1.Research progress on clinical diagnosis for lung metastases from differentiated thyroid carcinoma.
Huanhuan LI ; Suping LI ; Jinhui YOU
Journal of Biomedical Engineering 2014;31(4):950-954
Lung metastases are more common in metastatic disease in differentiated thyroid carcinoma (DTC). Because of its insidious onset and slow development, clinical diagnosis is relatively difficult. Some possible diagnostic methods for detecting the lung metastasis of DTC including serological examination, radionuclide imaging and other medical imaging patterns are discussed in this paper. The progress and the current situation about investigation of those modalities which are in the early diagnosis, recurrent and clinical evaluation for the lung metastasis of DTC are briefly reviewed. Therefore, it is expected to promote DTC with lung metastasis to a higher diagnostic level.
Humans
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Lung Neoplasms
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diagnosis
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secondary
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Neoplasm Metastasis
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Thyroid Neoplasms
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pathology
2.Metastasis of leiomyosarcoma to the thyroid.
Xiao-rong DENG ; Gang WANG ; Chun-jing KUANG ; Gui-zu PENG ; Ren-sheng CHEN
Chinese Medical Journal 2005;118(2):174-176
6.Papillary Thyroid Carcinoma: Bilateral Choroidal Metastases with Extrascleral Extension.
Hayyam KIRATLI ; Bercin TARLAN ; Figen SOYLEMEZOGLU
Korean Journal of Ophthalmology 2013;27(3):215-218
Here, we present the case of a patient with bilateral choroidal metastases with extraocular extension in one eye. Metastasis of papillary thyroid carcinoma to the uvea is extremely rare, with only 6 patients reported in the literature. A 62-year-old man with a prior history of papillary thyroid carcinoma suffered the rapid loss of vision in his right eye. He had neovascular glaucoma, total retinal detachment, and a solitary choroidal mass. A month later, his left visual acuity also decreased because of a small macular choroidal mass. The right eye was enucleated and a nodular lesion over the sclera representing extraocular extension was observed. This tumor and the intraocular lesion were composed of papillary excrescences and cystic spaces and stained positively for thyroid transcription factor 1 and thyroglobulin, all confirming the diagnosis of metastatic papillary thyroid carcinoma. The tumor in the left eye was successfully treated with diode laser transpupillary thermotherapy. The patient expired within a month as a result of widespread pulmonary metastases. Papillary thyroid carcinoma may metastasize to the uvea bilaterally, cause rapid visual function loss, erode the sclera, and may extend outside the globe similar to choroidal melanoma. This aggressive ocular involvement was associated with a dismal prognosis in our patient.
Carcinoma/*pathology/therapy
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Choroid/*pathology
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Choroid Neoplasms/*secondary/therapy
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Humans
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Hyperthermia, Induced
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Lung Neoplasms/secondary
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Male
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Middle Aged
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Sclera/*pathology
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Thyroid Neoplasms/*pathology/therapy
7.Synchronous Bony and Soft Tissue Metastases from Follicular Carcinoma of the Thyroid.
Gabriel RODRIGUES ; Arnab GHOSH
Journal of Korean Medical Science 2003;18(6):914-916
Follicular carcinoma of the thyroid rarely manifests itself as a distant metastatic lesion, and, when present, is usually found in flat bones. A soft tissue metastasis is extremely rare, and synchronous metastases to the bone and soft tissue is not reported in the literature so far. We report such a case of a 42-yr-old male, who presented with a goiter, scalp and forearm soft tissue swellings, and, fine needle aspiration cytology of all these swellings revealed a follicular neoplasm. A wide excision of the forearm swelling was carried out and the histopathology was consistent with features of metastatic follicular carcinoma of the thyroid. The main stay of treatment is surgical resection of the primary tumor. The various modalities of treatment of metastasis is discussed with a review of literature.
Adenocarcinoma, Follicular/*pathology/surgery
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Adult
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Bone Neoplasms/pathology/*secondary/surgery
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Human
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Male
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Soft Tissue Neoplasms/pathology/*secondary/surgery
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Thyroid Neoplasms/*pathology/surgery
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Treatment Outcome
8.Poorly Differentiated Carcinoma of the Thyroid Retrospective Clinical and mMrphologic Evaluation.
