Chronic Disease ; Heart Failure ; metabolism ; Humans ; Phosphorylation ; Ryanodine Receptor Calcium Release Channel ; metabolism

OBJECTIVETo investigate the change of the mortality of AMI and influence factors within 20 years.

METHODSClinic data of 134 AMI patients from 1980 to 1983, 354 AMI patients from 1990 to 1993 and 817 AMI patients from 2000 to 2003 were comparably analyzed.

RESULTSIn hospital mortality of AMI was 22.4% from 1980 to 1983, 14.4% from 1990 to 1993 and 9.2% from 2000 to 2003, respectively (P < 0.01). The decrease of in-hospital mortality in male was more significant than in female (P < 0.01). The corresponding factors for decrease of mortality were younger than 60 years old, first onset of AMI, successful rescue of cardiac arrest and reperfusion management of infarction relative artery. The disadvantage factor was female.

CONCLUSIONSImprovement of medical and reperfusion management of AMI conduced in significant decreases of hospital mortality.

Adrenergic beta-Antagonists ; therapeutic use ; Aged ; Angiotensin II Type 1 Receptor Blockers ; therapeutic use ; Angiotensin-Converting Enzyme Inhibitors ; therapeutic use ; Cause of Death ; Female ; Hospital Mortality ; Humans ; Inpatients ; Logistic Models ; Male ; Middle Aged ; Myocardial Infarction ; diagnosis ; mortality ; therapy ; Myocardial Reperfusion ; Prognosis ; Retrospective Studies ; Risk Factors