1.Synthesis of benzyl pinonate and some derivatives that predicted as compounds with bioactivities
Pharmaceutical Journal 1999;282(10):11-14
From essential oil of turpentine, the author have been separated a-pinen. Some derivatives e.g pinonic acid, oxypinocamphon and benzyl pinonat have been syntherized. 7 derivatives such as oxime, hydrazone, semicarbazone, thiosemicarbazone, 2,4-dinitrophenyl hydrazone and isonicotinoyl hydrazone have been prepared
Chemical synthesis
;
Analogs & derivatives
2.Synthesis of derivatives of N-propylpiononate and investigation on biological effects
Pharmaceutical Journal 1999;282(10):17-19
From the essential oil of turpentive, the author have separated pinene. Some derivatives e.g. pinonic acid, oxypinocamphon and n-propyl pinonat were synthesized. 7 derivatives such as hydrazone, semicarbazone, thiosemicarbazone, 2,4 dinitrophenyl hydrazone and isonicotionyl hydrazone were prepared. The structures of the obtained products were characterized by elemental analyses and spectral methods (IR, UV). The biological activities of the products such as antibacterial and antifungal were tested. The results indicated that these compounds possessed biological activities, especially antibacterial activity.
Chemical synthesis
;
Analogs & derivatives
3.Synthesis the aniline's derivatives and their bioactivies
Pharmaceutical Journal 1999;282(10):11-13
The authors have performed the condensation of Vanillin with following compounds: Hydrazone, semicarbazid, thiosemicarbazid, phenylhydrazine, 2.4 -dinitronphenyhydrazine and iso- nicotinoyl hydrazine. 6 compounds derivatives have been synthesized. The structures of the obtained products were characterized by spectral methods(IR,UV). The biological activities of the resulting products as antibacterial and antifungal have been tested. The results indicated these compounds possessed high biological activities, especially antibacterial activity.
Chemical synthesis
;
Analogs & derivatives
4.An Outbreak of Trichinosis with Molecular Identification of Trichinella sp. in Vietnam.
Nguyen Van DE ; Nguyen Vu TRUNG ; Nguyen Hong HA ; Vu Thi NGA ; Nguyen Minh HA ; Pham Thanh THUY ; Le Van DUYET ; Jong Yil CHAI
The Korean Journal of Parasitology 2012;50(4):339-343
The 5th outbreak of trichinosis occurred in a mountainous area of North Vietnam in 2012, involving 24 patients among 27 people who consumed raw pork together. Six of these patients visited several hospitals in Hanoi for treatment. Similar clinical symptoms appeared in these patients within 5-8 days after eating infected raw pork, which consisted of fever, muscle pain, difficult moving, edema, difficult swallowing, and difficult breathing. ELISA revealed all (6/6) positive reactions against Trichinella spiralis antigen and all cases showed positive biopsy results for Trichinella sp. larvae in the muscle. The larvae detected in the patients were identified as T. spiralis (Vietnamese strain) by the molecular analysis of the mitochondrial cytochrome c oxidase subunit III (cox3) gene.
Adult
;
Animals
;
Antigens, Helminth/analysis/immunology
;
*Disease Outbreaks
;
Electron Transport Complex IV/genetics
;
Enzyme-Linked Immunosorbent Assay
;
Female
;
Humans
;
Larva
;
Male
;
Meat/*parasitology
;
Mitochondria/genetics
;
Muscles/parasitology/pathology
;
Swine
;
Trichinella spiralis/genetics/immunology/*isolation & purification
;
Trichinellosis/*epidemiology/parasitology/pathology
;
Vietnam/epidemiology
5.Isolation and toxicity of Xanthomonas oryzae pv. oryzae in rice and a collection of phages against the pathogen
Ngoc Quynh Anh Pham ; Vo Thanh Phuc ; Pham Do Tra My ; Le Thi My Duyen ; To Hue Ngoc ; Nguyen Minh Thien ; Nguyen Hai Duong ; Le Thi Thuy Tien ; Le Phi Nga ; Hoang Anh Hoang
Malaysian Journal of Microbiology 2024;20(no.1):15-23
Aims:
The objective of the study was to isolate bacteriophages and conduct a comprehensive analysis of their potential against Xanthomonas oryzae pv. oryzae (Xoo) strains in the Mekong Delta, Vietnam.
Methodology and results:
Twelve Xoo strains were isolated from rice fields located in the Mekong Delta, Vietnam. Among these strains, three strains Xoo L019, L020 and L024, showed the highest disease index of bacterial blight. Four
phages specific to Xoo were isolated from soil, water and leaf samples, and their morphologies were determined. In a test against 12 Xoo strains, phage L541, MLA23 or W41 could infect 10 of the 12 Xoo strains, while phage LBH01 could infect 8 of the 12 Xoo strains. The stability of the phages to pH, organic solvents, UV-A and UV-B was also evaluated.
Conclusion, significance and impact of study
The initial characterization of the phages indicates their potential as biocontrol agents against bacterial blight in rice. The study is one of the very first studies about Xoo phages in rice in Vietnam.
6.Impact of long COVID-19 on posttraumatic stress disorderas modified by health literacy: an observational study inVietnam
Han Thi VO ; Tien Duc DAO ; Tuyen Van DUONG ; Tan Thanh NGUYEN ; Binh Nhu DO ; Tinh Xuan DO ; Khue Minh PHAM ; Vinh Hai VU ; Linh Van PHAM ; Lien Thi Hong NGUYEN ; Lan Thi Huong LE ; Hoang Cong NGUYEN ; Nga Hoang DANG ; Trung Huu NGUYEN ; Anh The NGUYEN ; Hoan Van NGUYEN ; Phuoc Ba NGUYEN ; Hoai Thi Thanh NGUYEN ; Thu Thi Minh PHAM ; Thuy Thi LE ; Thao Thi Phuong NGUYEN ; Cuong Quoc TRAN ; Kien Trung NGUYEN
Osong Public Health and Research Perspectives 2024;15(1):33-44
Objectives:
The prevalence of posttraumatic stress disorder (PTSD) has increased, particularly among individuals who have recovered from coronavirus disease 2019 (COVID-19) infection. Health literacy is considered a “social vaccine” that helps people respond effectively to the pandemic. We aimed to investigate the association between long COVID-19 and PTSD, and to examine the modifying role of health literacy in this association.
