No abstract available.
Diagnosis ; Thyroid Gland ; Thyroid Neoplasms

249 patients (28 males, 221 females) undergone surgical treatment for thyroid cancer at the Hospital of Endocrinology from the 7th January 2002 to the 30th June 2004. Thyroid cancer was more likely in male than in female. The clinical signs were not usually acute and likely passed by in the early stage of this disease. The fine needle aspiration was the paraclinical method which had the most value in order to diagnose thyroid cancer before surgery. Total thyroidectomy or total thyroidectomy associated with cervical node dissection were the most common procedure in durgical treatment for thyroid cancer. Papillary carcinoma and follicular carcinoma in 94%. Complications and sequel after operation for parathyroid and laryngeal nerve were low in 249 patients undergone surgical treatmnent
Thyroid Neoplasms ; diagnosis ; Therapeutics ;

Study on 32 differentiated thyroid carcinoma patients treated at Hospital K from October 2002 to May 2003. Results: thyroid carcinoma often occurred in young people, group of 31-50 years old accounted for more than 50% of patients, more common in female than male. The initial common symptoms are thyroidal tumor and cervical nodes. The rate of hospital admission after onsets 1-2 years was 62.5%. The rate of cervical nodes can be clinically discovered was 62%. Carotid nodes were common and nodal metastases commonly occurred in papillary carcinoma. Histological diagnosis showed that papillary carcinoma accounted for 81.25% and follicular carcinoma was 18.75%. Surgical treatments were commonly total thyrodectomy in combination with radiotherapy.
Thyroid Neoplasms ; Diagnosis ; Therapeutics

From Jan. 2001 to Dec. 2002,at the Hospital K in Hanoi,112 cases of thyroid carcinoma (99 females and 13 males, among them 79,45% aged 21-60 years old) were studied. Among all 5 pathohistological types of thyroid carcinoma, papillome-carcinoma occupied 83,14% in both two genders, cystic-carcinoma 14,28% only in female. Undifferenciated carcinoma occupied 2,56% ;rather characterized for each type. Differenciated carcinoma was more common, with specific characters easy to identify. Undifferenciated carcinoma had got polymorphism characteristic cells, large necrosis, polynucleus
Thyroid Neoplasms ; Carcinoma ; Diagnosis ; Epidemiology

BACKGROUND: The overexpression of cyclin D1 and galectin-3 and the loss of p27 in thyroid cancers have recently been reported by many studies. The S-phase kinase associated protein 2 (skp2) plays an important role in the degradation of p27. We compared the correlation of the expressions of galectin-3, p27, cyclin D1 and skp2 in thyroid lesions. METHODS: Sixty five cases were included in this study and immunohistochemical staining for galectin-3, skp2, p27 and cyclin D1 was performed. RESULTS: The expression of galectin-3 increased in the order of nodular hyperplasia, follicular adenoma, follicular carcinoma and papillary carcinoma (p<0.01). The expression rate of skp2 was 0% for nodular hyperplasia, 16.7% for follicular adenoma, 33.3% for follicular carcinoma and 16.7% for papillary carcinoma. The loss of the expression of p27 was more frequently detected in papillary carcinoma as compared with nodular hyperplasia (p<0.01). The increased expression of cyclin D1 was noted in follicular adenoma and carcinoma as compared with nodular hyperplasia (p=0.043). The expression of galectin-3 was related with the loss of a p27 expression (p<0.01), and the expression of skp2 was related with the expression of the cyclin D1 (p=0.022). CONCLUSIONS: Galectin-3 appears to be the most useful marker for making the diagnosis of thyroid lesions. The loss of a p27 expression can help differentiate nodular hyperplasia and papillary carcinoma, and the determining the expression of cyclin D1 may be helpful for the differential diagnosis of nodular hyperplasia and follicular neoplasm.
Diagnosis, Differential ; Adenoma ; Thyroid Neoplasms

