The Aims of this study were to investigate to the role of Helicobacter pylori (H. pylori) eradication in cases of perforated peptic ulcer treated by simple surgical closure. In a large prospective study, these patients with H. pylori positive were evaluated before and after H. pylori eradication (>2 months and >1 year). Changes of gastric mocosal histopathology were assessed. Results: Improvement or resolution on the outcome of gastritis and atrophy (P<0.001) demonstrated the efficacy of eradication therapy but intestinal metaplasia did not change. Conclusions: After successful eradication of H. pylori, these lesions were restored significantly, but intestinal metaplasia is questionable
Helicobacter pylori ; Peptic Ulcer

98 patients with perforated peptic ulcer were treated by simple surgical closure followed by H.pylori eradication. Effect of H.pylori eradication was demonstrated by improvement or resolution of histopathological lesions of chronic gastritis 97.95% compared with 60.2% in pre and postreatment lesions (p<0.0001), atrophy 20.83% vs 4.16% (p<0.0001) and intestinal metaplasia 18.75% vs 9.37% (p < 0.005). After successful eradication of H.pylori, these lesions were restored and improved significantly in patients received a new triple therapy for 7 days (OCA-7).
Peptic Ulcer ; Helicobacter pylori ; surgery

170 patients with perforated peptic ulcer (90% perforated duodenal ulcer and 10% perforated gastric ulcer) were included in the study from 8/1998 to 8/1999 at the Cho Ray hospital, Ho Chi Minh city. 165 patients (97.05%) were treated by simple surgical closure (including by one laparoscopic repair) with a postoperative mortality of 4.84%. 4 of them were treated by subtotal gastrectomy and one by vagotomy+ pyloroplasty without mortality. In summary, simple surgical closure is a satisfactory operation for most patients.
Peptic ulcer ; therapeutics ; surgery

Of 115 patients with perforated peptic ulcer, 96,5% (111/115) were treated by simple surgical closure followed by Helicobacter pylori (H.pylori) eradication. 111 H.pylori positive patients received triple therapy including Omeprazole 20 mg b.d + Clarithromycine 500mg b.d + Amoxicillin 1,000 mg b.d for 7 days (OCA-7). Follow -up endoscopiy was performed over 2 month and over 1 year after hospital discharge for surveillance of ulcer healing and determination of H.pylori status. Of 107 patients who did underwent follow-up endoscopy, 95.3% (102/107) had H.pylori eradicated and initial ulcer healing rate was 92.5% (99/107). After over 1 year, H. pylori reinfection rate was 16.8% (16/95) and ulcer ralapse rate was 7.4% (7/95). The simple surgical closure followed by H.pylori eradication prevents ulcer recurrence in patients with H.pylori associated perforated peptic ulcers.
Peptic ulcer ; Helicobacter pylori ; surgery

The Drug and treatment Council of Cho Ray hospital have been established since April 1997, which have 11 main members including doctors and presentations of functional division, purpose of Council is to fully supply drugs with quality guarantee for emergency and treatment. Council has been developed and performed some missions in 2 years as follows: (1) have built standard outlines. (2) Supply, deliver, and manage drugs, in which drug was supplied by bid. (3) Prescription, drug use, information of Adverse Drug Reaction included control of drug prescription and information activities of drugs.
Pharmaceutical Preparations ; therapeutics

Background: Postperitoneal tumors are diseases that are difficult diagnosis, vague and unspecific clinical signs. Objective: To take out experience for clinical practice based on clinical, imaging diagnosis, pathological characteristics and management for postperitoneal tumors. Subjects and method: A retrospective study included 93 cases that diagnosed and treated for postperitoneal tumors at Cho Ray Hospital from January 2000 to November 2006. Clinical, subclinical characteristics and theirs related factors; diagnosis, operation and prognosis for postperitoneal tumors were analysed. Results: The patients\ufffd?average age was 49.98\xb116.37 years (ranged 1-85 years); the ratio of male to female was 0.86. The average time from having pain symptom to admitting hospital was 4.49\xb110.01 months (ranged from 3 days to 60 months). Clinical symptoms were fatigue (51.5%), fever (15%), jaundice (45%), anemia (23.5%), weight loss (58%), abdominal pain (75%), abdominal distention (39%), digestive disorders (31%), touching tumor (50.5%)\ufffd?The diagnosis at admitting were right (32%), wrong (60%) and unclear (8%); the preoperative diagnosis were 70%, 22% and 8%, respectively. Pathologically, 39 of 93 cases (42%) were benign tumors, and 58% were malignant tumors. 61.3% of cases removed completely tumors, 2.15% removed partially tumors. The postoperative outcomes were good (62.6%), unimproved (28.57%), and bad (3.29%). There were some complications, included perioperative bleeding (2 cases - 2.19%), postoperative complication (3 cases - 3.29%), cracked colonic junction (1 case), renal bleeding (1 case) and peritonitis (1 case). Conclusions: The surgical treatment was main method for postperitoneal tumors. The complete tumor removing based on tumor\u2019s nature, stage and related structures.
Retroperitoneal Neoplasms/ surgery ; therapy ; diagnosis ; epidemiology ;