Methods:
A cross-sectional study was conducted at 18 hospitals and health centers in Vietnamfrom December 2021 to October 2022. We recruited 4,463 individuals who had recovered from COVID-19 infection for at least 4 weeks. Participants provided information about their sociodemographics, clinical parameters, health-related behaviors, health literacy (usingthe 12-item short-form health literacy scale), long COVID-19 symptoms and PTSD (Impact Event Scale-Revised score of 33 or higher). Logistic regression models were used to examine associations and interactions.
Results:
Out of the study sample, 55.9% had long COVID-19 symptoms, and 49.6% had PTSD.Individuals with long COVID-19 symptoms had a higher likelihood of PTSD (odds ratio [OR], 1.86; 95% confidence interval [CI], 1.63–2.12; p < 0.001). Higher health literacy was associated with a lower likelihood of PTSD (OR, 0.98; 95% CI, 0.97–0.99; p = 0.001). Compared to those without long COVID-19 symptoms and the lowest health literacy score, those with long COVID-19 symptoms and a 1-point health literacy increment had a 3% lower likelihood of PTSD (OR, 0.97; 95% CI, 0.96–0.99; p = 0.001).
Conclusion
Health literacy was found to be a protective factor against PTSD and modified the negative impact of long COVID-19 symptoms on PTSD.
7.Management of Antibiotic-Resistant Helicobacter pylori Infection: Perspectives from Vietnam
Vu VAN KHIEN ; Duong Minh THANG ; Tran Manh HAI ; Nguyen Quang DUAT ; Pham Hong KHANH ; Dang Thuy HA ; Tran Thanh BINH ; Ho Dang Quy DUNG ; Tran Thi Huyen TRANG ; Yoshio YAMAOKA
Gut and Liver 2019;13(5):483-497
Antibiotic resistance is the most important factor leading to the failure of eradication regimens. This review focuses on the prevalence of Helicobacter pylori primary and secondary resistance to clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug in Vietnam. We searched the PubMed, EMBASE, Vietnamese National Knowledge Infrastructure, and Vietnamese Biomedical databases from January 2000 to December 2016. The search terms included the following: H. pylori infection, antibiotic (including clarithromycin, metronidazole, amoxicillin, levofloxacin, tetracycline, and multidrug) resistance in Vietnam. The data were summarized in an extraction table and analyzed manually. Finally, Excel 2007 software was used to create charts. Ten studies (three studies in English and seven in Vietnamese) were included in this review. A total of 308, 412, 523, 408, 399, and 268 H. pylori strains were included in this review to evaluate the prevalence of H. pylori primary resistance to amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance, respectively. Overall, the primary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 15.0%, 34.1%, 69.4%, 27.9%, 17.9% and 48.8%, respectively. Secondary resistance rates of amoxicillin, clarithromycin, metronidazole, levofloxacin, tetracycline, and multidrug resistance were 9.5%, 74.9%, 61.5%, 45.7%, 23.5% and 62.3%, respectively. In Vietnam, primary and secondary resistance to H. pylori is increasing over time and affects the effectiveness of H. pylori eradication.
Amoxicillin
;
Asian Continental Ancestry Group
;
Bismuth
;
Clarithromycin
;
Drug Resistance, Microbial
;
Drug Resistance, Multiple
;
Helicobacter pylori
;
Helicobacter
;
Humans
;
Levofloxacin
;
Metronidazole
;
Prevalence
;
Tetracycline
;
Vietnam
8.Comparing multiplex and multiplex real-time polymerase chain reaction with traditional blood culture in bacterial detection among patients with septicemia
Loan Thi Nguyen ; Linh Trong Nguyen ; Trang Thu Nguyen ; Hien Minh Nguyen ; Thuy Thi Pham ; Huyen Thi La
Malaysian Journal of Microbiology 2022;18(3):242-250
Aims:
This study was aimed to test the specificity of primers and probes with target genes by using multiplex PCR and multiplex real-time PCR methods. These methods were compared with traditional blood culture methods in detecting five bacteria causing sepsis, including Acinetorbacter baumannii, Klebsiella pneumoniae, Pseudomonas aeruginosa, Escherichia coli and Staphylococcus aureus.
Methodology and results:
A total of 587 blood samples from patients diagnosed with sepsis and septic shock were collected at Thanh Nhan Hospital, Hanoi, Vietnam. Each sample was divided into three parts for bacterial culture, multiplex PCR and multiplex real-time PCR to detect the similarity of the two PCR methods with the bacterial culture method. Conditions in multiplex PCR and multiplex real-time PCR were optimized to ensure the successful amplification of target genes. Results showed that the primers and probes were tested completely specific to the target genes and using multiplex PCR and multiplex real-time PCR techniques could detect five pathogens causing sepsis, including A. baumannii, K. pneumoniae, P. aeruginosa, E. coli and S. aureus.
Conclusion, significance and impact of study
Both multiplex PCR and multiplex real-time PCR methods have high similarities with the culture method, showing potential in the application of bacteria detection in sepsis.
Multiplex Polymerase Chain Reaction
;
Sepsis--microbiology