In 1963, we treated 6 cases of acute radiation sickness (200-8,000 rad) resulted from an accidental uneven 60Co ?-ray irradiation; two of them died of intestinal type within two weeks. Four cases survived and one of them recovered from septicemic shock. Loss of hair, systemic infection, high fever and bleeding occurred in 5 patients. The essential therapeutic measures were strict isolation, preventive treatment with antiinfection drugs, fresh blood transfusion and sometimes infusion of blood formed elements. Among the survivals 2 received homologous bone marrow transplantation.The general conditions of 4 patients followed up for a period of 18 years are apparently good with transparent lens, normal thyroid function and immunological reactions, except one who had low serum IgG level. Three of them showed subnormal adrenocortical activity and impairment of sex gland function. A girl patient (400 rad) gave birth to 2 children one of which has retarded intellectual development. Serial EEG changes occurred only in those received high cranial doses. In all the cases persistence of chromosome aberration in peripheral lymphocytes was observed. With high doses (above 10,000 rad) remote regional effects led to amputation of one leg in one patient and pathological fracture of the femur in another.

A combination of Mexiletine and propranolol was administered in 40'patients suffering from ventricle extrasystole. The results suggest that the effect of the combination is superior to that of mexiletine administered alone

The changes of morphology, ATP and malonaldehyde (MDA) contents, xanthine oxidase (XO) activity as well as the glutathione peroxidase (GSH-px) activity of rabbit aortic endothelial cells under hyperoxia (100% O_2) for 0-72 hours were studied. We found that cellular morphological changes including swelling, shape variation after hyperoxia were time-dependent; after a temporarily increasing (24hr)(P

273 chinese have been studied with high voltage electrophoresis and immumofixation to survey the polymorphism of the third component of human complement in Shaanxi Provice Two C_3 phenotypes were found in this population, they are C_3SS and C_3FS The frequencies of C_3SS and C_3FS are 98.53% and 1.47% respectively. The frequency of C_3S gene is 0.9926 and C_3F gene 0.0073. These results are similar to other studies in China and this group was in Hardy-Weinberg equilibrium. Compared with Negro and Caucasian, the chinese population in Shaanxi Province has a significant difference in C_3 polymorphism.

Accidents, Occupational ; Adult ; Arsenic Poisoning ; Critical Illness ; Fatal Outcome ; Female ; Humans

35%.The patients were premedicated with intramuscular phenobarbital 0.1g and atropine 0.5 mg. In group B and C 8-12 ml?kg-1 of blood was withdrawn from cubital vein in 10-15 min and equal volume of 6% hydroxyethyl was infused at the same speed simultaneously before anesthesia. In group C the blood shed during operation was collected and anticoagulated for reinfusion. Anesthesia was induced with fentanyl 4-6?g?kg-1 , propofol 2 mg?kg-1 and pipecuronium 0.1 mg?kg-1.The patients were mechanically ventilated after tracheal intubation and PETCO2 was maintained at 25-35 mm Hg. Anesthesia was maintained with 1%-3% isoflurane and intermittent iv boluses of fentanyl and pipecuronium. Lactated Ringer's solution was infused at 10-12 ml?kg-1.h-1 during operation in all patients. ECG, NIBP, SpO2, PETCO2 and CVP were monitored throughout anesthesia. Plasma protein, Hct and Hb were measured before and after ANH and after reinfusion of the shed blood. Neuromuscular function was assessed using a train-of-four stimulation (TOF). Onset time, peak effect time (when T1 decreased to 0), duration of action (from the end of pipecuronium injection to recovery of T1 to 25% of the control) of intubation dose and maintenance dose and recovery index (recovery of T1 from 25 % - 75%) were recorded.Results Demographic data including sex, age, body weight and height were not significantly different among the three groups. The vital signs were stable in the three groups. Plasma total protein and albumin concentrations, Hb and Hct decreased significantly after ANH in group B and C and were significantly lower than those in group A. After autologous transfusion there was no significant difference in plasma protein concentration and Hb between group A and B. Hb and Hct were significantly higher in group C than those in group A and B (P

