1.Metastasis of Colon Cancer to Medullary Thyroid Carcinoma: A Case Report.
So Jung YEO ; Kyu Jin KIM ; Bo Yeon KIM ; Chan Hee JUNG ; Seung Won LEE ; Jeong Ja KWAK ; Chul Hee KIM ; Sung Koo KANG ; Ji Oh MOK
Journal of Korean Medical Science 2014;29(10):1432-1435
Metastasis to the primary thyroid carcinoma is extremely rare. We report here a case of colonic adenocarcinoma metastasis to medullary thyroid carcinoma in a 53-yr old man with a history of colon cancer. He showed a nodular lesion, suggesting malignancy in the thyroid gland, in a follow-up examination after colon cancer surgery. Fine needle aspiration biopsy (FNAB) of the thyroid gland showed tumor cell clusters, which was suspected to be medullary thyroid carcinoma (MTC). The patient underwent a total thyroidectomy. Using several specific immunohistochemical stains, the patient was diagnosed with colonic adenocarcinoma metastasis to MTC. To the best of our knowledge, the present patient is the first case of colonic adenocarcinoma metastasizing to MTC. Although tumor-tumor metastasis to primary thyroid carcinoma is very rare, we still should consider metastasis to the thyroid gland, when a patient with a history of other malignancy presents with a new thyroid finding.
Adenocarcinoma/pathology/surgery
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Biopsy, Fine-Needle
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Carcinoma, Medullary/diagnosis/radiography/*secondary
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Colonic Neoplasms/*pathology/surgery
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Humans
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Male
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Middle Aged
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Neoplasms, Second Primary/*diagnosis
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Thyroid Gland/pathology
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Thyroid Neoplasms/diagnosis/radiography/*secondary
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Thyroid Nodule/diagnosis
2.Overcoming the Limitations of Fine Needle Aspiration Biopsy: Detection of Lateral Neck Node Metastasis in Papillary Thyroid Carcinoma.
Hak Hoon JUN ; Seok Mo KIM ; Bup Woo KIM ; Yong Sang LEE ; Hang Seok CHANG ; Cheong Soo PARK
Yonsei Medical Journal 2015;56(1):182-188
PURPOSE: Ultrasound (US) and US-guided fine needle aspiration biopsies (FNAB) are considered the modalities of choice for assessing lymph nodes suspected of containing metastases, but the sensitivity of FNAB varies and is specific to the operator. We analyzed the risk of FNAB providing false negative results of lateral neck node metastasis, and evaluated diagnostic accuracy of FNAB, in patients with papillary thyroid cancer. MATERIALS AND METHODS: FNAB was performed in 242 patients suspected of having lateral neck node metastasis on preoperative imaging. Thyroglobulin in the fine-needle aspirate washout (FNA wash-out Tg) and computed tomography enhancement (Hounsfield units) were measured. Patients with negative results on FNAB were examined by intraoperative frozen section. The false negative and true negative groups were compared. RESULTS: Of the 242 patients, 130 were confirmed as having lateral neck node metastases. In 74 patients, the metastasis was identified by FNAB. False positive results were observed in 2 patients (0.8%) and false negatives in 58 (44.6%). Risk analysis showed that patient age <45 years (p=0.006), tumor size >1 cm (p=0.008) and elevated FNA wash-out Tg (p=0.004) were significantly associated with false negative results on FNAB. The accuracy of FNAB increased significantly when combined with FNA wash-out Tg (p=0.003). CONCLUSION: To reduce the false negative rate of FNAB, patient age (<45 years), tumor size (>1 cm) and FNA wash-out Tg (>34.8 ng/mL) should be considered in preoperative planning. Accuracy may be improved by combining the results of FNAB and FNA wash-out Tg.
Adolescent
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Adult
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Aged
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Biopsy, Fine-Needle
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Carcinoma/*diagnosis/*pathology/radiography/surgery
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False Negative Reactions
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Female
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Humans
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Lymph Nodes/*pathology/radiography
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Lymphatic Metastasis/*pathology/radiography
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Male
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Middle Aged
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Multivariate Analysis
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Preoperative Care
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Risk Factors
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Sensitivity and Specificity
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Thyroglobulin/metabolism
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Thyroid Gland/*pathology
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Thyroid Neoplasms/*diagnosis/*pathology/radiography/surgery
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Tomography, X-Ray Computed
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Young Adult