A series of 135 cases of pterygium observed at the Eye Dept. in the National Medical Center from April 1963 to May 1966, were treated with thio-tepa after the surgical removal and were studied clinically in regard to the incidence of the recurrence. Among the total series, only one case showed no response to the thio-tepa instillation and the recurrence persisted. There was a case of allergic response to the thio-tepa, which has not been found in any reports known. No serious local or systemic toxcity or any sequelae such as corneal damages, defective vision or the interference with wound healing could be observed.
Incidence ; Korea* ; Pterygium ; Recurrence ; Thiotepa ; Wound Healing

Condyloma acuminatum is a common lesion of the penis and genitalia. It uncommonly involves the urethra but when it does the lesions are difficult to eradicate. Treatment has included excision, fiuguration, podophyline and thiotepa0 none of which has been entirely successful. We report a case of intraurethral condyloma acuminatum treated with thiotepa instillation in 27 years old male patient
Adult ; Genitalia ; Humans ; Male ; Penis ; Thiotepa* ; Urethra

Study group consists of 30 cases whose follow-up period is over 6 months among 32 cases of bladder tumors treated with thio-TEPA instillation following TUR during the period from January, 1978 through June, 1981. Control group consists of 25 cases whose follow-up period is over 6 months among 33 cases of bladder tumors treated by TUR only during the period from January, 1971 through December, 1977. Following results were obtained: 1. Recurrence rate: In study group, 30% In control group, 64% 2. Interval between TUR & the first recurrence: In study group, average 8.1 months In control group, average 7.1 months 3. Number of tumors at first recurrence: In study group: 89%: under 2 11%: over 3 In control group: 25%: under 2 75%: over 3
Follow-Up Studies ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Clinical observation was male on 20 cases of bladder tumors treated by thio-TEPA instillations fo1lowing TUR during the period from January, 1978 through September, 1979 and the following results were obtained. Among 20 cases of bladder tumor. 1) 7cases have been followed up without recurrence. 2) 4 cages have been followed up without recurrence with instillations, who had previous recurrences following T.U.R. only. 3) 4 cases recurred in spite of 4 thio-TEPA instillations. 4) 5 cases were not followed up sufficiently.
Humans ; Male ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

The results of cryotherapy for 12 cases with the tendency of recurrent pterygium treated with Thio-tepa or strontium 90 after the surgical removal are presented. There appeared the rupture of vessels. and edema following cryocautery for: 3~15 days. No special complication or any sequelae in the eyeball is observed. The irritatini signs such as foreign body sensation, lacrimation or photophobia are easily relieved with systemic treatment of Celestamin tablet.
Cryotherapy ; Edema ; Foreign Bodies ; Photophobia ; Pterygium* ; Rupture ; Sensation ; Strontium ; Thiotepa

Intravesical thio-tepa instillations for 25 patients with superficial bladder tumors were evaluated postoperatively to reconfirm its usefulness as a prophylactic agent. The over-all recurrence rate to prophylactic thio-tepa was 28%, with minor toxicity observed in 32% of the Cases. Thio-tepa Can be given safely in the postoperative period and is effective in decreasing the recurrence rate and prolonging interval free of disease of superficial bladder tumors.
Humans ; Postoperative Period ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Intravesical thio-tepa instillations for 25 patients with superficial bladder tumors were evaluated postoperatively to reconfirm its usefulness as a prophylactic agent. The over-all recurrence rate to prophylactic thio-tepa was 28%, with minor toxicity observed in 32% of the Cases. Thio-tepa Can be given safely in the postoperative period and is effective in decreasing the recurrence rate and prolonging interval free of disease of superficial bladder tumors.
Humans ; Postoperative Period ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Local instillation of Thio-tepa (triethylene thiophosphoramide) is widely used as an important adjunct in the management of papilloma of the bladder. We herein report the 10 case of the bladder cancer administered with Thio-tepa for the treatment and prophylaxis.
Administration, Intravesical* ; Papilloma ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Superficial bladder tumors are usually treated by TUR. However, recurrence of the tumor after complete resection occurs in about 50-70%, of the patients with a significant percentage of these recurrences showing a higher degree of malignancy. In 10% of the cases, the tumor progresses to invasive carcinoma. Most of these recurrent tumors will occur within 6-12 months. The multifocal nature of these tumors and the frequent recurrences after TUR indicate a need for adjuvant chemotherapy to reduce or delay the incidence of recurrence tumors. We studied to evaluate prophylactic effects of topical chemotherapy in 116 cases with superficial bladder tumors admitted to the Department of Urology, Keimyung University School of Medicine during the period from Jenuary, 1971 through July, 1985. All patients were followed up for more than 6 months. Study group consists of 83 cases (Thio-tepa: 39, Adriamycin; 44) treated with topical chemotherapy following TUR during the period from January, 1978 through July, 1985. Control group consists of 33 cases treated by TUR only during the period from January 1971 through December, 1977. Following results were obtained: 1. No. of patients with recurrence; In study group, 36Pr In control group. 67% 2. Average interval of recurrence: In study group, 38 months. In control group, 30 months 3. Recurrence rate; In study group, 2.58 In control group, 3.16 4. Complication: local side effects; In TUR + Thio-tepa, 20.5% In TUR + Adriamycin, 15.9%.
Chemotherapy, Adjuvant ; Doxorubicin ; Drug Therapy* ; Humans ; Incidence ; Recurrence ; Thiotepa ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urology

We tried to treat 16 patients with superficial transitional cell carcinoma of the bladder with prophylactic and therapeutic intravesical chemotherapy. The 2 drugs used were adriamycin and thio-tepa and checked for efficacy by repeated cystoscopy with at least 3 months` interval. The clinical data and results of both groups are presented and the importance of intravesical treatment with minimal toxicity is discussed with a brief review of the literatures.
Carcinoma, Transitional Cell ; Cystoscopy ; Doxorubicin ; Drug Therapy* ; Humans ; Thiotepa ; Urinary Bladder Neoplasms* ; Urinary Bladder*