Background: Standard treatment for pleural infection includes of drainage and antibiotics. Chest tube drainage often fails if the fluid is loculated by fibrinous adhesions. Intrapleural fibrinolysis may facilitate pleural drainage. Objective: To evaluate the role of Streptokinase (STK) in the treatment of empyema and exudative pleural effusions. Subjects and method: A study included 34 patients (21 patients with exudative pleural effusions, 13 patients with empyema), aged 15-77 years. All patients received intrapleural STK daily with dose of 300.0000-500.000 UI for empyema and 300.000 UI for exudative pleural effusions. Response was assessed by clinical outcome, pleural fluid drainage, chest radiography, pleural ultrasound. Results: Mean pleural fluid drainage after STK instillation was higher in all patients. Pleural fluid drainage was 640 \xb1 494 ml before STK instillation and 823 \xb1 755 ml after STK instillation for empyema; 765 \xb1 691 ml before STK instillation and 1,033 \xb1 757 ml after STK instillation for exudative pleural effusions. The success rate of clinical outcome was 100%. Only 2 patients required decortications. Fever occurred in 3 patients (8.8%) and allergy in 1 patient (3%). Conclusions: Intrapleural STK was safe and effective in the treatment of empyema and exudative pleural effusions. STK prevents pleural adhesions and reduces the risks for surgery.
Streptokinase/ therapeutic use ; Empyema ; Pleural/therapy ; Pleural Effusion/ therapy

Introduction: Rabies is a serious problem in the area of public health in developing countries including Vietnam. The death rate is almost 100%, however rabies can be prevented and preventively treated by vaccine, or a combination between vaccine with rabies resistant serum. The production of Vero cell culture vaccine is becoming a common trend worldwide because of its effective protection and safety. There is a requirement for the domestic production of cell cultured rabies vaccine. \r\n', u'Objectives: To determine the adaptive ability of VNUCOVO - 32 rabies vaccine strain into Vero cell. \r\n', u'Subjects and Method: Rabies vaccine propagation strains the rat\u2019s kidney cells. VNUCOVO - 32 was cultured into Vero cell with different conditions such as pH, temperature, multiplicity of infection (MOl) and time of virus harvests to discover the optimal conditions for virus propagation. \r\n', u'Results: The optimal condition for VNUCOVO - 32 propagation into vero cell with MOl 0.3, pH 7.4 and temperature is 37\xb0C. The highest titer achieves 103,4FFLJ/ml. The best time for virus harvest is 12 - 13 days post inoculation. \r\n', u'Conclusion: VNUCOVO rabies vaccine strain can penetrate and propagate into vera cell. \r\n', u'
Rabies virus ; VNKONO \u2013 32 strain ; Vero cell

Background: Can Gio mangrove forest is bio-diversified area. There is few studies on medical arthropod in Can Gio mangrove forest until now. Objective: To study bio-diversified feature and identify species with disease transmitting role. Subject and Method: In 2007, medical arthropod surveys were conducted at 3 sites located in the natural conserve zone- Can Gio mangrove forest. A cross-sectional study was used. Results and Conclusions: A total of samples of 6178 individuals of medical arthropod belonging to 65 species have been collected, including 3 species of flea (Siphonaptera), 1 species of ticks (Ixodidae), 6 species of chiggers (Trombiculidae), 6 species of mites (Gamasoidea), 25 species of flies (Muscoidea) and 24 species of mosquitoes (Culicidae). They belong to 37 genus, 17 families, 3 orders (Siphonaptera, Acarina and Diptera), and 2 classes (Insecta and Arachnida). 20 species having epidemiological role were found in Can Gio mangrove forest. The rate of Anopheles epiroticus biting human at night indoor, outdoor and daytime indoor is rather high, especially at the end of dry season at centre of the forest.
Mangrove forest ; medical arthropod ; species ; genus

