acid in treatment of intrahepatic cholestasis of pregnancy (ICP) and the effect on total bile acid (TBA) in post partum fetal umbilical venous blood .Methods 30 patients with intrahepatic cholestasis of pregnancy who were admitted into the Hospital Affiliated to Sichuan Medical University during January 2014 to December 2014 were selected as the research objects and randomly divided into observation group and control group ,15 cases in each group.The observation group were given ursodeoxycholic acid tablets while control group were injected with ademetionine butanedisulfonate .The curative effect of two kinds of drugs in treatment of intrahepatic cholestasis of pregnancy was observed and the effect on total bile acid in post partum fetal umbilical venous blood was analyzed .ResuIts After treatment , the TBA and ALT of observation group were significantly lower than those pre-treatment and those of control group (P<0.05).There were no significant differences of TBIL and ALP between two groups and within groups.TBA and TBIL in post partum fetal umbilical venous blood of observation group were significantly lower than those of control group (P<0.05).There was no significant difference of ALT level between two groups .There were two cases of abnormal perinatal outcomes in observation group while seven cases in control group (χ2 =3.97, P<0.05).ConcIusion Ursodeoxycholic acid could effectively reduce the total bile acid levels in maternal and fetal umbilical vein blood, reduce the mortality rate of the fetal and improve the perinatal outcomes , with high security.

OBJECTIVE:To raise the price fixing of drugs to a scientific and reasonable level.METHODS:From the view of the whole society,the economic efficiency of newly-developed drugs and original drugs was compared with cost-effec?tiveness analysis.RESULTS&CONCLUSION:Through comparison,the price ranges with economic efficiency of newly-de?veloped drugs would be obtained,which could guide the price fixing.

OBJECTIVE:Using the result of pharmacoeconomic evaluation to instruct the management of drug prices.ME_ THODS:Establishing a reference price and combining economic benefit to decide the price of a drug.RESULTS&CONCLU_ SION:According to the rational value scope,the prices of new drugs can be fixed.A reasonable and timely adjustment of the price can be made.

There is a trackphenomenon in the development of hypertension and pediatric hypertension has an important predictive value for adult hypertension. However pediatric hypertension is not typical and normal blood pressure is associated with age,sex and height. The blood pressure level,clinical presentation and complication rates of secondary pediatric hypertension are higher than primary pediatric hypertension. So secondary pediatric hypertension could get timely treatment compared to primary pediatric hypertension. This paper focus on the clinical presentation and diagnosis criterion of pediatric hypertension and provide a reference for the pediatrician.

Objective The study was designed to investigate the effect of atomization inhalation of Qingjin-Huatandecoction on prevention of elderly patients’ postoperative pulmonary complications after thoracotomy.MethodsA total of 60 elderly patients with thoracotomy were randomized into 2 groups. Both groups of patients were treated with oxygen uptake, anti-infection, antispasmodic, analgesic, and nutritional support. Based on the conventional treatment, the control group was added with atomization inhalation of mucosolvan and dexamethasone, while the treatment group with atomization inhalation ofQingjin-Huatan decoction. The volume of phlegm, serum CRP, TNF-α level and absolute neutrophil count (ANC), arterial blood gasanalysis, and records of the pulmonary complications were meausred.Results The pH value at Day 3 (7.39 ± 0.06vs. 7.36 ± 0.05,t=2.120), the PaO2at Day 3 (86.51 ± 3.96 mmHgvs. 84.07 ± 3.51 mmHg,t=2.520) and Day 5 (92.27 ± 2.94 mmHgvs. 90.40 ± 3.08 mmHg,t=2.400) of treatment group were significantly higher than those of the control group; the PaCO2at Day 3 (44.57 ± 2.53 mmHgvs. 46.39 ± 3.35 mmHg,t=2.390) and  Day 5 (40.77 ± 2.48 mmHgvs. 42.42 ± 3.33 mmHg,t=2.130) of treatment group were significantly lower than those of the control group. The serum CRP at Day 3(8.26 ± 2.38 mg/Lvs. 9.76 ± 2.37 mg/L,t=2.440) and Day 5 (6.94 ± 1.76 mg/Lvs. 8.15 ± 2.38 mg/L,t=2.250), the ANC at Day 3 (8.54 ± 1.85)×109/Lvs. (9.58 ± 1.94)×109/L, t=2.140) and Day 5 (6.54 ± 1.85)×109/Lvs. (7.58 ± 1.95)×109/L,t=2.160), the serum TNF-a at Day 5 (7.54 ± 1.38 mg/Lvs. 8.43 ± 1.36 mg/L,t=2.540) of treatment group were significantly lower than those of the control group. The sputum volume at Day 3 (50.74 ± 18.46 ml/dvs. 59.92 ± 15.25 ml/d,t=2.099) and Day 5 (39.64 ± 18.21 ml/dvs. 48.99 ± 13.55 ml/d,t=2.256) of treatment group was lower than that of the control group. At Day 5, the pneumonia (3.33%vs. 20.00%,t=4.043) and the atelectasis (6.67%vs. 26.77%,t=4.320) of treatment group were significantly lower than those of the control group(P<0.05).ConclusionAtomization inhalation ofQingjin-Huatandecoction can improve pulmonary function of postoperative pulmonary complications of elderly patients after thoracotomy, take control of inflammation and the occurrence of postoperative pulmonary complications.

Objectives:To observe the effect of intrahepatic cholestasis on the development and growth of fetus in pregnant rats. Methods: The animal models of intrahepatic cholestasis were made by injecting benzogynestryl (5 mg/kg body weight) or cholate (2.4 mg/kg body weight) for 5 days starting from 16th day of pregnancy. Biochemical parameters of fetal plasma and amniocent were determined at the 21st day of pregnancy. The pathological lesion of placenta in rats was also observed. Results: Cholic acid group showed lower body weight and high level of estrodiol in fetal plasma with high metaphase mortality of fetus. The level of TBA in amniocent was high in estrodiol group compared with normal control group. Pathologically, placenta edema and chorion denaturalization and necrosis with infiltration of neutrocyte were observed in both groups. Conclusions: Intrahepatic cholestasis is detrimental to the development and growth of fetal rats in pregnancy rats.

The core problem of current rural health services is a governance problem, that is, how the basic rural health resources can be used more effectively. Based on the study of history and reality, this paper suggests that in the existing “government-market” framework, the village is the third perspective worthy of consideration. Inside the village community, the trust, network and cooperation between people which were based on the traditional rural acquaintances society capital and the institutional resources in the organizations at the primary level will be able to in-crease the degree of organization, thereby reducing the transaction costs between the government or the market and rural residents. The village power will be able to better take advantage of government and market mechanisms, and thus solve the problem of rural health resource utilization more effectively.