Tae Sook HWANG ; Jin Suk SUH ; Yong Il KIM ; Seong Hoe PARK ; Chang Soon KOH ; Bo Youn CHO ; Seung Keun OH
Journal of Korean Medical Science 1990;5(1):47-52
Five thyroid carcinomas showing clinically aggressive biologic behavior were retrospectively reviewed to evaluate the possible presence of morphologic differences from conventional thyroid carcinomas. They were originally diagnosed as follicular carcinomas, medullary carcinoma, papillary carcinoma, and mixed papillary and medullary carcinoma. There were three males and two females. The age at the time of initial diagnosis ranged from 36 years to 67 years (mean 56 years). The size of the tumor varied from 4.5cm to 10cm (mean diameter 7cm). One patient died of brain metastasis four years after the initial therapy and the other four patients are still alive with local recurrences and/or metastases to bone, spinal cord, lung, and buttock. Histologically these lesions are categorized into two different groups: insular variant and columnar cell variant. Insular variant was characterized by well-defined nests (insulae) that are composed of small, uniform cells, frequent tumor necrosis, and hyalinization of the stroma. Columnar cell variant was characterized by tall columnar cells with marked nuclear statification. All five cases stained positively for thyroglobulin and negatively for calcitonin. With the above clinical and histopathological findings, we interpreted these lesions as a poorly differentiated carcinoma, biologically in an intermediate position between well differentiated and anaplastic carcinomas. The rapid and often fatal outcome associated with these variants of poorly differentiated carcinoma warrants aggressive treatment at the time of diagnosis.
Adenocarcinoma/*pathology/secondary
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Adult
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Carcinoma, Papillary/*pathology/secondary
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Evaluation Studies as Topic
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Female
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Humans
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Male
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Middle Aged
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Retrospective Studies
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Thyroid Neoplasms/*pathology/secondary
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Tumor Cells, Cultured
9.Anaplastic Thyroid Carcinoma Initially Presented with Abdominal Cutaneous Mass and Hyperthyroidism.
Kyu Hyoung LIM ; Keun Wook LEE ; Jee Hyun KIM ; So Yeon PARK ; Sung Hee CHOI ; Jong Seok LEE
The Korean Journal of Internal Medicine 2010;25(4):450-453
A 63-year-old female was admitted to our hospital with a tender abdominal wall mass about 15 cm in diameter, which she had for 1 month. About 1 week earlier, the patient had also perceived a mass in the neck area. Computed tomography revealed huge thyroid and periumbilical masses. The thyroid hormone levels were consistent with a hyperthyroid state. Pathological examination of the thyroid mass was compatible with anaplastic thyroid carcinoma (ATC) and the abdominal cutaneous mass was shown to be metastatic ATC. Despite palliative radiotherapy and chemotherapy, the patient died of respiratory failure on her 63rd day of hospitalization. This case demonstrates that abdominal cutaneous metastasis and hyperthyroidism can occur as initial manifestations of ATC. To our knowledge, this is the first reported case.
Abdomen
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Female
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Humans
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Hyperthyroidism/*etiology
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Middle Aged
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Skin Neoplasms/*secondary
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Thyroid Neoplasms/pathology
10.A Case of Thyroid Metastasis Originating from Early Gastric Cancer.
Myong Hoon IHN ; Yong Jin KIM ; Jae Joon KIM ; Joo Young CHO ; So Young JIN
Journal of Korean Medical Science 2009;24(6):1230-1233
We report a rare case of thyroid metastasis from early gastric cancer with lymph node metastasis in a 63-yr old woman. She was diagnosed with metastatic adenocarcinoma one and a half years after distal subtotal gastrectomy, by fine needle aspiration (FNA) using thyroid sonography. Thyroid metastasis from gastric cancer is extremely rare, and this case is particular in that it is the first report of thyroid metastasis from early gastric cancer.
*Adenocarcinoma/pathology/secondary
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Biopsy, Fine-Needle
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Fatal Outcome
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Female
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Humans
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Lymphatic Metastasis/*pathology
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Middle Aged
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Stomach Neoplasms/*pathology
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Thyroid Neoplasms/pathology/*secondary