1.Anti-Inflammatory Effect of Theophylline in Asthma Management.
Pediatric Allergy and Respiratory Disease 2000;10(2):112-118
No abstract available.
Asthma*
;
Theophylline*
2.The Use of Continuous Theophylline Infusion in Pediatrc Severe Bronchial Asthma.
Jae Wook LEE ; Hyang Suk HYUN ; Byung Hak LIM ; Im Ju KANG
Journal of the Korean Pediatric Society 1989;32(5):678-686
No abstract available.
Asthma*
;
Theophylline*
3.Pilot study on manufacture of theophylline microcapsule by isolation method of congelation - phase
Pharmaceutical Journal 1999;282(10):23-24
Preparation of theophylline microcapsule by the coacervation - phase seperation method. Theophylline microcapsule has been prepared by coacervation - phase seperation, using ethyl cellulose as the coating material. Ethyl cellulose sustanined significally the release of theophylline from microcapsule. Microcapsule has been used for preparation of theophylline sustained - release tablet.
Theophylline
;
Capsules
4.Study on preparation of theophylline microcapsule by spray-drying method
Pharmaceutical Journal 1999;282(10):20-21
The theophylline microcapsule has been prepared by spray-drying technique, using ethyl cellulose as the coating material. Ethyl cellulose sustained significally the release of theophylline from microcapsule has been used for preparation of theophylline sustained-released tablet.
Theophylline
;
Capsules
5.The effect of prednisolone on serum theophylline concentration in Korean pediatric patients with asthma.
Hyea Kyeong CHUNG ; Hee Jung LEE ; Un Ki YOUN ; Ji Sub OH
Pediatric Allergy and Respiratory Disease 1993;3(1):50-58
No abstract available.
Asthma*
;
Humans
;
Prednisolone*
;
Theophylline*
6.Evaluation of Vitros 950 for Quantitative Analysis of Digoxin and Theophylline.
Jong Phil KIM ; Min KIM ; Myoung YUN ; Chang Jae LEE ; Jong Hee SHIN ; Soon Pal SUH ; Dong Wook RYANG
Korean Journal of Clinical Pathology 1999;19(4):409-413
BACKGROUND: We evaluated the Vitros 950 (Johnson & Johnson Clinical Diagnostics, Inc., NY, USA) in the measurement of digoxin and theophylline levels and compared its results to those of the TDxFLx II (Abbott Laboratories, IL, USA) used for therapeutic drug monitoring (TDM) world-widely in order to assess the utility of the Vitros 950 as a TDM instrument. METHODS: From June 1997 to August 1997, 125 and 135 candidates for TDM were randomly chosen to measure digoxin and theophylline, respectively, using the Vitros 950 and TDxFLx II. The relationship between its results and those of TDxFLx II were determined. The within-run and between-run precisions of the Vitros 950 were determined using two controls (Vitros Performance Verifier I and II; J & J Clinical Diagnostics, Inc., NY, USA). The high-concentration control (Vitros Performance Verifier II) was diluted in Vitros 7% BSA to 5 dilutions. And linearity for quantitative analysis of digoxin and theophylline were determined. RESULTS: The coefficients of variation (CV) for the within-run of the Vitro 950 were 0.8% - 4.4%. And the CV for between-run precision of the Vitro 950 were 1.7% - 12.3%. The linearity of digoxin and theophylline were relatively good. The correlations (r) of digoxin and theophylline levels with those determined by the Abbott TDxFLx II were 0.95 and 0.93, respectively (P <0.001). CONCLUSIONS: The recently developed dry slide method of the Vitros 950 proves to good precision and linearity for quantitative analysis of digoxin and theophylline. Its results correlate well with those of the TDxFLx II. The Vitros 950 does not require an elaborate preparatory protocol for the sample, and is easy to use and maintain.So it is considered a highly feasible instrument for stat test.
Digoxin*
;
Drug Monitoring
;
Theophylline*
7.Chemical experimental tests of theophylline tablets with release action (Theo KD) manufactured by Hanoi Pharmacy College
Pharmaceutical Journal 2003;331(11):23-25
Theophylline tablets with release action (Theo KD) was tested in dosage 100mg x 2 tablets a time each 12 hours for asthma patients, and was compared to 100mg THEOSTAT tablet with release action of Laboratoiries INAVA (France). Results: Theo KD was suitable in the treatment of 2 0r 3 degree asthma. ADRs were minor and temporary. No one stopped treatment due to ADRs
Theophylline
;
Tablets
;
Chemistry
8.Comparison between adverse effects of low and usual doses of intravenous aminophylline.
Bok Ki KIM ; Dae Hyun LIM ; So Hyun AHN ; Jong Hoon KWAK ; Jeong Hee KIM ; Byong Kwan SON
Korean Journal of Pediatrics 2009;52(4):441-445
PURPOSE: Some patients develop side effects from theophylline even at low serum concentrations. We designed a prospective study to evaluate the side effects of theophylline. METHODS: A Prospective, controlled trial study was conducted. The low-dose group received an intravenous continuous aminophylline dose of 5 mg/kg/day on the first day and subsequently 10 mg/kg/day on the following two days. The usual-dose group received 10 mg/kg/day for three days and the control group received normal saline for three days. Heart rate, respiratory rate, serum concentration of theophylline, and four adverse events (irritability, sleep disturbance, jitter, and vomiting) were checked at the time of admission and at 2, 12, 24, 48, and 72 h after the start of aminophylline infusions. RESULTS: Nine patients out of 37 in the low-dose group and six of 21 in the usual-dose group dropped out because of uncontrolled irritability. The serum concentrations of theophylline in dropouts (3.68+/-1.93 ig/mL) and participants (4.47+/-2.45 ig/mL) were not significantly different. Irritability was a more frequent side effect in the usual-dose group at 12 h, but there was no difference between the low-dose and usual-dose groups in terms of vomiting, sleep disturbance, and jitter. Most of the severe adverse effects were observed in children below two years of age. CONCLUSION: Some patients dropped out regardless of the initiating aminophylline dose, especially patients under the age of two years.
Aminophylline
;
Asthma
;
Child
;
Heart Rate
;
Humans
;
Patient Dropouts
;
Prospective Studies
;
Respiratory Rate
;
Theophylline
;
Vomiting
9.Effects of enoxacin and ciprofloxacin on the theophylline metabolism in humans.
Soo Jeon CHOI ; Bong Choon LEE ; Dong Soon KIM
Tuberculosis and Respiratory Diseases 1991;38(4):372-378
No abstract available.
Ciprofloxacin*
;
Enoxacin*
;
Humans*
;
Metabolism*
;
Theophylline*
10.Clinical tests of theophylline tablets with release effect prepared by the Hanoi Pharmaceutical college
Pharmaceutical Journal 2003;9(6):26-29
The study conducted on bronchial asthmatic patients treated at Allergic Clinic in Bach Mai Hospital. The patients treated by theophylline pill acting within 12 hours, manufactured by Hanoi College of Pharmacy combined with Central Pharmaceutical Factory No. 2, used single-blind, controlled method. The patients used 200mg dose, twice in day (8 a.m and 8 p.m), separated from each other 12 hours. Results: The change of respiratory functions are good, both groups are more than 15 percentage
Theophylline
;
Clinical Chemistry Tests
;
Tablets