At the Hospital N0103, the characteristics of basedow symptoms were studied in 125 patients with basedow in combining with Hashimoto disease in comparing with 88 patients of simple basedow. Results showed no obvious difference between simple basedow patients and basedow associated with Hashimoto in terms of age of developing disease, of peripheral white blood cells, of basal metabolism, electro heart rate, T3, T4, FT4 level and Thyrotropin. 100% of patients who were diagnosed pathoanatomically as basedow in combining with Hashimoto, were diagnosed clinically as simple basedow. 98.8% of patients of basedow in combining with Hashimoto who underwent a biopsy of cell aspiration had got confirmed diagnosis
Thyroiditis, Autoimmune ; Graves Disease ; Hashimoto Disease

No abstract available.
Thyroiditis, Autoimmune*

BACKGROUND: Postpartum thyroiditis(PPT) is one of syndromes of thyroid dysfunction that occurs in the first year after parturition. Reported incidence of PPT is 3.9-8.2% of postpartum women in several studies from different countries. The fact that 52-100% of patients with PPT have thyroid autoantibodies, and that lymphocytic infiltration of thyroid gland is the characteristic pathological feature of PPT suggest that PPT is an autoimmune disease. High iodine intake in short term period is known to aggrevate the experimental autoimmune thyroiditis. This study was performed to investigate the incidence and clinical features of PPT in Korean postpartum women who usually ingest excessive amount of idine in immediate postpartum period and to investigate the predictive value of thyroid autoantibodies in the development of PPT in them. METHOD: Between March 1996 and February 1997, 99 women without previous history of any thyroid disease who delivered babies at Boramae hospital were enrolled. Thyroid function parameters(T3, T4, free T4, TSH), thyroid autoantibodies(anti-microsomal antibody, anti-thyroglobulin antibody) and urinary iodine excretion were measured prospectively before and 1, 3 months after delivery. Dietary iodine intake during postpartum period was evaluated by questionnaire, and clinical parameters were followed up. RESULTS: During 3 months of observation, PPT developed in 8.1%(8/99) of postpartum women. Five cases had typical course having thyrotoxic phase and the other 3 cases had hypothyroid phase without toxic phase. However, only one of those required thyroid hormone replacement therapy in the latter group. There were no differences in age, baseline thyroid function parameters, parity, percent cases with family history of thyroid disease between those developed PPT (n=8) and those did not develop PPT(n=91). Duration of high iodine intake(3.8 +- 0.5 wk. vs. 3.7 +- 0.8 wk., p>0.05), total ingested amount of high iodine diet(77 +- 28 vs. 79 +- 24 bowels of miyokguk, p)0.05), and the urinary iodine excretion(1.9 +- 1.4 mg/g creatinine vs. 3.7 +- 3.7mg/g creatinine, p0.05) at 1 month postpartum were not different between two groups. Of 99 total subjects, anti-microsomal antibody(AMA) was present in 13.1%(13/99) before delivery in their sera. Positive predictive value of the presence of AMA before delivery in predicting the development of PPT was 30.8%. CONCLUSION: The fact that incidence of PPT in normal Korean postpartum women who usually have high iodine intake in immediate postpartum period is not higher than those of other countries, and that there was no difference in the amount of iodine intake between those developed PPT and those did not suggest that high iodine intake in immediate postpartum period do not influence on the incidence of PPT. The presence of AMA before delivery had low specificity in prediction of development of PPT, so the measurement of AMA seems not to be a useful screening test.
Autoantibodies ; Autoimmune Diseases ; Creatinine ; Female ; Hormone Replacement Therapy ; Humans ; Incidence* ; Iodine* ; Mass Screening ; Parity ; Parturition ; Postpartum Period* ; Postpartum Thyroiditis* ; Prospective Studies ; Surveys and Questionnaires ; Sensitivity and Specificity ; Thyroid Diseases ; Thyroid Gland ; Thyroiditis, Autoimmune