Background: Chronic obstructive pulmonary disease (COPD) remains a major public health problem. It is the fourth leading cause of chronic morbidity and mortality in the United States, and is projected to rank fifth in 2020 in burden of disease caused worldwide. Objective: To research the epidemiology of COPD in the population of Bac Giang city and finding out the risk factors of COPD. Subjects and method: Cross-sectional survey of general population sample of 2,104 men and women with the age \ufffd?0 years in 30 wards of 11 communes of Bac Giang city. Data on respiratory symptoms, diseases, and risk factors were collected. Lung function tests were performed with Spiroanalyzer snoo, Japan. Results and conclusions: The incidence of COPD was 2.3%; in men 3.0% and in women 1.7%. The incidence of simple chronic bronchitis was 6.4%. People who smoked had higher rate of COPD than the others (OR = 2.8). The incidence of smoking in COPD was 55.9%. The three most important risk factors of COPD was the age \ufffd?0; smoking >15 pack/year and medical history of asthma.
Pulmonary Disease ; Chronic Obstructive/ epidemiology

Backgrounds: Fecal occult blood testing (FOBT) is commonly used in colorectal cancer screening programs. Many studies have compared different FOBT methods, but the correlation between traditional red cell microscopy and FOBT remains unclear. Objectives: 1) To evaluate the rate of positive FOBT in patients with different disease groups; 2) To compare the sensitivity and specificity of red blood cells detection in fresh stool by microscopy technique and FOBT. Materials and methods: This was a cross-sectional study involving 120 patients from Hue University of Medicine and Pharmacy Hospital who requested a stool test from 4/2021 to 4/2022. Fresh stool samples were examined for the presence of red blood cells using traditional microscopy and FOBT technique. Results: The overall positivity rate of FOBT was 20%, and in the group of gastrointestinal diseases (n = 24), clinical anemia (n = 21), hepatobiliary diseases (n = 26) and other diseases (n = 49), it was 37.5%, 23.8%, 11.5% and 14.3%, respectively. In comparison with the FOBT technique, microscopic RBC detection had a sensitivity of 33.3% and a specificity of 100%. Conclusions: A high rate of fecal occult blood tests was observed in patients with gastrointestinal disorders. Microscopic erythrocyte detection has low sensitivity and many disadvantages compared to the rapid test. This rapid test should be widely used in clinical practice to aid in the diagnosis of gastrointestinal bleeding

Backgroud: The aim of this study is to update on antibiotic resistance of common pathogenical bacteria isolated in Hue University of Medicine and Pharmacy Hospital (Hue UMP Hospital). Methodology: Use of the agar disk diffusion method to test the susceptibility to antimicrobial agents of 3709 bacterial strains from infected patients hospitalized in Hue UMP Hospital in 2020 - 2022. Results: Among 3709 strains of pathogenical bacteria isolated, S.aureus was found with the rate of 29.9%, followed by E. coli (24.5%), Pseudomonas aeruginasa (17.8%), Enterococcus spp. (11.8%), Klebsiella spp (9.7%) and Acinetobacter spp (4.1%). The proportion of bacterial isolates has changed, but Staphylococcus aureus is still highest rate. S.aureus is resistant to many antibiotics, but MRSA strains have decreased significantly, from 73.3% in 2020 to 62.5% in 2022. Pseudomonas aeruginosa was resistant to some of the group A recommended antibiotics such as ceftazidime, piperacillin-tazobactam with the rate of 56.6% and 48.7%. The percentage of E. coli with ESBL strains (+) was at 28.2% - 30.3%. Enterococus spp strains are still sensitive to vancomycin (83.1% - 91.9%). The rate of Klebsiella ESBL (+) is only 6.9% to 8.2%. The strains of Acinetobacter spp were highly resistant to Piperacillin (100%) and Ceftriaxone (96.5%) but they are still sensitive to imipenems 70 - 71%, highly sensitive to Doxycillin (95.2%) and Cefotaxime (88.4%). Conclusion: Many bacterial strains are resistant to many commonly antibiotics. Providing timely, regular, and effective management of antibiotic resistance patterns for common pathogenic bacteria in hospitals, will help reduce the risk of bacterial resistance.