Target restoration space (TRS) is the most precise space required for designing optimal prosthesis. TRS consists of an internal or external tooth space to confirm the esthetics and function of the final restoration. Therefore, assisted with quantitive analysis transfer, TRS quantitative analysis is a significant improvement for minimum tooth preparation. This article presents TRS quantity-related measurement, analysis, transfer, and internal relevance of three TR. classifications. Results reveal the close bond between precision and minimally invasive treatment. This study can be used to improve the comprehension and execution of precise esthetic prosthodontics.
Esthetics ; Esthetics, Dental ; Humans ; Prosthodontics ; methods ; Tooth Preparation

Adult ; Colonic Diseases, Functional ; drug therapy ; metabolism ; Drugs, Chinese Herbal ; therapeutic use ; Female ; Humans ; Intestinal Mucosa ; metabolism ; Male ; Middle Aged ; Phytotherapy ; beta-Endorphin ; blood ; metabolism

Objective To investigate the role of ca2+/calmodulin-dependent protein kinase II(CaMKII)in chronic inflammatory pain in mice.Methods Forty healthy male ICR mice weighing 20-25 g were randomly divided into 5 groups(n=8 each):group A control;group B chronic inflammation;group C KN92:group D KN93 30 nmol and group E KN93 45 nmo1.Chronic inflammatory pain was produced by injecting complete Freund's adjuvant(CFA) 20 ul into the dorsal surface of left hind paw in group B,C,D and E.In group A normal saline 20 ul was injected instead of CFA.On the 1st and 3rd day after CFA injection group D,E and Creceived intrathecal administration of specific CaMK Ⅱ inhibitor KN93 30 and 45 nmol and KN92 45 nmol(aninactive analog of KN93).in 5 ul respectively.Mechanical and thermal pain threshold to von Frey hair and radiantheat stimulation were determined at 30 min before CFA injection (To,baseline),30 min before(T1) and 30 min after IT.administration (T2) on the 1st day after CFA injection and at 30 min after IT administration(T3) on the 3rd day after CFA injection.The mice were immediately killed by C02 anesthesia after the last determination of pain threshold.The lumbar segment of the spinal cord Was then removed for determination of the expression of p-CaMK Ⅱ a by Western blotting.Results The thermal and mechanical pain threshold Was significantly decreasedat T1-3 in group B,C and D but only at T1 in group E as compared with the baseline values and group A.Thermal and mechanical pain threshold were significantly hisher at T2.3 in group E than in group B.p-CaMKⅡa expression in the spinal cord was significantly higher in group B,C and D than in group A but there was no significant difference in p-CaMKⅡa between group A and E.The p-CaMKII a expression in the spinal cord was significantyly lower in group E than in group B.Conclusion CaMK Ⅱ is involved in the development of chronic inflammatory pain.

After the practical experiences with embedded subject service for research in nursing science in Library , The First Affiliated Hospital of Chongqing Medical University was described , such as constructing and recommending resources for nursing staff , helping them to search and read related resources , providing training service of how to write and submit papers , the models of embedded subject service for research in nursing science were summarized , such as laying equal stress on construction and recommendation of resources , systematic service in the embedding processes , and tackling problems by groups in coordination .

The visual angle of active participation reference model was not scientific and its contents were not sys-tematic in the past EBM information service. A new EBM information service model was thus established by compa-ring the finding process of evidence and the transforming process ofinformation-knowledge-intelligence with the need of evidence-based decision making in clinicians as a logic starting point in order to provide the theory of what to do andhow to scientifically do for clinical librarians and clinicians, to effectively direct clinical librarians to perform EBM information service, and to help clinicians to scientifically make their decision.

Objective To construct an effective network machine room (NMR) in hospital. Methods According to Computer Room Design Standard (GB50174-93), the NMR of XiJing hospital was designed and configured in reason with special equipment in such aspects as fitment, power distribution, air conditioning, monitoring, lightning proof, etc. Results The improvement of network machine running condition provided better support to network equipment and ensured the nicety and reliability of the database of XiJing hospital. Conclusion The project attains the anticipated effect. Network equipment running in well environment is the precondition of stabilization of the whole network system in hospital.

[Obiective] To summarize the research development of the relationship between the occurrence and development of common liver diseases and miRNAs by reading and analysing the literature published in recent 10 years. [Method] By literature retrieval, we consult the literature about miRNA and the clinical research of relevant liver diseases since 2003 and summarize the regulatory mechanism of miRNAs in liver diseases. [Result] miRNAs regulate the expression of target genes at the post-transcriptional level, and they are involved in many important biological processes. In recent years, we can find that miRNAs take part in the regulation of many liver disease-related genes, and the expression level in hepatocellular carcinoma, viral hepatitis, liver fibro-sis, cirrhosis, alcoholic and non-alcoholic fatty liver change in different levels. Part of the regulatory mechanism of miRNAs has been clearly identified, suggesting that miRNAs wil be used as new therapeutic targets for liver diseases. [Conclusion] The regulatory mechanisms of miRNAs in liver diseases make a big difference for the prevention and treatment of liver diseases. These findings provide some novel thoughts about the detection, study and treat-ment about relevant liver diseases. However, many questions are stil vague and unknown, such as the net of its expression and regulation, its biological functions, and the relationship with liver diseases, and al of them are needed to get further attention.

The management of medical equipment is one of the important parts in hospital management,which management quality can directly affect the hospital central task and disciplines construction.How to strengthen the management of medical equipment are studied from the plan of medical equipment,the purchase,book building and application four aspects.

In order to evaluate the post-traumatic changes of serum levels of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNF_?) and their relationship to the occurance of multiple system organ failure (MSOF), 80 adult patients with severe multiple trauma(SMT), injury severity score(ISS) 32?14. served as the tested subjects. of which 50 cases received operations and the other did not. Thirty adult patient, scheduled for elective abdominal surgery, were randomly chosen as trauma control, and 20 healthy blood donors acted as normal control. The venous blood samples were taken on that day of injury, 3, 10 and 20 days post-traumatically, and immediately before dis charge. to measure serum concentrations of IL-6 by immunocytochemistry method and TNF_? by enzymo-immunoassay, respectively. The diagnosis of post-traumatic MSOF was made according to Baue's criteria. As compared with normal control levels, the concentrations of IL-6 and TFN_?, increased significantly in patients with SMT(P0.05). In comparison correspondingly with those of trauma control, the levels of IL-6 and TFN_? were elevated markedly (P

Objective To determine effects of propofol combined with diazepam on GABA-activated chloride currents(IGABA). Methods Whole-cell patch clamp recordings were made from cultured rat dorsal root ganglionic neurons dissociated by collagenase and trypsin, and trituration. 3 ?mol/L GABA was administered by pressure ejection, meanwhile, propofol and diazepam were dissolved in the external solution and were given with the "Y tube" technique. Results Co-application of propofol(0.3, 1.0, 3.0?mol/L) and diazepam (100 nmol/L) potentiated the IGABA ,which was significantly larger than the sum of that potentiated by either drug alone. Diazepam (100 nmol/L ) shifted the concentration-response curve of the propofol-potentiated IGABA to the left in parallel fasion, the EC50 value of propofol was decreased by diazepam from (7.6 ?1.8) ?mol/L to (3.9?1.1 )?mol/L.Conclusions Propofol combined with diazepam synergistically potentiates GABA-gated chloride currents in rat sensory neurons.