Objective To investigate the effect of DSG biologic information infrared liver disease therapy instrument(BILT liver disease therapy instrument)on liver microcirculations in mice.Methods Liver fibrosis was induced in 40 SPF mice which were randomized into 4 groups:without irradiation group,coht light irradiation group,infrared light irradiation group and BILT group(10 in each group).Twenty healthy mice were taken as the control.Liver blood flow of each group was observed by laser-Doppler flow instrument,and blood flow rate of liver microcirculation in each group was observed by intravital microscopy.Pathological examination and serum biochemistry were also performed.Results In fibrosis mice,the liver blood flow in average of BIUF group Was higher than that of without irradiation group(P=0.004),while comparing with without irradiation group there were no significant differences in liver blood flows of the cold light irradiation group and infrared light irradiation group(P=0.713 and 0.465).Red blood cell velocity of microvessels in average of the healthy group(without irradiation)wag higher than that in the without irradiation group offibrosis mice(P=0.001),and it in the BILT group(fibrosis mice)Was also higher than those in other groups of fibrosis mice(P=0.004,0.020 and 0.030).For fibrosis mice,the average AST in BILT group was lower than that in the without irradiation group(P=0.027),and the difference in hydroxyproline(Hyp)levels between the groups was not of statistical significance(P=0.433).Conclusion BILT liver disease therapy instrument can improve the liver microcir-culation,reduce AST level and improve liver pathological state in mouse with fibrosis.

To observe the effects of Salviae miltiorrhizae and its component, salvianolic acid B (SA-B), on the microcirculation of liver in mice with portal hypertension induced by endothelin-1 (ET-1).

Hypoplastic myelodysplastic syndromes (hypo-MDS) is one special type of MDS which is similar to the clinical and laboratory manifestation of aplastic anemia.This it is difficult to differentiate hypoMDS with aplastic anemia.The differential diagnosis includes peripheral blood parameters, bone marrow cell morphology, bone marrow biopsy, hematopoietic progenitor cell culture, cell genetics, molecular biology and cell phenotype analysis, etc.This review will discuss the differential diagnosis between hypo-MDS and aplastic anemia.

Salivary gland acinar cell carcinoma is a rare low grade malignant tumor,which always occurs in the parotid,submandibular and sublingual salivary glands,but extremely rare occurs in the nasal septum.This paper reports a case of the salivary gland acinar cell carcinoma that located in the nasal septum.

Objective To study the impact of diabetes mellitus (DM) and postoperative blood glucose control on the clinicopathological characteristics and prognosis of patients with pancreatic cancer who underwent radical surgery.Methods From January 2010 to January 2015, the clinical and follow-up data of 83 patients with pancreatic cancer who underwent radical surgery at Tianjin Medical University General Hospital were retrospectively studied.Patients were classified into the diabetic group (28 cases) and the non-diabetic group (55 cases) according to the preoperative status of DM.The clinicopathological characteristics, postoperative conditions and prognosis were compared.Results The incidences in the two groups of patients whose postoperative blood glucose levels were poorly controlled were 71.4％ (20/28) and 20.0％ (11/55) in the diabetes group and the non-diabetic groups, respectively.The difference was significant (P ＜0.05).The 3-year survival rate of the diabetic and the non-diabetic groups were 11.3％ and 31.8％ , respectively.The difference was significant (P ＜ 0.05).The 3-year survival rate of patients with poorly-controlled blood glucose levels were 8.8％, and 34.6％, respectively.The difference was significant (P ＜ 0.05).Conclusions The postoperative blood glucose level in pancreatic cancer patients with DM was poorly controlled after radical surgery.The prognosis of pancreatic cancer patients with DM or poorly postoperative blood glucose control was poor after radical surgery.

Objective To examire the effects of hydroxyethyl starch (HES 200/0.5 6%) on lung capillary permeability in endotoxemic rats.Methods Forty-two male Wistar rats weighing 250-300 g were randomly divided into 7 groups with 6 animals in each group: group 1 served as control; group 2 received lipopolysaecharide (LPS) 6mg?kg-1 intraperitoneally (i.p.); in group 3-6 1 min after LPS 6 mg?kg-1 i.p. HES 3.75 ml?kg-1 (group 3), 7.5 ml? kg-1 (group4), 15 ml? kg-1 (group 5) or 30 ml?kg-1 (group 6) was infused i. v. at a rate of 0.2 ml ? min-1 ; group 7 received only HES 30 ml ? kg . The animals were anesthetized with urethane. Right external jugular vein was cannulated for continuous intravenous infusion. Animals were sacrificed at 2 h and 4 h after LPS challenge respectively. Lung capillary permeability, lung wet/dry weight ratio and lung PMN accumulation were measured at 4 h after LPS challenge and nuclear factor Kappa B (NF-?B) activation in the lungs at2 h after LPS challenge.Results HES 3.75 ml?kg-1 and 7.5 ml ? kg-1 significantly reduced LPS-induced increase in lung capillary permeability, lung wet/dry weight ratio and lung PMN accumulation ( P

ObjectiveTo investigate effects of exhaustive swimming on erythrocyte membrane composition. MethodThe components of rat erythrocyte membrane like sialic acid,phospholipid cholesterol ,ratio of cholesterol/phospholipid , -SH and MDA were measured afterexhaustive swimming. ResultThe components of erythrocyte membrane such as sialic acid,phospholipid and-SH decreased significantly while MDA,cholesterol/phospholipid ratio increased after exhaustive swimming,no significant change of cholesterol content was ob-served. ConclusionIt suggested that exhaustive swimming caused significant changes in composition of erythrocyte membrane impairing thedeformability and normal function of erythrocyte.

Different preparations of Hydroxyethyl starch (HES) each have unique molecular weight, degree of substitution and manner of substitution, which are responsible for their intravascular volume expansion and half-life. HES solutions have notable effects on ameliorating hemodynamic and hemorrheological parameters, as well as unique capacity to prevent and reduce capillary leak. Compared with other colloid solutions, HES is more effective, safe and economical. It is an ideal volume expander.

Objective To establish an immortalized rat astrocyte strain(IAST) expressing enkephalin regulated by doxycycline(Dox) and observe its analysesic effect on rat chronic neuropathic pain. Methods Retrovirus infection method was employed to develop an immortalized rat astrocyte strain expression enkephalin regulated by doxycycline.hPPE gene expression level of IAST/Tet-On/hPPE strain was detected by Real time-PCR and radioimmunoassay.Its analgesic potential was investigated by mechanical paw withdrawal thresholds after these cells were implanted into the subarachnoid space of chronic constrictive injury(CCI) rats.The expression of Fos protein in the dorsal horn of spinal cord was determined by immunohistochemistry. Results An immortalized rat astrocyte strain secreting enkephalin under the control of doxycycline was established successfully.After transplantation of IAST/Tet-On/hPPE cell into the subarachnoid space of chronic constrictive injury(CCI) rats, the sensitivity of mechanical allodynia and the expression of Fos protein were significantly decreased(P

Old patients with hand-foot itch were treated by acupuncture combined with the irradiation of TDP. For hand itch, selected acupoints Jianyu (LI 15), Quchi (LI 11), Shousanli (LI 10), Hegu (LI 4), and Zhongzhu (TE 3); for foot itch, selected acupoints Zusanli (ST 36), Sanyinjiao (SP 6), Jiexi (ST 41),Rangu (KI 2), Taichong (LR 3) and Zulinqi (GB 4). OF 33 patients, the symptom were cured in 26 cases and improved in 7 cases after 2-course's treatment.