1.Manufacture and experimental study of the categorizing pedestal of multi-function apparatus in the supply room
Ti HE ; Shunjiao DENG ; Li CHEN ; Dengdian FENG ; Yuanxiang XIONG ; Donglan LIAN ; Yuyu LIU ; Ying HU
Chinese Journal of Practical Nursing 2008;24(22):1-2
Objective To control the nosocomial infection and avoid the second pollution of thereclaimed medical apparatus to the washing area of supply room. Methods Count, classification and place of the reclaimed medical apparatus went along at the same self-designed categorizing pedestal of the muhi-function apparatus.No absorbing cloth was needed on the table-board, the dirty water flew into the outfall of the sewer directly and automatically, the discreteness could be unpicked, washed and lis-terized after work. Results It avoided the collision of the apparatuses, shortened the time of counting effectively and reduced the chance of pollution.It also avoided the waste of the manpower, the material resources, the time and the second environmental pollution. The effects of the two table-boards after disinfection had statistical difference (P<0.01). Conclusions The categorizing pedestal of the mul-ti-function apparatus makes the reclaim and handling of the polluted apparatus more standard and to re-move the pollution more thoroughly.
2.Factors Influencing and Adverse Reactions of Voriconazole Clearance in Patients with Hematological Diseases.
He-Gui HUANG ; Hai-Lin WANG ; Yi-Kai LIN ; Yan-Dong YI ; Min LIU ; Jun-Li DONG ; Jian-Min LIU ; Fan CHEN ; Ti-Ying DENG ; Song HU
Journal of Experimental Hematology 2023;31(2):562-567
OBJECTIVE:
To monitor the changes of voriconazole minimum concentration(Cmin) in patients with hematological diseases, and evaluate the factors influencing and adverse reactions of voriconazole clearance in patients with hematological diseases, so as to provide a theoretical basis for reasonable clinical use of voriconazole.
METHODS:
136 patients with hematological diseases who used voriconazole in Wuhan NO.1 Hospital from May 2018 to December 2019 were selected. The correlation between C-reactive protein, albumin, creatinine and voriconazole Cmin were analyzed, and the changes of voriconazole Cmin after glucocorticoid treatment was also detected. In addition, stratified analysis was used to explore the adverse events of voriconazole.
RESULTS:
Among 136 patients, 77 were male (56.62%) and 59 were female (43.38%). There were positive correlations between voriconazole Cmin and C-reactive protein and creatinine levels (r=0.277, r=0.208), while voriconazole Cmin was negatively correlated with albumin level (r=-2.673). Voriconazole Cmin in patients treated with glucocorticoid was decreased significantly (P<0.05). In addition, sratified analysis of voriconazole Cmin showed that compared with voriconazole Cmin 1.0-5.0 mg/L group, the incidence of adverse reactions of visual impairment in voriconazole Cmin> 5.0 mg/L group was increased (χ2=4.318, P=0.038).
CONCLUSION
The levels of C-reactive protein, albumin and creatinine are closely related to the voriconazole Cmin, which indicate that inflammation and hyponutrition may prevent the clearance of voriconazole in patients with hematological diseases. It is necessary to monitor the voriconazole Cmin of patients with hematological diseases, and adjust the dosage in time to reduce adverse reactions.
Humans
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Male
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Female
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Voriconazole/therapeutic use*
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Antifungal Agents/therapeutic use*
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C-Reactive Protein
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Creatinine
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Glucocorticoids
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Retrospective Studies
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Drug Monitoring
;
Hematologic Diseases