Humans ; Thyroid Neoplasms ; diagnosis ; surgery

PURPOSE: To evaluate the diagnostic accuracy of routine calcitonin measurement in patients with nodular thyroid disease. METHODS: Consecutive patients with nodular thyroid disease (n = 640) were studied. Serum calcitonin levels were measured under basal conditions, and when basal values were between 10–100 pg/mL, testing was repeated after pentagastrin (PG) stimulation. Patients with previously diagnosed or familial medullary thyroid cancer (MTC) were excluded. Patients were operated on when basal or stimulated calcitonin >100 pg/mL or when other surgical indications were present. RESULTS: Four cases of MTC were identified. MTC was diagnosed in 75% of patients with basal calcitonin >100 pg/mL. One out of 11 patients with basal calcitonin between 10–100 pg/mL was diagnosed with MTC. PG stimulation resulted in elevation in 4 cases, where 1 case was diagnosed with MTC. Positive predictive value for basal calcitonin levels in the preoperative diagnosis of MTC was 5% for values between 10–100 pg/mL and 100% for values >100 pg/mL. Possible reasons for false positivity were papillary thyroid cancer in 17%, renal insufficiency in 8.3%, Hashimoto thyroiditis in 17% and β-blocker use in 33%. Positive predictive value for the PG test (>100 pg/mL) was 25% in the entire series. The cost of adding calcitonin measurement (±PG stimulation) to the preoperative work-up, resulted in €912.68 per MTC patient to detect the disease. CONCLUSION: Basal calcitonin measurement together with PG stimulation in cases of basal calcitonin >10 pg/mL detects MTC in 0.62% of patients with nodular thyroid disease.
Calcitonin* ; Diagnosis ; Hashimoto Disease ; Humans ; Pentagastrin ; Renal Insufficiency ; Thyroid Diseases* ; Thyroid Gland* ; Thyroid Neoplasms ; Thyroid Nodule

This is a case of a 30-year-old man who was referred to our hospital for evaluation of a rapidly growing tumor in the left thyroid gland. It was palpated 2 weeks ago. But it was growing fast. A 4x3 cm mass was palpated in the left thyroid gland. Our impression was anaplastic thyroid carcinoma. Computed tomography finding indicated a thyroid malignant tumor and cytology result suggested spindle cell neoplasm. A lower anterior neck mass was resected and final histopathological result turns out to be a rhabdomyosarcoma (RMS). Although cervical RMS is very rare in adults, it has to be included for the differential diagnosis for the rapidly growing mass at thyroid gland.
Adult ; Diagnosis, Differential ; Humans ; Neck ; Rhabdomyosarcoma* ; Thyroid Gland* ; Thyroid Neoplasms*

The BRAF(V600E) mutation is the most common genetic alteration and presents in 40~80% of all papillary thyroid cancer (PTC), showing the highest prevalence in the Korean population, close to 80%. Previous studies published in the past 10 years showed a significant correlation between BRAF(V600E) mutation and poor prognostic outcomes of PTC, including recurrence and mortality. Therefore, its clinical application for the diagnosis of thyroid nodule or for decisions regarding the management policy by prediction of the prognosis of thyroid cancer has been proposed. However, some recent studies have reported conflict results, and there appear to be growing concerns regard to the cost-benefit of tests for detection of the BRAF(V600E) mutation. In this paper, we reviewed previous studies regarding the BRAF(V600E) mutation and attempted to evaluate the clinical implication of the BRAF(V600E) mutation in clinical practice.
Diagnosis ; Mortality ; Prevalence ; Prognosis ; Recurrence ; Thyroid Neoplasms* ; Thyroid Nodule

PURPOSE: External beam radiotherapy (EBRT) plays a controversial role in the management of differentiated thyroid cancer. We reviewed the outcomes of patients at our institution who had been treated with EBRT for advanced differentiated thyroid cancer. METHODS: Subjects included 35 patients who received thyroidectomy and EBRT at Yonsei University Wonju College of Medicine, Wonju Christian Hospital under the diagnosis of papillary thyroid cancer from January 1989 to September 2011. RESULTS: The 5 year overall locoregional control rate was 74.4%. No significant differences were found in locoregional progression- free survival for patients with complete resection, microscopic residual disease, or gross residual disease. CONCLUSION: The results of our study have shown that EBRT is effective for locoregional control of selected locally advanced papillary thyroid cancer, even with gross residual disease.
Diagnosis ; Gangwon-do ; Humans ; Radiotherapy* ; Thyroid Gland* ; Thyroid Neoplasms* ; Thyroidectomy