In order to investigate the effects of deep sea water bathing on relaxation and daylight sleep in night shift workers, electroencephalography, circulatory and cardiac autonomic functionings, visual evoked potential, biochemical markers in urine and saliva, core body temperature, sleep questionnaires, and mood state questionnaires were evaluated in nine subjects to compare with other three kinds of bathing including sham (no water), tap water and surface sea water. Deep sea water bathing showed better subjective sleep latency for sleep questionnaire (p<0.1) and significantly better vigor status for mood questionnaire (p<0.01) between four kinds of bathing. With regard to the objective data, despite the biggest increase in temperature of eardrum in deep sea water bathing, the highest sleep efficiency and the shortest wake period during sleep in electroencephalography did not reach to the significant level.

In recent times, an ingestible capsule sensor for the measurement of core body temperature has become available. This equipment was used to measure the relationship between core body temperature and daily living activities such as eating, exercise and bathing etc.
The main findings were as followings:
1. With respect to daily living activities, the core body temperature during bathing showed higher values in comparison with eating and light-grade exercise etc.
2. For the same-grade of exercise (HRmax60%) either in an environmentally controlled room at either constant temperature (25°C) and humidity (50%) or in water (36°C; 50%humidity), the core body temperature showed almost identical changes for peak value and the rise and fall ever time.
3. Atypical work at midnight was associated with a continuous decrease in core body temperature.
4. Atypical sleep in the daytime was associated with a continuous decrease in core body temperature.
5. For daily living activities inducing an increase in core body temperature, the correlation coefficient between core body temperature and heart beats/min was 0.87 (p<0.01).

Patients with fatty liver diagnosed by computed tomography (CT) were studied clinically. Diagnostic criteria of fatty liver by CT was that the ratio of CT value of the liver to that of the spleen was less than 0.90. In cases of fatty liver, hepatic volume was significantly more increased (p<0.01) than normal controls, but volume of the spleen was not more increased. Fatty liver was diagnosed by CT in thirty eight cases. These cases were divided into four groups according to causes of fatty liver.The first was obesity group (fifteen cases), the second was alcohol group (fourteen cases), the third was DM group (four cases) and the fourth was group of unknown origin (five cases). Values of GOT/GPT (OP ratio), γ-GTP, CHE, LAP and ALB were significantly different (p<0.01) between obesity and alcohol group. Many cases of obesity group showed hypercholinesterasemia, but in many cases of alcohol group values of cholinesterase were lower than normal range.

Liver function influenced by drinking were studied in cases of a thorough physical examination. Objects of our study were 172 cases who entered in our clinic during past two years. 172 cases were divided into three groups. 1st group was 70 cases who had drunk less than 20 grams of ethyl alcohol a day, 2nd group was 49 cases who had drunk 20 grams a day and 3rd group was 53 cases who had drunk 40 grams a day.
GOT, GOT/GPT, γ-GTP, CHE and LAP were changed significantly with the increase of drinking as a result of study of these three groups. Especially it was thought that GOT/GPT, γ-GTP and LAP reflected most sharply the grade of alcoholic liver injury.

In order to investigate effects of deep sea water bathing on psycho-physiological status, body temperature, circulatory and autonomic nervous system functions, and questionnaires on refreshment and sleep were evaluated in comparison with other 3 kinds of bathing including sham (no water), surface sea water and tap water. The skin temperatures of both tights and lower back were significantly higher for only deep sea water bathing compared with the sham bathing. It was also the case for tympanic temperature. Concerning circularly and autonomic nervous functions there were no significant difference between 4 kinds of bathing. For refreshment and sleep quality both sea water bathing showed higher scores, but not consistently significant differences. However, when taking any kind of bath shorter sleep latency was related to higher cardiac parasympathetic activity during sleep.