BACKGROUND: We evaluated the effect of two drugs with anti-inflammatory action, dexamethasone and ketorolac, on reduction of postoperative sore throat (POST) after general anesthesia with endotracheal intubation in patients undergoing thyroidectomy. METHODS: One hundred and ninety-two female patients scheduled to undergo general anesthesia with endotracheal intubation for thyroidectomy were enrolled in this prospective study. Participants were randomly allocated to receive intravenous medication; placebo (Group C, n = 45), ketorolac 30 mg immediately before intubation (Group Kpre, n = 47), ketorolac 30 mg at the end of surgery (Group Kpost, n = 45) and dexamethasone 10 mg (Group D, n = 43). The incidence and severity of POST and hoarseness were evaluated at 1, 6 and 24 hours after surgery. RESULTS: Incidences and severities of POST at rest and during swallowing in first 6 hours after extubation were comparable among 4 groups. At 24 hours postextubation, the incidence (P = 0.002, 95% CI of proportion differences; 0.05–0.39) and severity (P = 0.008) of POST during swallowing were significantly lower in group D than in group C. Kpre and Kpost groups did not show a greater reduction in POST than group C, despite lower rescue analgesic requirement at 1 hour after extubation in group Kpre (P = 0.006; 95% CI of proportion differences; 0.07–0.38). No intergroup differences were observed in incidences of hoarseness or adverse events. CONCLUSIONS: Intravenous administration of dexamethasone 10 mg, but not ketorolac, before induction of anesthesia reduces the incidence and severity of POST during swallowing at 24 hours after thyroidectomy.
Administration, Intravenous ; Anesthesia ; Anesthesia, General ; Deglutition ; Dexamethasone* ; Female ; Hoarseness ; Humans ; Incidence* ; Intubation ; Intubation, Intratracheal ; Ketorolac* ; Pharyngitis* ; Prospective Studies* ; Thyroidectomy*

BACKGROUND: Diffusion of nitrous oxide into the cuff of the endotracheal tube (ETT) results in an increase in cuff pressure. This method was used to test whether tracheal morbidity is related to fill the cuff of the endotracheal tube with alkalinized lidocaine instead of air or lidocaine only. METHODS: Adult patients scheduled for total thyroidectomy surgery were randomly enrolled (n = 30 for each group).The ETT cuff was filled with air 6 ml (Group C), with 2% lidocaine 6 ml (Group L), or with alkalinized lidocaine (4 ml or 2 ml of 2% lidocaine) using 2 ml (Group A) or 4 ml (Group B) of 8.4% NaHCO3.After tracheal extubation, sore throat was evaluated by visual analog scale as the main end-point of the study. RESULTS: Compared with group air or lidocaine only, the alkalinized-lidocaine groups had a significant reduction in sore throat during the 24-h postoperative period (P < 0.001).The difference was not significant between the two alkalinized lidocaine groups. Cough before tracheal extubation, nausea, postoperative vomiting, dysphonia, and hoarseness after extubation were decreased in the alkalinized-lidocaine groups compared with Group C and L, and a better tolerance was recorded with alkalinized-lidocaine groups compared with Group C and L. CONCLUSIONS: We concluded that use of intracuff alkalinized lidocaine is an effective adjunct to endotracheal intubation instead of air or lidocaine only during nitrous oxide anesthesia, however there were no differences between two alkalinizations.
Adult ; Airway Extubation ; Anesthesia ; Cough ; Diffusion ; Dysphonia ; Hoarseness ; Humans ; Intubation, Intratracheal ; Lidocaine ; Nitrous Oxide ; Pharyngitis ; Postoperative Nausea and Vomiting ; Postoperative Period ; Sodium Bicarbonate ; Thyroidectomy ; Vomiting

Introduction: During a thyroidectomy, the neck is hyperextended. This position may inverse the tracheal axis to the endotracheal tube (ET), can cause damage to the vocal cords and tracheal wall. We propose a simple turn of the ET corresponding with the laryngo-tracheal axis to reduce of post-operative sore throat (PST) and hoarseness (H) in thyroidectomy patients. Methods: 122 patients undergoing general anesthesia were prospectively randomized divided into 4 groups. Gp1 (n=31): normal ET tube placement. Gp2 (n=30): normal ET tube rotated 180o following insertion. Gp3 (n=30): armoured tube. Gp4 (control, n=31): Normal ET tube in operations other than thyroidectomy, that require hyperextension. Cuff pressure (CP) and inspiratory peak pressure (IPP) were monitored during anesthesia. PST and H were evaluated by a VAS (0-10mm). Results: The 4 groups were similar in age, gender and intubation duration. IPP remained stable in all 4 groups. However, CP increased significantly in Gp1 and Gp4 after hyperextension. GP1 had the most PST and H (p<0.05). Tube rotation achieved the same results as the Armoured tube. Discussion: Rotating ET tube 180o reduced PST and H as much as intubation with a armoured tube. This rotation did not interfere with ventilation during anesthesia.
Thyroidectomy, Hoarseness, Pharyngitis, Intubation, Intratracheal