Spasticity is a common complication of stroke.It may cause the function and ability of patients to be restricted significantly and affect the quality of life of both patients and their caregivers.The estimated prevalence of poststroke spasticity (PSS) is 19％ to 42.6％.PSS can be usually assessed by the Modified Ashworth Scale,Modified Tardieu Scale,and electromyography.Therapeutic methods of PSS include physical therapy and drug treatment.The treatment options should be individualized.

Chuan Ya Wai Bian (External Therapies of Folk Medicine), compiled by ZHAO Xue-min, a medical expert in Qing Dynasty, is abundant in folk external therapies including acupuncture, moxibustion, acupoint sticking therapies, which all have unique features. Folk acupuncture-moxibustion is an important part of acupuncture- moxibustion therapy, playing a role that can't be replaced by conventional acupuncture-moxibustion. It's worth exploring and needs constant improvements to adapt to the requirement of modern medicine, which is also significant for boosting the development of acupuncture-moxibustion therapy.

The value of dobutamine 99m橳c-MIBI SPECT (DBA-SPECT) for detecting coronary artery disease was assessed in 56 patients with chest pain. Exercise ECG, DBA-ECG and DBA-SPECT were obtained. The hemodynamic changes in DBA infusion are similar to that in exercise test. In 21 patients who had coronary angiogram,the sensitivity,specificity and accuracy were 87. 5% ,76. 9% ,81. 7% ,respectively in DBA-SPECT;75. 0%, 92. 3%, 85. 0%, respectively in DBA-ECG,and 87. 5%,46. 2% ,61.9% ,respectively in exercise ECG test. The results showed that DBA-SPECT is a feasible safe and non-invasive method for detecting coronary artery disease.

[Objective]To investigate the expression of protein destrin in cytoskeleton protein in traumatic arterial aneurysm(TAA) vessel wall tissue and its relationship with clinical representations and pathological characteristics.[Method]Western-blot analysis and RT-PCR were used to detect the quantitative expression of destrin protein in 13 patients with TAA and in the femoral arterial tissues of 8 normal subjects.The difference of protein expression was compared,and the results with clinical data were analyzed statistically.The correlation of unbalanced expression of destrin protein with the clinical presentations was studied.[Result] The expression of destrin in TAA tissue was lower than that in the femoral artery of normal subjects(P

Objective: To investigate the ictal epileptic activation using simultaneous electroencephalogram functional MRI(EEG-fMRI),and to study the neural mechanism and the roles of the cerebral cortex and subcortical structures in the generation and propagation of the epileptic activity.Methods: A patient with partial epilepsy was retrospectively found to have slight seizures during the simultaneous EEG-fMRI examination.Two sessions of the ictal functional MRI data were processed and analyzed using the general-linear model.Results: Consistent activation patterns were obtained from the two sessions of data.The positive activation was found over the bilateral parietal lobes,insula cortex,bilateral striatum,thalamus and some nuclei of the brain stem,as well as over the vermis and right cerebellar hemisphere.The maximum intensity point was in the left parietal lobe.Conclusion: The seizure activation is originated from the cerebral cortex,and then propagates through the reciprocal circuits made up of the cortex and the subcortical structures.The cerebral cortex and the brain stem reticular formation are the main structures that propagate the seizure to contralateral hemisphere.The subcortical structures play important roles in the seizure propagation and seizure manifestation.

Adolescent ; Adult ; Deafness ; diagnosis ; etiology ; psychology ; Diagnostic Errors ; Female ; Hearing Loss, Sudden ; diagnosis ; Humans ; Male

The expression of microRNA (miRNA) is closely related to radio-chemosensitivity in glioma stem cells (GSCs).Moreover,the growth of glioma stem cells could be inhibited comprehensively by increasing radio-chemosensitivity and apoptosis,simultaneously with the regulation of a single miRNA,which has been confirmed by some researches.Thereby microRNA is prospective for the adoption as a specific agent in targeted therapy of glioma,so as to increase the radio-chemosensitivity in glioma stem cells.

