Background: The interpretation of thyroid hormone function during pregnancy is difficult due to its physiologic changes. Differences in iodine status in previous studies led to different intervals; therefore the use of trimester-specific, method-specific and probably country-specific reference values is advocated. Objective: To establish trimester-specific reference interval for thyroid function tests in pregnant Filipino women. Methodology: Six hundred sixteen pregnant patients (5–40 weeks gestation) attending a tertiary center were recruited. Level of serum thyroid stimulating hormone (TSH) was measured using immunoradiometric assay while free thyroxine (FT4), free triiodothyronine (FT3) and thyroid peroxidase antibodies (TPOAb) were measured by radioimmunoassay method. Main outcome measures are trimester-specific reference interval based on 2.5th and 97.5th percentiles for TSH, FT4 and FT3 among TPOAb-negative pregnant patients. Results: The reference intervals for each trimester were as follows: TSH (0.05-4.24, 0.13-3.95, and 0.20-3.00 uIU/mL); FT4 (9.80-21.88, 9.10-18.95 and 9.16-18.64 pmol/L) and FT3 (2.40-6.20, 2.77-5.00 and 2.09-3.70 pmol/L). FT4 and FT3 are strongly and negatively correlated with age of gestation (p=<0.01and <0.01 respectively). No correlation is found with TSH and age of gestation (p=0.52). Conclusions Trimester-specific intervals among pregnant Filipino women are different from their non-pregnant counterparts and laboratory cutoffs. Thus, these reference values should be used in the country.
Thyroid Function Tests

No abstract available.
Thyroid Function Tests* ; Thyroid Gland*

No abstract available.
Thyroid Function Tests* ; Thyroid Gland*

Objective: This study aims to determine the effect of iodine excess in pregnant mothers on thyroid function, growth and neurodevelopment in the neonates when assessed at 12 weeks of age. Methodology: This prospective study enrolled term neonates with birth weight >2500 gm of mothers having urine iodine concentration (UIC) ≥500 µg/L documented in the third trimester of the peripartum period. Neonatal TSH was collected by heel prick on dried blood spots within 24-72 hours of age and measured by time-resolved fluroimmunoassay. Neonates with TSH ≥11 mIU/L at birth were followed up at 2 and 12 weeks to monitor thyroid dysfunction, growth and development. Results: A total of 2354 (n = 1575 in the delivery room) maternal urine samples were collected of which 598 (25.4%) had elevated UIC. Forty-nine (12.2%) neonates had TSH ≥11mIU/L on newborn screening of whom 18 and 3 neonates had residual elevated TSH at 2 and 12 weeks of life, respectively. Maternal iodine levels correlated weakly with TSH at 2 weeks (rho = 0.299; p = 0.037). No child required treatment for congenital hypothyroidism. Eight babies additionally had TSH >5 mIU/L at 12 weeks of life. The growth and development of babies with or without TSH elevation was comparable at three months (p > 0.05). Conclusion Maternal iodine excess in pregnancy and peripartum period causes transient hyperthyrotropinemia in neonates that did not affect the growth and development at 3 months of age.
Thyroid ; Thyroid Gland ; Hypothyroidism ; Thyroid Function Tests

The study was conducted in 82 simple goiter patients and 91 patients with Basedow’s disease after at least one year using iodized salt daily. The result showed:- The uptake of radioactive iodine (RAIU) by the thyroid gland of simple goiter and patients with Basedow’s disease decreased after 2 and 24 hours taking an oral dose of radioactive iodine, specially in simple goiter patients decreased 40-50%. -The serum concentrations of T3, T4, TSH were following: in simple goiter patients, the serum concentrations of T3 and TSH were little decreased and the T4 serum concentration was increased. However, all the values were still in the normal range of euthyroidism. In patients with Basedow’s diseased the serum concentrations of T3,T4,TSH have not been changed
Nuclear Medicine ; Thyroid Function Tests

The thyroid function was evaluated by the radio angiography. This method involved the use of intravenous Tc- 99 m gamma camera with the image display of 1 picture/ second or 2 pictures/second has been setup before. The picture and the duration of the first radioactive transfer into the carotid and duration of radioactive transfer from carotid to the thyroid were monitored to evaluate the thyroid function.
Radionuclide Angiography ; Thyroid Function Tests

Some methods of diagnosis by using the nuclear medicine have been applied in Vietnam including the functional diagnosis in vivo, the image writing and in vitro method.
Nuclear Medicine ; Thyroid Function Tests

No abstract available.
Prevalence* ; Thyroid Function Tests* ; Thyroid Gland*

The authors present the results of clinical recovering and hormonal changing at 98 patients with Basedow’ treated by I-131. The clinical clearly and quickly changed symptoms were putting on body weight, decreasing finger’s tremor, cardiovascular troubles. The volume of goiter and opthalmological signes decreasing more slowly. The seum concentrations of TSH, T3, T4, FT4 were clearly changed related to patients’s status (euthyrosis or hyperthyroidism) after treatment.
Graves Disease ; Thyroid Function Tests ; nuclear medicine

Thyrotoxicosis (thyroid crisis) is a known cause of sudden death; however, only a few cases of death resulting from thyrotoxicosis have been reported. Histopathologic examination and postmortem thyroid function tests may be helpful in postmortem diagnosis, but their usefulness seems to be limited. We report three autopsy cases associated with thyrotoxicosis.
Autopsy ; Death, Sudden ; Thyroid Crisis ; Thyroid Function Tests ; Thyrotoxicosis