Adult ; Colonic Diseases, Functional ; drug therapy ; metabolism ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Intestinal Mucosa ; metabolism ; Male ; Middle Aged ; Phytotherapy ; beta-Endorphin ; blood ; metabolism

Objective To investigate the role of ca2+/calmodulin-dependent protein kinase II(CaMKII)in chronic inflammatory pain in mice.Methods Forty healthy male ICR mice weighing 20-25 g were randomly divided into 5 groups(n=8 each):group A control;group B chronic inflammation;group C KN92:group D KN93 30 nmol and group E KN93 45 nmo1.Chronic inflammatory pain was produced by injecting complete Freund's adjuvant(CFA) 20 ul into the dorsal surface of left hind paw in group B,C,D and E.In group A normal saline 20 ul was injected instead of CFA.On the 1st and 3rd day after CFA injection group D,E and Creceived intrathecal administration of specific CaMK Ⅱ inhibitor KN93 30 and 45 nmol and KN92 45 nmol(aninactive analog of KN93).in 5 ul respectively.Mechanical and thermal pain threshold to von Frey hair and radiantheat stimulation were determined at 30 min before CFA injection (To,baseline),30 min before(T1) and 30 min after IT.administration (T2) on the 1st day after CFA injection and at 30 min after IT administration(T3) on the 3rd day after CFA injection.The mice were immediately killed by C02 anesthesia after the last determination of pain threshold.The lumbar segment of the spinal cord Was then removed for determination of the expression of p-CaMK Ⅱ a by Western blotting.Results The thermal and mechanical pain threshold Was significantly decreasedat T1-3 in group B,C and D but only at T1 in group E as compared with the baseline values and group A.Thermal and mechanical pain threshold were significantly hisher at T2.3 in group E than in group B.p-CaMKⅡa expression in the spinal cord was significantly higher in group B,C and D than in group A but there was no significant difference in p-CaMKⅡa between group A and E.The p-CaMKII a expression in the spinal cord was significantyly lower in group E than in group B.Conclusion CaMK Ⅱ is involved in the development of chronic inflammatory pain.

The visual angle of active participation reference model was not scientific and its contents were not sys-tematic in the past EBM information service. A new EBM information service model was thus established by compa-ring the finding process of evidence and the transforming process ofinformation-knowledge-intelligence with the need of evidence-based decision making in clinicians as a logic starting point in order to provide the theory of what to do andhow to scientifically do for clinical librarians and clinicians, to effectively direct clinical librarians to perform EBM information service, and to help clinicians to scientifically make their decision.

Objective To construct an effective network machine room (NMR) in hospital. Methods According to Computer Room Design Standard (GB50174-93), the NMR of XiJing hospital was designed and configured in reason with special equipment in such aspects as fitment, power distribution, air conditioning, monitoring, lightning proof, etc. Results The improvement of network machine running condition provided better support to network equipment and ensured the nicety and reliability of the database of XiJing hospital. Conclusion The project attains the anticipated effect. Network equipment running in well environment is the precondition of stabilization of the whole network system in hospital.

After the practical experiences with embedded subject service for research in nursing science in Library , The First Affiliated Hospital of Chongqing Medical University was described , such as constructing and recommending resources for nursing staff , helping them to search and read related resources , providing training service of how to write and submit papers , the models of embedded subject service for research in nursing science were summarized , such as laying equal stress on construction and recommendation of resources , systematic service in the embedding processes , and tackling problems by groups in coordination .

Target restoration space (TRS) is the most precise space required for designing optimal prosthesis. TRS consists of an internal or external tooth space to confirm the esthetics and function of the final restoration. Therefore, assisted with quantitive analysis transfer, TRS quantitative analysis is a significant improvement for minimum tooth preparation. This article presents TRS quantity-related measurement, analysis, transfer, and internal relevance of three TR. classifications. Results reveal the close bond between precision and minimally invasive treatment. This study can be used to improve the comprehension and execution of precise esthetic prosthodontics.
Esthetics ; Esthetics, Dental ; Humans ; Prosthodontics ; methods ; Tooth Preparation

Circulating tumor cells (CTCs), as the seeds of tumor metastasis, manage to escape from immune clearance both in microen-vironment and in peripheral blood. CTCs can also facilitate formation of pre-existing environment, which is the crucial step in metasta-sis. Myeloid-derived suppressor cells (MDSC), as a group of immunosuppressive cells derived from bone marrow cells, may play a key role in this process. In this review, the progress in MDSC and its role in the formation, survival, and immune escape of CTCs were exten-sively discussed to explore a new target for tumor immunotherapy.

Objective To investigate the relationship between the distribution of abdominal adipose tissue and metabolic abnormality in the patients with metabolic syndrome (MS). Methods 108 patients (MS 70 cases, essential hypertension (EH) 22 cases and type Ⅱ diabetes mellitus (T2DM) 16 cases) were enrolled in this study. The visceral adipose (VA) and subcutaneous adipose (SA) were measured with computerized tomography (CT), the ratio of VA/SA was calculated and the correlation between them was analyzed. Results (1) The VA value in MS group was significantly higher compared to both T2DM and EH groups (P

?Objective: To study the craniofacial growth in Chinese girls. Methods: The hand wrist radiographs of 282 chinese girls aged 7 to 14 years old were analysed by CHN scoring method to assess their skeletal age. Furthermore, their lateral cephalometric films were taken and analysed with percentile method. The craniofacial growth percentile curves of the girls were made. Results:The fastest craniofacial growth in the girls took place at the age of 11 to 12. The growth of SN was not significant,but the mandibular length(Co-Gn) increased by 17.3 mm.Conclusion: The data may be reference for the jaw growth prediction

Objective To analyze the dermatology journals indexed by SCI‐E and papers published in recent 5 years ,to pro‐vide advices on periodical selection and contribution .Methods We mainly adopted the bibliometrics methods and word frequency a‐nalysis method to analyze 10 targets in 62 SCI‐E dermatology journals .Results Main publishing nationality were United States , England ,Denmark and Germany ,publishing language was English ,main publishing cycle period was bimonthly journals ,the highest impact factor was 6 .372 .The theme of published content was relatively concentrated ,reviewers′duration was fast and reasonable , 80 .7% submission of the journal was easy .Main type of literature published in recent 5 years is article ,review ,editorial and letter . 58 SCI‐E dermatology journals accept articles from China .Conclusion We suggest that the authors should firstly check the name of dermatology and cross‐disciplinary journals indexed by SCI‐E ,and evaluate the theme of published content ,rate of publishing article contributed from China ,difficulty degree for contribution ,reviewers′duration ,publishing cycle and impact factor when contribution articles .