Humans ; Lymphohistiocytosis, Hemophagocytic ; Male ; Middle Aged

Objective To explore the control measures of drug induced liver disease.Methods The age,disease drugs,clinical manifestations,treatment and prognosis of 162 cases with drug induced liver disease were analyzed retrospectively.Results Drug induced liver disease incidence in different age groups are slightly more old age group,Lead to liver damage to many types of drugs,a common anti-TB drugs and other lipid-lowering medicine and Chinese herbal medicine and health drugs can not be ignored.Clinical performance of drug-induced liver disease is different,mostly had good prognosis after treatment,a few turn into cirrhosis,a very small number of fulminant hepatic failure or even death.Conclusion Avoid the use of the drug that may injure the liver,liver protection must also drugs should be regularly reviewed liver function.

Acute Disease ; Angioplasty, Balloon, Coronary ; adverse effects ; Compartment Syndromes ; etiology ; Female ; Humans ; Middle Aged

[Objective]To investigate the mechanism and pathologic changes of anterior cruciate ligament impingement syndrome as well as its arthroscopic diagnosis and treatment.[Method]From January 2005 to June 2007,28 patients with a history of anterior cruciate ligament impingement were diagnozed and treated arthroscopically.The patients' clinical findings were mainly anterior patellar pain and limited knee joint.The reasons of anterior cruciate ligament impingement syndrome were indentified by routine arthroscopic examination:straitness of intercondylar notch or osteophytes formation in 19 cases,old avulsion fracture in the tibial intercondylar in 4 cases,anterior cruciate ligament cyst in 3 cases,incorrect tibial tunnel placement on reconstructed anterior cruciated ligament in 2 cases.Different surgical procedures were carried out according to the results of the examination:joint debridement and intercondyle's plasty;intercondyle's plasty and osteophytes resection;joint debridement and ACL cysts resection;ACL tibial eminence insertion reconstruction were performed.[Result]Twenty-eight cases were followed for an average of 15 monthes(6-34 monthes).The rate of good to excellent was 82.1%,recurrence was observed in 1 case.[Conclusion]The gradual constriction of the knee is mainly caused by the anterior cruciate ligament impingement syndrome.Arthroscopy is very valuable in diagnosis and treatment of anterior cruciate ligment impingement syndrome.It can also acquire whole assessment of the joint injuries and makes out reasonable treatment program to normal knee joint function.

Various pathologic mechanisms and types of lesion have participated in cognitive impairment in patients with vascular dementia.A number of medications have been used in the treatment of patients with vascular dementia in clinical practice,including cholinesterase inhibitors, N-methy-D-aspartate receptor antagonists,calcium channel blockers and neurotrophic drugs. This article reviews the progress in research on the pharmacotherapy of vascular dementia.

Objective: To prepare the calcitonin oral microparticle. Methods: The oral delivery system of salmon calcitonin was made using diketopiperazine microparticles as carrier by the method of sole solifification. The parameters including the shape of microparticle,dissolving in vitro , the effect of reducing bleed calcium and bioavailability etc . were observed. Results: The diameter of the microparticles was 1 3 ?m, and the drug concentration was 0.42%. The rate of encapsulating was 91.1%. The drug did not release within 2 h in artificial gastric fluid and completely released in artificial intestinal fluid within 6 h. The microparticles had obvious effect of reducing bleed calcium 3 h after it was taken, the effect lasted for 12 h. Conclusion: The microparticles of salmon calcitonin release slowly and have better effects of reducing bleed calcium by oral delivery system.

Objective To evaluate the feasibility, safty and methology of transradial coronary angiography Methods Transradial coronary angiography was carried out in 304 patients Results Transradial coronary angiography and ventriculography were successful in 291 patients (95 7%) Conclusion Radial artery seems to be both feasible and safe for coronary angiography, with a very low risk of local complication and more comfort for patients

Objective To investigate the inhibitory mechanism of rabeprazole on acid secretion of parietal cells in rats. Methods Seventy two Spraque-Dawley rats were divided into control group(normal saline), low dose of rabeprazole group (rabeprazole 10 mg/kg) and high dose of rabeprazole group (rabeprazole 20 mg/kg) with 24 each. Four rats in each group were treated at 1 h, 2 h, 4 h, 6 h, 12 h and 24 h, respectively, pH value and activity of H+-K+-ATPase were tested by NaOH titrimetric method and chromatometry, respectively. The changes of ultrastructure of parietal cells were observed by electron microscope. Results Compared with control group(1.97±0.30), pH value in low (3.37± 0.97)and high (5.96±0.26)dose groups were significantly increased(P<0.01), and the activity of H+-K+-ATPase was inhibited obviously at 1 h after administration(3.28±0. 41 vs 1.47±0.27 and 0.92±0.07, P<0.05). Those differences could be found even at 12 h(P<0.01). The ultrastructural changes of parietal cells were consistent with the increase of pH value and decreased activity of H+-K+-ATPase. The significant difference was found in acid depression and excellent time between low and high dose of rabeprazole groups. Conclnsions The uhrastructural changes of parietal cells and the activity of H+-K+-ATPase can accurately reflect the acid secretion in rats. Rabeprazole has powerful and rapid effects in inhibiting acid secretion which correlates with the dosage.

Objective Explore reflux esophagitis age,symptoms,and the relationship between the degree of esophageal damage.Methods Summing up 198 cases of young and middle-aged patients and 104 cases of elderly pa-tients with the symptom score and Endoscopic mucosal injurs classification.Results Under the old group gastroscopy serious esophagitis more than the young group,old age group was 49.97%,25.25%for the young group,but the clini-cal symptoms of heart burn not obvious.Conclusion Reflux esophagitis damaged esophagus increased with age in-crease,but clinical heartburn symptoms do not necessarily obvious,it should attach importance to the brink throat dis-comfort,and other symptoms.