No abstract available.
Thyroiditis, Autoimmune ; Turner Syndrome

No Abstract available.
Abscess* ; Thyroid Gland* ; Thyroiditis, Autoimmune ; Thyroiditis, Suppurative

Henoch-Schonlein purpura (HSP) is a small-vessel vasculitis involving skin, gut, and kidney associated with arthralgia, arthritis and characterized by immunoglobulin A (IgA)-dominant immune deposits in target organs. This vasculitis is common in children and rarely reported to be associated with other autoimmune disease such as rheumatoid arthritis, autoimmune thyroiditis. We report the case of 72 year-old man who developed adult-onset HSP and also had rheumatoid arthritis and chronic lymphocytic thyroiditis. This is the first report in South Korea.
Aged ; Arthralgia ; Arthritis* ; Arthritis, Rheumatoid ; Autoimmune Diseases ; Child ; Hashimoto Disease* ; Humans ; Immunoglobulin A ; Kidney ; Korea ; Purpura, Schoenlein-Henoch* ; Skin ; Thyroiditis ; Thyroiditis, Autoimmune ; Vasculitis

No abstract available.
Biopsy, Fine-Needle* ; Thyroiditis, Autoimmune*

BACKGROUND AND OBJECTIVES: The relationship between Hashimoto thyroiditis (HT) and papillary thyroid cancer (PTC) is still controversial. Some studies suggested that molecular basis of the association between HT and PTC. BRAF(V600E) mutation is the most common genetic alteration founded in PTC. This study was to determine a role of BRAF(V600E) mutation in PTC with concurrent HT and their association with other clinicopathological factors. MATERIALS AND METHODS: We enrolled 452 patients who underwent thyroid surgery between 2009 and 2012 for classical PTC. The status of BRAF(V600E) mutation was evaluated by direct sequencing. HT was defined as presence of lymphocytic thyroiditis in pathology or positive serum anti-thyroid peroxidase antibody. RESULTS: Total 139 patients (30%) with PTC had coexistence HT. HT was significantly associated female (p=0.006), and younger age (p=0.045). BRAF(V600E) mutation was confirmed in 264 patients (58%). The frequency of BRAF(V600E) mutation was significantly lower in PTC with coexistence HT (48.2%) compared by PTC without HT (62.9%, p=0.004). However, there was no significant difference in clinicopathological feature of PTC according to the presence of HT in patients with BRAF(V600E) mutated PTC. BRAF(V600E) mutation was less frequent in PTC with coexistence HT. CONCLUSION: These findings suggested that HT and BRAF(V600E) mutation might be independent factors in development and progression of PTC.
Female ; Hashimoto Disease* ; Humans ; Pathology ; Peroxidase ; Thyroid Gland ; Thyroid Neoplasms ; Thyroiditis, Autoimmune

Kikuchi-Fujimoto disease (KFD) is a benign and self-limited disease characterized by fever and lymphadenopathy. The etiology of KFD is unknown, but an autoimmune cause has been suggested. Hashimoto thyroiditis is the most common autoimmune thyroid disorder in children and is known to be associated with other autoimmune diseases. Only a few cases of Hashimoto thyroiditis associated with KFD have been documented. We report a case of a 16-year-old girl who was first diagnosed with KFD and developed Hashimoto thyroiditis 2 years and 6 months later during her follow-up period. Physicians of patients with KFD should consider the possibility of autoimmune diseases like Hashimoto’s thyroiditis.
Adolescent ; Autoimmune Diseases ; Child ; Female ; Fever ; Follow-Up Studies ; Hashimoto Disease* ; Histiocytic Necrotizing Lymphadenitis* ; Humans ; Lymphatic Diseases ; Thyroid Gland ; Thyroiditis

No abstract available.
Lupus Erythematosus, Systemic* ; Sarcoidosis* ; Thyroiditis, Autoimmune