Intra-cranial hemorrage is a serious condition in infants can result in significant morbidity and mortality in developing countries. 680 infants with intracranial haemorrhage have symptoms for 30-60 days (86.2%). Sex ratio between boys and girls was 3/1. The laboratory findings as followed: prolongation of PT, APTT (94,7%), diminution of factors II,VII,IX in 80% of cases. Clinical manifestations are acute anemia (99.1%), distubance of consiousness (100%);100% have some kind of seizures; 91% in bulging of the anterior fontanel. Subarachnoid hemorrhage was major condition in 90.1% of patients, but allways combined with other lesions. The mortality was 14.7% and survived children had severe psycho-neurological sequelae. Intra-cranial hemorrhagic disease in infants has the characteristics of vitamin K deficiency. The haemorrhagic lesions are diverse and complex. Disease caused high mortality as well as high sequella rates.
Intracranial Hemorrhages , Infant, Epidemiologic Studies, Laboratories, Vietnam

Introduction: This action research aimed to make a context-specific and gender-sensitive interventions. Intervention activities was participatory to decrease the barriers to the use of maternal care and family planning (MCFP) services by the disadvantaged Kinh people and Catu ethnic minority people in the mountainous area of Nam Dong District in Central Vietnam. Intervention also aimed to improve communal MCFP services prioritized to training effective communication skills for communal health centers' staff and village health workers. Methods: 2 surveys were conducted before and after intervention among 7 poor communes using a random sample of total 840 mothers with at least one child under the age of 5 years. These data were supplemented by interviews with key informants, focus group discussions and observations. Statistical tests and measurement of effective index (EI) were used in data analysis. Results: - Women having ANC and delivery at local MCFP service were increasing 97.6% and 50% in year 2005 as compared with 86.9% and 31% respectively in year 2003. Midwives paid much attention to non-verbal communication as well as to counseling using demonstrative pictures. - There were a clear evidence of significantly increasing the mother's knowledge of MCFP such as local MCFP service availability, benefit of ANC (p<0.001) supported by performing many different communication channels (safe motherhood talks, village safe motherhood clubs, mass media of video-cassette using Catu speaking language, safe motherhood integration in traditional festival, campaign etc. - There was only statistically significant increase of inject able contraceptive ( EI=58.14%). The number of mothers having ANC>=3 times was significantly increasing (EI=11.98%, p<0.01). - The percentage of mothers who delivered at home was slow down to 19.4% as compared with before intervention was 45.2% respectively (EI= 64.20%, p<0.001) Conclusion: Intervention model was considerably successful in using context-specific and gender sensitive approaches. It contributed to meeting an urgent need for the MCFP services to build both clinical capacity and health promotion activities in a way that is gender sensitive, knowledge on of traditional practices and accessible by both illiterate and minority language speaking people.
Maternal Health Services ; Family Planning Services ; Maternal Behavior

The morbidity rate of the cerebro- meningeal hemorrhage is high. From 1991 to 1998, the Institute of Pediatry, hospital Saint Paul and Bach Mai hospital admitted 1,325 pediatric patients with this disease in which 793 patients during 1991-1995 and 532 patients during 1996-1998. The morbidity rate in Hanoi and Ha Tay with population of 2 million was 110.5-124.15/1000.000 infant. The mortality rate was 17.2% of morbidity number. The highest morbidity occurred in the months of 9-12. Infant with 1-2 months accounted for 88.5% morbidity. Disease acquired infant with the normal history account for 91.5. The birth weight over 2.5 kg in the disease acquired infant account for 90.4%. The morbidity rate in female was higher 3 times than this in male. The infant received breast milk account for 95.7%.
Cerebral Hemorrhage ; Infant