Objective To investigate the parents' attitude toward the handicapped children learning in regular class.MethodsThe Questionnaire of the Parents' Attitude Toward Learning in Regular Class was used to measure the attitude of 240 parents of handicapped children and 480 of normal children. ResultsThe attitude of parents of handicapped children was much more positive than that of parents of normal children. The attitude of parents of deaf children is much more positive than that of parents of mental retarded (MR) children. The attitude of parents of normal children who were studying with the deaf children was much more positive than that of parents of normal children who were studying with the MR children. There was no significant difference among parents of different education levels, occupation and sex. ConclusionHandicapped children learning in regular class need more attention from parents.

ObjectiveTo workout a scale of parents' attitude towards handicapped children learning in regular class.MethodsQuestionnaire on the parents' attitude toward learning in regular class was designed and administered to 240 parents of handicapped children and 480 parents of normal children.ResultsThe questionnaire was consisted of 34 valid items and proved to be a reliable and valid instrument.ConclusionThis questionnaire is an innovation on testing attribute to some limitation, but the normal formulation has to be depended on future study.

Administrative Personnel ; China ; Health Knowledge, Attitudes, Practice ; Humans ; Industry ; manpower ; Occupational Health

BACKGROUND: Chinese medicine xinmailong (XML) injection is a kind of new nucleoside compound which comes from American giant cockroach of insects. A lot of studies show that XML has obvious effect on cardiovascular activity which can treat acute or chronic congestive heart failure and shock and improve microcirculation.OBJECTIVE: To observe the effect of XML on anti-aging of mice.DESIGN: Controlled observational study.SETTING: Department of Physiology and Pathology, Basic Medical College of Dali College.MATERIALS: The experiment was carried out at the Functional Laboratory of Basic Medical College between July 2002 and September 2004. A total of 40 ICR mice of both sexes were provided by Kunming Medical College,Yunnan Naturally Occurring Drugs Key Laboratory. XML injection was provided by Yunnan Tengchong Pharmacy Factory [batch number: 94 (ZL) 03].METHODS: A total of 40 ICR mice were randomly divided into 4 groups:young control group, aging control group, XML group at high dosage and XML group at low dosage with 10 in each group. All mice were fed routinely with standard feed. Mice in young control group aged 3 months and weighed (20±2) g; meanwhile, mice in other groups aged 20 months and weighed (40±3) g. From the 20th month, mice in XML groups were intraperitoneally injected with 6 mg/kg and 8 mg/kg, respectively, for 30 days with once every day. Mice in young and aging control groups were intraperitoneally injected with the same volume of saline. On the 31st day,heads of mice were cut off to obtain blood which was maintained at hepalean anti-coagulated tube. Brains and livers were obtained rapidly for homogenate with 10% saline. Activities of catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px) in serum, content of malondialdehyde (MDA) in brain tissue and content of lipofuscin in cerebral and hepatic tissue were measured according to introduction of kits.MAIN OUTCOME MEASURES: ① Activities of CAT, SOD and GSHPx in serum; ② content of MDA in brain tissue and contents of lipofuscin in cerebral and hepatic tissues.RFSULTS: A total of 40 animals were involved in the final analysis without any loss. ① Activities of CAT, SOD and GSH-Px in serum of mice were lower in aging control group than those in young control group; however,activities of CAT, SOD and GSH-Px in serum of mice were increased in the two XML dosage groups, and there was significant difference from those in aging control group (P ＜ 0.05 or P ＜ 0.01). ② Content of MDA in brain tissue and contents of lipofuscin in cerebral and hepatic tissues of mice in aging control group were higher than those of mice in young control group, but those in the two dosage groups were decreased, which was significant difference from those of mice in aging control group (P ＜ 0.01). However, there was no significant difference between the two dosage groups.CONCLUSION: XML has an effect on anti-aging through improving metabolism of free radicals.