Objective To evaluate the effects of betulinic acid preconditioning on oxidative stress response during cerebral ischemia-reperfusion (I/R) in mice.Methods Seventy-two male Kunming mice,aged 3 months,weighing 25-35 g,were randomly divided into 3 groups (n =24 each) using a random number table:sham operation group (group S),I/R group,and betulinic acid preconditioning group (group BP).Cerebral I/R was induced by middle cerebral artery occlusion in mice anesthetized with 10％ chloral hydrate 40 ml/kg.In group BP,betulinic acid 50 mg/kg was administered by intragastric gavage everyday for 7 days before ischemia,while the equal volume of solvent dimethyl sulfoxide was given in S and I/R groups.At 22 h of reperfusion,neurological function was assessed and scored.The mice were then sacrificed and brains were removed for determination of infarct size,expression of NADPH oxidase (Nox1,Nox2 and Nox4) and p22phox mRNA,activity of ROS and apoptosis rate in the infarcted zone.Results Compared with S group,neurological score,cerebral infarct size,activity of ROS and apoptosis rate in the infarcted zone were significantly increased,and the expression of Nox1,Nox2,Nox4 and p22phox mRNA was up-regulated in group I/R.Compared with group I/R,neurological score,cerebral infarct size,activity of ROS and apoptosis rate in the infarcted zone were significantly decreased,and the expression of Nox1,Nox2,Nox4 and p22phox mRNA was down-regulated in group BP.Conclusion Betulinic acid preconditioning mitigates cerebral I/R injury through inhibiting oxidative stress response in mice.

Objective To investigate the distribution and drug resistance of pathogens isolated from blood culture samples from January 2012 to October 2013 to provide the basis for clinical lection of antibacterial drugs.Methods The blood samples were col-lected from the patients with suspected blood infection and cultured by the BD BACTEC 9120 automatic blood culture instrument. The samples with positive results were performed the bacterial identification and the drug sensitivity test by using the VITEK-2 COMPACT automatic bacterial identification instrument.Results A total of 969 strains of pathogens were isolated from blood cul-ture samples,including 540 strains(55.7%)of Gram-positive bacteria,413 strains(42.6%)of Gram-negative bacteria and 16 strains (1.7%)of fungi.The top 3 isolated pathogenic bacteria were Staphylococcus epidermidis,Escherichia coli and Staphylococcus au-reus.Staphylococcus epidermidis and Staphylococcus aureus were highly resistant to penicillin,sensitive to vancomycin and linezol-id;Escherichia coli and Klebsiella pneumoniae were highly sensitive to imipenem and Piperacillin/tazobactam.Conclusion It is nec-essary to understand the blood culture results timely so as to provide the basis for clinical antibacterial therapy and the improvement of the cure rate.

Objective To make a comparative assessment on both the therapeutic effects and side effects between percutaenous lauromacrogol injection therapy(PLIT) and percutaenous ethanol injection therapy(PEIT) for simple hepatic or renal cyst.Methods In group A,55 patients with simple hepatic or renal cysts underwent ultrasound-guided aspiration and successive PLIT.The intra-operative side effects were investigated and the therapeutic effects assessment by using ultrasonography was conducted 3 months after the treatment.In group B,60 patients with simple hepatic or renal cysts had received ultrasound-guided aspiration and PEIT sometime before.The intra-operative side effects and therapeutic effects on the thirdmonth ultrasonography were independently reviewed according to their case records.Results In group A,3 patients(5.5 ％) expressed slight discomfort but not pain while receiving lauromacrogol injection.Follow-up ultrasound examination at the end of third month demonstrated the cysts in 43 patients completely regressed,while cysts in rest 12 patients shrank over 50 ％ in size,showing the overall response rate(ORR) and completely cure rate(CCR) were 100％ (55/55) and 78.2％ (43/55) for PLIT respectively.In group B,12 patients(20％) suffered from slight to moderate irritating pain or drunk performance.The third-month ultrasound examination disclosed that cysts in 47 patients completely vanished,and cysts in the other 13patients shrank more than a half,indicating the ORR and CCR were 100％ (60/60) and 78.3 ％ (47/60) for PEIT respectively.Conclusions Although their therapeutic efficacy are perfectly similar,PLIT is much more superior to PEIT in term of less and minor side effects.