During 2 years from 1998 to 1999, 76 pediatric patients underwent brain CT imaging at the Pediatric Institute. Patients aged 30-60 days and admitted with severe anemia (average of Hb 6.5+/-1.5g%). Some features of cerebral-meningeal damage in patients with cerebral-meningeal hemorrhage were showed. The most common types are subarachnoid hemorrhage (91.9%), subdural hemorrhage (74.3%), brain tissue hemorrhage (52.7%), cerebral ventricular enlargment (35.1%), lateral cerebral ventricular compression (72.4%), midle-way displacement (82.6%), cerebral oedema (96.5%). Cerebral- meningeal damage combinations included submeningeal hemorrhage alone (15.8%), subduralmeningeal hemorrhage 35.5%, submeningeal-cerebral tissue hemorrhage (48.7%).
Cerebral Hemorrhage ; infant

Background: In Vietnam,every day on average at least 16 children died and more than 82 children were seriously injured by traffic accidents. Objectives: The study on epidemiological characteristics of traffic injuries in children.Subjects and method:A retrospective study of 539 children hospitalizedas a results of traffic injuries in National Hospital of Pediatrics, from january 2002 to december 2005. Results: Traffic injury hospitalization incidence rate is 0,42% (539/ 127706). Male/female was 1,46/1. Peak incidence occurs at ages 5 to 9 years. Rural children/ city children was 2,06/1. Crashes happened in october with highest frequency 12,8%, and weekend (34,8%). Motor vehicle crashes was 426 (79%). Motorcycle caused 70,4% crashes, and automobile 9,2%. 59% victims are child pedestrians.Conclusion: The traffic injury occurs commonly in children, especially in group 5-9 age. Motorcycle was the most principal vehicles occupant injuries.
Accidents ; Traffic ; Wounds and Injuries/ epidemiology ; Child ;

Background: Intracranial hemorrhage (lCH) is a common disease with high rate of mortality and neurological sequel. Objectives:to estimate preventive effectiveness of intracranial hemorrhage by vitamin K1 and K3 for newborns just after birth". Subjects and methods: An epidemiological, randomized control study with intervention was conducted. The study included all children under 3 months with and without ICH during period 1/1/2000 -30/6/2004 living in Hatay province. Among them all the newborns during period 1/6/2002 - 30/6/2004 were injected either 1 mg vitamin K1 or K3. Results: Children injected with vitamin K in the intervention period were followed up in three months and evaluated by a united process. Effects of intervention were calculated by preventive value. 62.057/82069 newborns were injected vitamin K1 or Vitamin K3 (25.725 newborns were injected Vitamin K1; 36.332 newborns were injected vitamin K3). Single dose 1M reduced the rate of ICH in infants: The morbidity changed from 3.3\ufffd?to 0.82\ufffd? the prevention value was 96%. There were no complications and side effects of vitamin K injections reported. Conclusions: Injection of vitamin K1 and K3 have similar preventive effectiveness. Vitamin K injection 1M with recommended dose was safe for newborns.\r\n', u' \r\n', u'\r\n', u'
Intracranial Hemorrhages ; Vitamin K Deficiency

Background: Idiopathic or Immune Thrombocytopenic Pupura (ITP) is a common disease in Vietnamese children. This is a hemostatic disorder disease diagnosed by clinical symptoms combining with tests of platelet quantity in peripheral blood and other tests. Objectives: to study epidemiology, clinical, para-clinical characteristics and their relations in ITP disease. Subjects and methods: This was a prospective and retrospective study. The study included 579 pediatric patients from 3 months to 16 ages who were diagnosed and treated ITP disease in National Pediatric Hospital from 1/1/2003 to 12/31/2004. Results: Data were analyzed, including 191 infants from >3-<12 months (33.0%), 293 children from 1 - 10 ages (50.6%), 95 children >10-<16 ages (16.4%). The male/female ratio was highest in infants and decreased with age (P < 0.001). The disease occurred more in September, October and November with advantage factor being acute respiratory infection before 2 to 3 weeks. Subcutaneous hemorrhage ratio was highest with 557 cases (96.2%), intracranial hemorrhage happened in 7 cases (1.7%). There were differences among age groups about hemorrhage situation. Anemia level did not corresponding with the decrease of the platelet count. Conclusion: Characteristics of ITP depend on the number of platelet and age. \r\n', u'\r\n', u'\r\n', u'
Purpura ; Thrombocytopenic ; Idiopathic/ epidemiology

