OBJECTIVETo study the protection of seed oil of Hippophae rhamnoides on ischemic cerebral infarction in rats and the mechanism of the action.

METHODFocal cerebral ischemia model was made by middle cerebral artery occlusion(MCAO) in rats. Behavior obstacles of rats were observed. Cerebral infarction volume was determined by Megnetic Resonance Imaging(MRI).

RESULTSeed oil of Hippophae rhamnides 0.7 and 0.35 g.kg-1 could markedly reduce infarction volume after occlusion of middle cerebral artery in rats and also could ameliorate the behavior obstacles of rats.

CONCLUSIONThese results suggested that seed oil of Hippophae rhamnoides had distinct protection to ischemic cerebral infarction in rats.

Animals ; Behavior, Animal ; drug effects ; Drugs, Chinese Herbal ; isolation & purification ; pharmacology ; Hippophae ; chemistry ; Infarction, Middle Cerebral Artery ; pathology ; physiopathology ; Male ; Neuroprotective Agents ; pharmacology ; Plant Oils ; isolation & purification ; pharmacology ; Plants, Medicinal ; chemistry ; Rats ; Rats, Wistar ; Seeds ; chemistry