A series of 135 cases of pterygium observed at the Eye Dept. in the National Medical Center from April 1963 to May 1966, were treated with thio-tepa after the surgical removal and were studied clinically in regard to the incidence of the recurrence. Among the total series, only one case showed no response to the thio-tepa instillation and the recurrence persisted. There was a case of allergic response to the thio-tepa, which has not been found in any reports known. No serious local or systemic toxcity or any sequelae such as corneal damages, defective vision or the interference with wound healing could be observed.
Incidence ; Korea* ; Pterygium ; Recurrence ; Thiotepa ; Wound Healing

Condyloma acuminatum is a common lesion of the penis and genitalia. It uncommonly involves the urethra but when it does the lesions are difficult to eradicate. Treatment has included excision, fiuguration, podophyline and thiotepa0 none of which has been entirely successful. We report a case of intraurethral condyloma acuminatum treated with thiotepa instillation in 27 years old male patient
Adult ; Genitalia ; Humans ; Male ; Penis ; Thiotepa* ; Urethra

Clinical observation was male on 20 cases of bladder tumors treated by thio-TEPA instillations fo1lowing TUR during the period from January, 1978 through September, 1979 and the following results were obtained. Among 20 cases of bladder tumor. 1) 7cases have been followed up without recurrence. 2) 4 cages have been followed up without recurrence with instillations, who had previous recurrences following T.U.R. only. 3) 4 cases recurred in spite of 4 thio-TEPA instillations. 4) 5 cases were not followed up sufficiently.
Humans ; Male ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

The results of cryotherapy for 12 cases with the tendency of recurrent pterygium treated with Thio-tepa or strontium 90 after the surgical removal are presented. There appeared the rupture of vessels. and edema following cryocautery for: 3~15 days. No special complication or any sequelae in the eyeball is observed. The irritatini signs such as foreign body sensation, lacrimation or photophobia are easily relieved with systemic treatment of Celestamin tablet.
Cryotherapy ; Edema ; Foreign Bodies ; Photophobia ; Pterygium* ; Rupture ; Sensation ; Strontium ; Thiotepa

Local instillation of Thio-tepa (triethylene thiophosphoramide) is widely used as an important adjunct in the management of papilloma of the bladder. We herein report the 10 case of the bladder cancer administered with Thio-tepa for the treatment and prophylaxis.
Administration, Intravesical* ; Papilloma ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Study group consists of 30 cases whose follow-up period is over 6 months among 32 cases of bladder tumors treated with thio-TEPA instillation following TUR during the period from January, 1978 through June, 1981. Control group consists of 25 cases whose follow-up period is over 6 months among 33 cases of bladder tumors treated by TUR only during the period from January, 1971 through December, 1977. Following results were obtained: 1. Recurrence rate: In study group, 30% In control group, 64% 2. Interval between TUR & the first recurrence: In study group, average 8.1 months In control group, average 7.1 months 3. Number of tumors at first recurrence: In study group: 89%: under 2 11%: over 3 In control group: 25%: under 2 75%: over 3
Follow-Up Studies ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Intravesical thio-tepa instillations for 25 patients with superficial bladder tumors were evaluated postoperatively to reconfirm its usefulness as a prophylactic agent. The over-all recurrence rate to prophylactic thio-tepa was 28%, with minor toxicity observed in 32% of the Cases. Thio-tepa Can be given safely in the postoperative period and is effective in decreasing the recurrence rate and prolonging interval free of disease of superficial bladder tumors.
Humans ; Postoperative Period ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Intravesical thio-tepa instillations for 25 patients with superficial bladder tumors were evaluated postoperatively to reconfirm its usefulness as a prophylactic agent. The over-all recurrence rate to prophylactic thio-tepa was 28%, with minor toxicity observed in 32% of the Cases. Thio-tepa Can be given safely in the postoperative period and is effective in decreasing the recurrence rate and prolonging interval free of disease of superficial bladder tumors.
Humans ; Postoperative Period ; Recurrence ; Thiotepa* ; Urinary Bladder Neoplasms* ; Urinary Bladder*

We tried to treat 16 patients with superficial transitional cell carcinoma of the bladder with prophylactic and therapeutic intravesical chemotherapy. The 2 drugs used were adriamycin and thio-tepa and checked for efficacy by repeated cystoscopy with at least 3 months` interval. The clinical data and results of both groups are presented and the importance of intravesical treatment with minimal toxicity is discussed with a brief review of the literatures.
Carcinoma, Transitional Cell ; Cystoscopy ; Doxorubicin ; Drug Therapy* ; Humans ; Thiotepa ; Urinary Bladder Neoplasms* ; Urinary Bladder*

Recurrence in patients with superficial bladder tumor is a serious problem. In one series, the recurrence rate was 73%, and invasive cancer developed in 10% of patients with recurrences. To eliminate or reduce the rate of recurrence, topical chemotherapy has been tried and showed adjunct effects. We studied to evaluate prophylactic effects of topical chemotherapy in 51 patients with superficial bladder tumor admitted to the Department of Urology, Kyung Hee University Hospital during the period from April, 1979 to April, 1984. Patients were divided into 2 groups. Group A comprised 19 patients (Adriamycin; 8, Thio-TEPA; 11) treated with topical chemotherapy following initial TUR and 27 patients treated by TUR only. Group B comprised 5 patients treated with topical chemotherapy (Adriamycin) after repeated TUR and 7 patients among 27 patients who had repeated TUR for recurrence. Patients treated by TUR only were defined as control group. Recurrence rate was analyzed in each group. Following results were obtained. 1. In group A, recurrence rate was 2.54 in patients with chemotherapy comparing to 3.35 in control patients. Average interval of recurrence was 39.3 months in chemotherapy patients and 29.8 months in control patients. 2. In group B, recurrence rate was higher in chemotherapy patients than in control patients with rate of 6.6 and 5.3, respectively. But recurrence rate was diminished to 6.6 after chemotherapy comparing to pre-chemotherapy period (10.3). 3. There was no difference in recurrence rate relating to multiplicity of tumor as a whole.
Drug Therapy* ; Humans ; Recurrence ; Thiotepa ; Urinary Bladder Neoplasms* ; Urinary Bladder* ; Urology