The Aims of this study were to investigate to the role of Helicobacter pylori (H. pylori) eradication in cases of perforated peptic ulcer treated by simple surgical closure. In a large prospective study, these patients with H. pylori positive were evaluated before and after H. pylori eradication (>2 months and >1 year). Changes of gastric mocosal histopathology were assessed. Results: Improvement or resolution on the outcome of gastritis and atrophy (P<0.001) demonstrated the efficacy of eradication therapy but intestinal metaplasia did not change. Conclusions: After successful eradication of H. pylori, these lesions were restored significantly, but intestinal metaplasia is questionable
Helicobacter pylori ; Peptic Ulcer

98 patients with perforated peptic ulcer were treated by simple surgical closure followed by H.pylori eradication. Effect of H.pylori eradication was demonstrated by improvement or resolution of histopathological lesions of chronic gastritis 97.95% compared with 60.2% in pre and postreatment lesions (p<0.0001), atrophy 20.83% vs 4.16% (p<0.0001) and intestinal metaplasia 18.75% vs 9.37% (p < 0.005). After successful eradication of H.pylori, these lesions were restored and improved significantly in patients received a new triple therapy for 7 days (OCA-7).
Peptic Ulcer ; Helicobacter pylori ; surgery

170 patients with perforated peptic ulcer (90% perforated duodenal ulcer and 10% perforated gastric ulcer) were included in the study from 8/1998 to 8/1999 at the Cho Ray hospital, Ho Chi Minh city. 165 patients (97.05%) were treated by simple surgical closure (including by one laparoscopic repair) with a postoperative mortality of 4.84%. 4 of them were treated by subtotal gastrectomy and one by vagotomy+ pyloroplasty without mortality. In summary, simple surgical closure is a satisfactory operation for most patients.
Peptic ulcer ; therapeutics ; surgery

Of 115 patients with perforated peptic ulcer, 96,5% (111/115) were treated by simple surgical closure followed by Helicobacter pylori (H.pylori) eradication. 111 H.pylori positive patients received triple therapy including Omeprazole 20 mg b.d + Clarithromycine 500mg b.d + Amoxicillin 1,000 mg b.d for 7 days (OCA-7). Follow -up endoscopiy was performed over 2 month and over 1 year after hospital discharge for surveillance of ulcer healing and determination of H.pylori status. Of 107 patients who did underwent follow-up endoscopy, 95.3% (102/107) had H.pylori eradicated and initial ulcer healing rate was 92.5% (99/107). After over 1 year, H. pylori reinfection rate was 16.8% (16/95) and ulcer ralapse rate was 7.4% (7/95). The simple surgical closure followed by H.pylori eradication prevents ulcer recurrence in patients with H.pylori associated perforated peptic ulcers.
Peptic ulcer ; Helicobacter pylori ; surgery

The Drug and treatment Council of Cho Ray hospital have been established since April 1997, which have 11 main members including doctors and presentations of functional division, purpose of Council is to fully supply drugs with quality guarantee for emergency and treatment. Council has been developed and performed some missions in 2 years as follows: (1) have built standard outlines. (2) Supply, deliver, and manage drugs, in which drug was supplied by bid. (3) Prescription, drug use, information of Adverse Drug Reaction included control of drug prescription and information activities of drugs.
Pharmaceutical Preparations ; therapeutics

Background: Postperitoneal tumors are diseases that are difficult diagnosis, vague and unspecific clinical signs. Objective: To take out experience for clinical practice based on clinical, imaging diagnosis, pathological characteristics and management for postperitoneal tumors. Subjects and method: A retrospective study included 93 cases that diagnosed and treated for postperitoneal tumors at Cho Ray Hospital from January 2000 to November 2006. Clinical, subclinical characteristics and theirs related factors; diagnosis, operation and prognosis for postperitoneal tumors were analysed. Results: The patients\ufffd?average age was 49.98\xb116.37 years (ranged 1-85 years); the ratio of male to female was 0.86. The average time from having pain symptom to admitting hospital was 4.49\xb110.01 months (ranged from 3 days to 60 months). Clinical symptoms were fatigue (51.5%), fever (15%), jaundice (45%), anemia (23.5%), weight loss (58%), abdominal pain (75%), abdominal distention (39%), digestive disorders (31%), touching tumor (50.5%)\ufffd?The diagnosis at admitting were right (32%), wrong (60%) and unclear (8%); the preoperative diagnosis were 70%, 22% and 8%, respectively. Pathologically, 39 of 93 cases (42%) were benign tumors, and 58% were malignant tumors. 61.3% of cases removed completely tumors, 2.15% removed partially tumors. The postoperative outcomes were good (62.6%), unimproved (28.57%), and bad (3.29%). There were some complications, included perioperative bleeding (2 cases - 2.19%), postoperative complication (3 cases - 3.29%), cracked colonic junction (1 case), renal bleeding (1 case) and peritonitis (1 case). Conclusions: The surgical treatment was main method for postperitoneal tumors. The complete tumor removing based on tumor\u2019s nature, stage and related structures.
Retroperitoneal Neoplasms/ surgery ; therapy ; diagnosis ; epidemiology ;