Background: Intracranial haemorrhage is a common emergency with high mortality and neurological sequelae Objectives: The aim of study were to estimate the distribution of intracranial haemorrhage between the groups of age in children and the relationship of epidemiologic characteristics to the etiology.Subjects and method: We gathered prospectively data on 621 children (0-15 ans of age) with intracranial haemorrhage in 3 years (2000, 2001, 2002) hospital records in the National Hospital Pediatrics. Results: There are annual 200 patients (0-15 ans of age) of administration. 1) Neonatal infants consisted of 97 (15,6%) patients and 35 (36,1%) of death. Some of epidemiologic characteristics associated with the etiology were premature, asphyxial over 3500 gram birth weight, interventional birth infants and infants with congenital and acquis coagulation disorders. 2) Breastfed infants consisted of 469 (75,5%) patients of administration and 52 (11,1%) of death. Infants at 29 days to 3 months of age were the most frequence (92,3%). The etiology was associated with coagulation disorders (82,9%), cholestasis (6,2%). 3)Children (1-15ans) consisted of 55 (8,9%) and 7,3% of death, specially adolescent children (7-15ans) occupied 86,3% patients in this group. The etiology could be cerebral vasculare malfmation. Conclusion: There are different distribution of administration, mortality, etiology between neonate, breastfed infants, children (1-15 ans of age)
Intracranial Hemorrhages/ epidemiology ; Child ; Infant ; Infant ; Newborn ;

Background: The intracranial hemorrhage (lCH) in infant due to vitamin K deficiency were been informed a lot at all over the world since the year of 80's. In Viet Nam, in recent years, this disease still most occurs which account for 110-130 children/100000 alive infant. The intracranial hemorrhage (lCH) in infant causes severe neurological, psychiatric sequelae. Objectives: This study aims to analyze the characteristics of epilepsy, changing of electroencephalogram and lesions of brain after intracranial hemorrhage in infant. Subjects and method:A descriptive, cross sectional study was conducted on 97 infant patients with the age ranged from 8 days to 3 months years old whom treated in National Hospital for Peadiatric. Results: Epilepsy was common (45.3%), with generalized seizures in 24.7% , partial seizures in 20.6%. The main intracranial lesions were cerebral cyst and atrophy in right or left hemisphere or both sides. Electroencephalic activity was found impaired in most of patients: Disorder of background waves in 19.6 %, low localized waves in 31%, proxystic ativity with spike in 45.3% and decrease in electroencephalographic amplitude in cystic areas. Conclusion: The epilepsy, abnormal electroencephalographic activities, severe lesions of brain were common after intracranial hemorrhage in infant.
Intracranial Hemorrhages/ diagnosis ; pathology ; therapy ; Infant

Background: Dementia is a common pathological condition that affects older people. Most causes of dementia are Alzheimer\u2019s disease and vascular dementia. Diagnosing these conditions mostly relied on clinical patterns, but some biomarkers have been mentioned as the indicators of this condition. Objectives: 1) To evaluate the alteration of some biomarkers in cerebrospinal fluid (CSF) samples from Alzheimer\u2019s patients. 2) To compare the concentration of biomarkers in CSF samples from patients with vascular dementia and Alzheimer\u2019s disease. Subjects and method: Case group involved 41 patients who were diagnosed as AD and vascular dementia based on DSM-IV criteria. 31 matched healthy people were included in control group. All subjects were given neuro-psychological tests and thorough clinical examination. Brain CT scan and MRI were done for both groups. CSF samples were taken from patients in the study group to measure levels of some biomarkers. Results. The levels of total taurine (T-tau) and phosphorylated taurine (P-tau) 181 proteins are higher in the dementia group. The concentration of Abeta-42 is significantly different between case and control groups, but similar between vascular dementia and Alzheimer\u2019s disease patients. Conclusion: Changes in biomarkers are valuable in different diagnosis of Alzheimer\u2019s disease and other types of dementia. However, findings of CSF studies have to be considered with findings from imaging studies and clinical examination.
Biomarker ; Dementia ; Alzheimer\u2019s disease