Study on the peroxidation of membrane lipid and the change of some anti-oxidant enzymes during the storage of erythrocytes by additive system. The invitro study was conducted with two additive systems: one is the AS-T which is the first preparation in VN and the other is the preparation of Terumo, a leading company of the world on the blood preparations. The results demonstrate that the two systems are equally in the anti-peroxidation activation of membrance lipid. The ability to maintain enzyme activation of Superoxyd dismutase (SOD) and Gluathion peroxidase (GCH-Px) of erythrocytes during of storage process (from ) to 35 days), the erythrocyte mass which is preserved by AST solution abilize activity of SOD and GSH-Px better than by Terumo solution, with this result os signficant slower increasing of MDA concentration at the end of storage
Lipids ; Intracellular Membranes ; Erythrocytes

After conserving by AS-T solution for 42 days, 95% of erythrocytes were remained in good condition and the HGB and HCT indices were still in normal range. Comparison with another erythrocyte conserving solution made by Terumo (Japan) showed that the erythrocytes conserved by AS-T solution were not significant different not only at the beginning but also by 42 days of experiment.
Erythrocytes ; Research ; Solutions ; Pharmaceutical Preparations

To compare the influence of the Bach Mai prepared AS-T preserving solution and Japanese Turumo firm prepared preserving solution in a same condition on the blood of 5 healthy persons of B group blood, who did not donate the blood. AS-T solution had stabilized and maintained the red blood cells, pH higher than 7 through a storage duration of 42 days. AS-T solution had maintained 2.3-DPG concentration in a level higher significantly in comparing with Terumo solution at the terminal points of the storage time PK and G6PD activities of the red blood cells mass preserved by AS-T solution as well as Terumo solution had decreased progressively in the duration of storage.
Erythrocytes ; 2,3-Diphosphoglycerate ; Pyruvate Kinase

Adenin made a comfortable impact on erythrocytes during preservation, both on the ability to maintain the number of red blood cell (RBC), to stabilize the pH and osmotic pressure of erythrocytes. The presence of adenin in the component of the solution that preserved erythrocytes with the most suitable concentration was 0.04/100ml. At the 28th of preservation, RBC of all studied formulas suddenly decreased. Adenin didn't maintain over 98% RBC, stabilized the pH of erythrocytes on the level 7 at the 42nd days during preservation
Adenine ; Erythrocytes ; Blood

Objectives: The coronavirus disease 2019 (COVID-19) pandemic has increased the workload of healthcare workers (HCWs), impacting their health. This study aimed to assess sleep quality using the Pittsburgh Sleep Quality Index (PSQI) and identify factors associated with poor sleep among HCWs in Vietnam during the COVID-19 pandemic. Methods: In this cross-sectional study, 1000 frontline HCWs were recruited from various healthcare facilities in Vietnam between October 2021 and November 2021. Data were collected using a 3-part self-administered questionnaire, which covered demographics, sleep quality, and factors related to poor sleep. Poor sleep quality was defined as a total PSQI score of 5 or higher. Results: Participants’ mean age was 33.20±6.81 years (range, 20.0-61.0), and 63.0% were women. The median work experience was 8.54±6.30 years. Approximately 6.3% had chronic comorbidities, such as hypertension and diabetes mellitus. About 59.5% were directly responsible for patient care and treatment, while 7.1% worked in tracing and sampling. A total of 73.8% reported poor sleep quality. Multivariate logistic regression revealed significant associations between poor sleep quality and the presence of chronic comorbidities (odds ratio [OR], 2.34; 95% confidence interval [CI], 1.17 to 5.24), being a frontline HCW directly involved in patient care and treatment (OR, 1.59; 95% CI, 1.16 to 2.16), increased working hours (OR, 1.84; 95% CI,1.37 to 2.48), and a higher frequency of encountering critically ill and dying patients (OR, 1.42; 95% CI, 1.03 to 1.95). Conclusions The high prevalence of poor sleep among HCWs in Vietnam during the COVID-19 pandemic was similar to that in other countries. Working conditions should be adjusted to improve sleep quality among this population.

Objectives: This study was conducted to measure financial toxicity (FT) among patients with cancer in Vietnam using the COmprehensive Score for financial Toxicity (COST) and to describe the cost management strategies employed by these patients. Methods: This comprehensive cross-sectional study enrolled 634 patients from 2 specialized oncology hospitals in Vietnam. Using COST cut-off scores, FT was classified as none/mild (≥26), moderate (14-25), or severe (≤13). Cost management strategies, or coping mechanisms, were classified into 4 groups: lifestyle changes, financial resource strategies, treatment modifications, and support seeking. Results: The prevalence of FT was 91.8%, with 51.7% of participants demonstrating severe and 40.1% exhibiting moderate FT. Severe FT was significantly associated with female, low education level, unstable employment, low household economic status, and advanced cancer stage. The most common coping strategies were as follows: among lifestyle changes, reducing spending on basic items and leisure activities (78.7%) and cutting back on essential household expenses (66.4%); among financial resource strategies, borrowing money from relatives or friends (49.1%) and withdrawing funds from retirement or savings accounts (34.1%); within treatment modifications, switching treatment facilities or doctors due to cost concerns (9.3%); and within support seeking, obtaining help from welfare or community organizations (18.8%). All strategies were significantly more likely to be used by patients with severe FT. Conclusions FT was highly prevalent among patients with cancer. Most patients relied on lifestyle adjustments and coping strategies, underscoring the need for improved financial support systems to alleviate the economic burden associated with cancer care.