Introduction: Quality control in medical laboratory includes internal quality control and external quality control is very necessary for the quality management of medical laboratory tests. However, many laboratories for different reasons have not carried out quality control, its benefits, as well as inadequately evaluated affected risks of laboratory test quality. \r\n', u'Objectives: Two objectives are set for the research. First, to evaluate the quality of blood biochemical tests in some of the provinces, districts and private laboratories in the North of Vietnam. Second, factors that affect the quality of the medical laboratory tests are also examined. \r\n', u'Subjects and method: In this study, human control serum of Biorad is sent as ordinary blood samples to the 6 provincial, 12 district and 10 private laboratories to analyze some normal blood biomedical indexes. We also collected the necessary information on staff, equipments, and chemicals\u2026of the laboratories.\r\n', u'Results: There are five main findings in the areas of (1) general information about the laboratories, (2) laboratory test results of blood biochemical indexes with true value at the normal level, (3) laboratory test results of blood biochemical indexes with true value at the pathological level (level 2), (4) the accuracy of laboratory test results based on the blood test sample level 1, (5) the accuracy of laboratory test results based on the blood test sample level 2. In general, the first results of analyzed biomedical indexes are very different by statistical calculation between laboratories. \r\n', u'Conclusion: The research results indicated that the quality of analyzed biomedical indexes in some laboratories is not ensured. It is necessary to find the reasons and the ways to resolve the problem. \r\n', u'
Quality control ; Clinical test

In this report we describe a new approach in HIV sentinel surveillance that was piloted in Viet Nam in 2009 and is currently being rolled out in all provinces. It comprises a brief behavioural questionnaire added to the HIV sentinel surveillance surveys conducted routinely among people who inject drugs, female sex workers and men who have sex with men. Timely reporting of data from this system has resulted in improvements to HIV prevention efforts for most at-risk populations.

In this study, twenty-five yeast strains were isolated from soil samples collected in the gold mining ore in Gia Lai, Vietnam. Among them, one isolate named GL1 T could highly tolerate Cu 2+ up to 10 mM, and the isolates could also grow in a wide range of pH (3–7), and tem perature (10–40 ℃). Dried biomass of GL1 was able to remove Cu 2+ effectively up to 90.49% with a maximal biosorption capacity of 18.1 mg/g at pH 6, temperature 30 ℃, and incuba tion time 60 min. Sequence analysis of rDNA indicated this strain was closely related to Rhodotorula mucilaginosa but with 1.53 and 3.46% nucleotide differences in the D1/D2 domain of the 28S rRNA gene and the ITS1-5.8S rRNA gene-ITS2 region sequence, respect ively. Based on phylogenetic tree analysis and the biochemical characteristics, the strain appears to be a novel Rhodotorula species, and the name Rhodotorula aurum sp. nov. is pro posed. This study provides us with more information about heavy metal-tolerant yeasts and it may produce a new tool for environmental control and metal recovery operations.

Objective: To assess the acceptance of coronavirus disease (COVID-19) vaccine among healthcare workers at two general hospitals in Vietnam when it is available. Methods: A cross-sectional study was conducted using a convenience sampling from January to February 2021 among 410 healthcare workers at two general hospitals in Vietnam via a self-administered questionnaire. A multivariable regression analysis was performed to determine predictors of vaccine acceptance including the demographic factors, COVID-19 knowledge, and vaccine beliefs based on the domains of Health Belief Model. Results: Among 410 healthcare workers, 76.10% showed vaccination willingness. Predictors of acceptance were determined that the group reporting as 'vaccine acceptance' was more likely to be positive towards the perceived susceptibility and severity of COVID-19 (OR 2.45; 95% CI 1.48-4.06, P<0.05), perceived benefits of vaccination, and cues to action (OR 4.36; 95% CI 2.35-8.09, and OR 5.49; 95% CI 2.84-10.61, respectively, all P<0.001), but less likely to have the perceived barriers to vaccination (OR 0.19; 95% CI 0.09-0.38; P<0.001) compared with the no acceptance group. Besides, people who had a good knowledge regarding the severity of illness were 3.37 times more likely to have identified as vaccine acceptance (OR 3.37; 95% CI 1.04-10.86, P<0.05). The demographic factors were also associated with willingness to receive the vaccine, with participants who were staff and received COVID-19 information from relatives were less likely to accept the vaccine over those who were doctors and not receiving information from relatives (OR 0.36; 95% CI 0.13-0.96, and OR 0.37; 95% CI 0.17-0.78, respectively, all P<0.05). Conclusions: A rate of willingness to get vaccinated against COVID-19 was relatively high with discrepancies between occupation, receiving information from relatives, knowledge toward the severity of illness, and the elements of Health Belief Model. The findings will provide information for the management authorities to develop relevant interventions to promote COVID-19 vaccination uptake.