Introduction: Quality control in medical laboratory includes internal quality control and external quality control is very necessary for the quality management of medical laboratory tests. However, many laboratories for different reasons have not carried out quality control, its benefits, as well as inadequately evaluated affected risks of laboratory test quality. \r\n', u'Objectives: Two objectives are set for the research. First, to evaluate the quality of blood biochemical tests in some of the provinces, districts and private laboratories in the North of Vietnam. Second, factors that affect the quality of the medical laboratory tests are also examined. \r\n', u'Subjects and method: In this study, human control serum of Biorad is sent as ordinary blood samples to the 6 provincial, 12 district and 10 private laboratories to analyze some normal blood biomedical indexes. We also collected the necessary information on staff, equipments, and chemicals\u2026of the laboratories.\r\n', u'Results: There are five main findings in the areas of (1) general information about the laboratories, (2) laboratory test results of blood biochemical indexes with true value at the normal level, (3) laboratory test results of blood biochemical indexes with true value at the pathological level (level 2), (4) the accuracy of laboratory test results based on the blood test sample level 1, (5) the accuracy of laboratory test results based on the blood test sample level 2. In general, the first results of analyzed biomedical indexes are very different by statistical calculation between laboratories. \r\n', u'Conclusion: The research results indicated that the quality of analyzed biomedical indexes in some laboratories is not ensured. It is necessary to find the reasons and the ways to resolve the problem. \r\n', u'
Quality control ; Clinical test

In this report we describe a new approach in HIV sentinel surveillance that was piloted in Viet Nam in 2009 and is currently being rolled out in all provinces. It comprises a brief behavioural questionnaire added to the HIV sentinel surveillance surveys conducted routinely among people who inject drugs, female sex workers and men who have sex with men. Timely reporting of data from this system has resulted in improvements to HIV prevention efforts for most at-risk populations.

In this study, twenty-five yeast strains were isolated from soil samples collected in the gold mining ore in Gia Lai, Vietnam. Among them, one isolate named GL1 T could highly tolerate Cu 2+ up to 10 mM, and the isolates could also grow in a wide range of pH (3–7), and tem perature (10–40 ℃). Dried biomass of GL1 was able to remove Cu 2+ effectively up to 90.49% with a maximal biosorption capacity of 18.1 mg/g at pH 6, temperature 30 ℃, and incuba tion time 60 min. Sequence analysis of rDNA indicated this strain was closely related to Rhodotorula mucilaginosa but with 1.53 and 3.46% nucleotide differences in the D1/D2 domain of the 28S rRNA gene and the ITS1-5.8S rRNA gene-ITS2 region sequence, respect ively. Based on phylogenetic tree analysis and the biochemical characteristics, the strain appears to be a novel Rhodotorula species, and the name Rhodotorula aurum sp. nov. is pro posed. This study provides us with more information about heavy metal-tolerant yeasts and it may produce a new tool for environmental control and metal recovery operations.

Purpose: Although some immune protection from close contact with individuals who have coronavirus disease 2019 (COVID-19) has been documented, there is limited data on the seroprevalence of antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals who were in lockdown with confirmed COVID-19 cases. This study investigated immunogenicity against SARS-CoV-2 in household members and people who lived near home-quarantined patients with COVID-19. Materials and Methods: This cross-sectional study was conducted during the community-based care that took place during lockdowns in District 10, Ho Chi Minh City, Vietnam from July to September 2021. SARS-CoV-2 antibody levels were determined in index cases of COVID-19, household contacts, and a no-contact group from the same area. Results: A total of 770 participants were included (355 index cases, 103 household contacts, and 312 no contacts). All index cases were unvaccinated, but >90% of individuals in the household and no-contact groups had received ≥1 vaccine dose. SARS-CoV-2 neutralizing antibodies (Nabs) were present in >77% of unvaccinated index cases versus 64%/65.4% in the householdo-contact groups (p=0.001). Antibody concentrations in unvaccinated index cases were significantly higher than those in household contacts and no contacts, with no difference between the latter groups. In all cases, antibody levels declined markedly ≥6 weeks after infection, and failed to persist beyond this time in the household and no-contact groups. Conclusion Community-based care may have helped to create community immunogenicity, but Nabs did not persist, highlighting a need for vaccination for all individuals before, or from 6 weeks after, infection with SARS-CoV-2.