An HPLC method was proposed to determine simultaneously metronidazole and clotrimazole in tablets with the chromatographic conditions as follow: Column: Lichrosorb RP 8 (250x4mm; 5Mm). UV detector at 215 nm. Mobile phase: Methanol: dipotasium hydrogen phosphate 0.025M (2:1). Flow rate: 1ml/min. The experimental results proved that the proposed HPLC method had a high accuracy 0.49 - 1.53%, maybe applied regularly in experimental centers
Vaginal Diseases ; Chromatography, High Pressure Liquid ; Metronidazole ; Clotrimazole

The study built process of extraction vitamin D3 in Patarvit syrup by SPE technique with mean extract performance as 98.2%. Chromatography was built to quantity vitamin D3 as following: Lichrosorb RP 18 column (250 X 4 mm, 5 and 10µm ); Detector UV: 265 nm; movement phase: Methanol-ethyl acetate - water (90:7:3); stream speed: 1.5ml/minute. Injection volume: 20µl. The method had a high accuracy (E% = 1.18%). Percentage of withdrawal was 96.8% with E% = 0.71%; the limit of detection (LOD) was 5.79IU/ml, the limit of quantitative (LOQ) was 19.3IU/ml
Vitamin D ; Pharmaceutical Preparations

Investigating UV absorption spectrum of paracetamol (5µg/ml, solvent HCl 0.1N) and quinine sulfate (4µg/ml, solvent HCl 0.1N) of antigrip F tablet within the range 200nm to 400nm with HCl 0.1N solution as blank sample showed that: At wavelength 340nm, paracetamol did not absorb, which was not influence to analyze method. The comparison between MCA and normal spectrum method showed that the difference was not statistical significantly α = 0.05 (compared 2 variances, F test, mean values). The advantages of MCA method are rapid, accurate, and solvent-saving. For mixture containing two above ingredients, the content of each formulation’s ingredient can be simultaneous and accurate assayed by measuring absorption level of 4 wavelengths on normal spectrum machine
Spectrophotometry ; Acetaminophen ; Quinine

The concurrent quantification of this 4 factors mixed tablet using HPLC resulted in the establish of a quantifying procedure with high precision (0,87- 1,91%) good accuracy (get backing to 98,8%- 99,5%). Lineal degree was investigated in a large range of concentration and could be applied on diverse mixed tablet samples containing 2-4 active substances of various formulations. The technique gave sombrous advantages, simple, quick, saving the solvant
Dextromethorphan ; Chlorpheniramine ; Phenylpropanolamine

Full Spectrum Quantification technique gained fast, accurate results without extraction. This conforms to analysis of drug samples on the market. Results proved the method was accurate and has the acceptable reproducibility
Acetaminophen ; Ibuprofen ; Tablets

An HPLC method for determination of paracetamol and quinin sulfat in Antigrip F tablets is introduced. The chromatographic conditions are follows: Column: Lichrosorb RP18(250 4mm; 5mm); Mobile phase:1.1 g sodium heptanesufonate in L of a mixture of methanol-4% acetic acid-diethylamine(650:350:1);Flow rate:1ml/min;UV detector at 235nm. Experimental results showed that the method is accurate and precise(e=1.16%-1.88%;recoveries 99%-93%)
Acetaminophen ; Quinine ; Chromatography, High Pressure Liquid ; tablets