Study on 26 degree 2 and 3 asthma patients, treated terbutalin inhalation at Cochin Hospital, Paris from November 2001 to August 2002. The results showed that: blood oxygen deficient status in asthma episode (PaO2: 73mmHg±2.6) account for 54%. Arteries oxygen saturated decreasing status before terbutalin inhalation account for 80%. The blood gaz improvement after beta 2 stimulative drug inhalation expressed parameters: increasing arterial blood oxygen pressure, decreasing PaCO2 pressures, increasing arterial blood oxygen saturation. Terbutalin is a strongly bronchial stretch drug, gaining treatment results in several minutes, improving ventilation thoughout the changes of blood gaz
Asthma ; Therapeutics ; Terbutaline

A controlled study was carried out in 50 patients with perennial bronchial asthma to assess the efficacy and safety of budesonide turbuhaler. Subjects have suffered from cough, wheezing, dyspnea and chest tightness and showed either 15% of reversibility in FEV after bronchodilator inhalation or airway hyperresponsiveness to methacholine(PC20 < or = 25mg/ml.) Patients were randomized to treatment with budesonide turbuhaler or terbutaline turbuhaler for 8 weeks after 2 weeks of run-in period. Budesonide turbuhaler was effective for cough, wheezing, dyspnea and chest tightness. It improved peak expiratory flow rate and FEV1. Budesonide turbuhaler was tolerated well and the laboratory tests showed no abnormality. It is suggested that budesonide turbuhaler is effective and safe in the management of bronchial asthma.
Asthma ; Budesonide* ; Cough ; Dyspnea ; Humans ; Inhalation ; Peak Expiratory Flow Rate ; Respiratory Sounds ; Terbutaline ; Thorax

PURPOSE: We aim to compare the effectiveness and safety of fluticasone propionate (Flt) plus tulobuterol (Hk) versus high-dose Flt alone in controlling asthma in children. METHODS: Fifty three children aged 4 to 8 years, who were diagnosed with mild persistent asthma and underwent maintenance therapy with a low dose of inhaled corticosteroid (Flt) of 50-100 microgram/day were randomized to receive Flt plus Hk (Hokunalin(R) patch 1 mg, Abbott Japan, Tokyo, Japan), or Flt alone at twice the dosage. Patients underwent new treatment for 4 weeks. Asthma symptom scores, mean changes in morning and evening peak expiratory flow (PEF), the frequency of night awakenings, the use of reliever medication, caregiver's overall satisfaction and safety were evaluated and compared in each group. And they were followed-up again 4 week after treatment course for the evaluation of treatment-emergent adverse event (TEAE). RESULTS: No significant difference was found between the groups in terms of mean changes in the morning and evening PEF, the frequency of night awakening, the use of rescue medication and caregiver's overall satisfaction (P=0.83, P=0.83, P=0.17, P=0.32 and P=0.63). Furthermore, no statistically significant difference was observed between 2 groups in the incidence of any TEAE (P=1.00). CONCLUSION: This study demonstrated that a combination of Flt and Hk was as effective as a high-dose Flt therapy in the management of mild persistent asthma in children. The results of this study suggest that tulobuterol add-on therapy can be considered as a reasonable substitute to an increase in the dosage of steroid in the patients with steroid-phobia and it might be used to reduce the risk of high dose steroid therapy.
Aged ; Androstadienes ; Asthma ; Child ; Diethylpropion ; Humans ; Incidence ; Japan ; Terbutaline ; Tokyo ; Fluticasone

The mechanism of development of pulmonary edema associated with -sympathomimetic agent is still not fully understood. 2-sympathomimetic drugs such as ritodrine, terbutaline, and fenoterol are widely used for the treatment of premature uterine contraction. We describe a case of pulmonary edema that occurred suddenly during Cesarean section in a previously healthy parturient, associated with ritodrine pretreatment for 5 days in an attempt to arrest preterm labor. Pulmonary edema was completely treated with mechanical ventilation and diuretic therapy.
Cesarean Section* ; Female ; Fenoterol ; Humans ; Obstetric Labor, Premature ; Pregnancy ; Pulmonary Edema* ; Respiration, Artificial ; Ritodrine* ; Terbutaline ; Uterine Contraction

Administration, Inhalation ; Adrenergic beta-Agonists ; adverse effects ; Child ; Extremities ; Humans ; Male ; Paralysis ; chemically induced ; Terbutaline ; administration & dosage ; adverse effects

BACKGROUND: Priapism is a rare complication seen in one to five percent of adult leukemic patients. The word 'Priapism' is related to Priapus, the Greek and Roman God of procreation whose symbol was an erect phallus.

CLINICAL PRESENTATION: The patient is a 22-year-old male with no known co-morbidities presenting with one month intermittent, unstimulated, painful penile erection with no other associated symptoms which resolves spontaneously, until nine hours prior to admission when symptoms recurred and persisted. Patient had no history of trauma and no drug intake.

PHYSICAL FINDINGS: Patient was awake, in pain and tachycardic. There was note of pallor and splenomegaly. The penis was erect, firm, swollen and tender with superficial venous engorgement. The rest of the physical examination was unremarkable.

LABORATORY WORK UP: Complete blood count showed anemia and leukocystosis. Peripheral blood smear revealed markedly increased white blood cells with predominance of mature and immature cells belonging to granulocytic series. There was splenomegaly on ultrasound. Genetic testing showed an abnormal male karyotype of 46 chromosomes including translocation (9;22).

TREATMENT: Corpora cavernosa aspiration was done. Terbutaline was given. Patient was started and maintained on hydroxyurea and presently enrolled in Imitanib study.

OUTCOME: There was resolution of priapism after the corpus cavernosa aspiration and initiation of hydroxyurea and the white blood cell count had decreased after initiation of hydroxyurea.

Human ; Male ; Adult ; Priapism ; Hydroxyurea ; Terbutaline ; Pallor ; Splenomegaly ; Hyperemia ; Penile Erection ; Leukocyte Count ; Penis ; Blood Cell Count ; Leukocytes ; Anemia ; Pain

BACKGROUND: Preterm birth is a major cause of perinatal morbidity and mortality. Tocolytic drugs are used to suppress uterine contractions. The most widely used tocolytics in the Philippines are betamimetics, such as Terbutaline, which are known to have high incidence of maternal adverse effects. Nifedipine, a calcium channel blocker, is an alternative tocolytic with potentially similar efficacy and fewer maternal side effects than terbutaline.
CONCLUSION: Terbutaline and Nifedipine appeared to be equally effective tocolytic agents. However, nifedipine had tile advantage of lesser incidence of maternal adverse effects.

Human ; Tocolytic Agents ; Nifedipine ; Terbutaline ; Calcium Channel Blockers ; Uterine Contraction ; Adrenergic Beta-agonists ; Maternal Inheritance ; Iatrogenic Disease

Two selective beta 2-sympathonimetic drugs are presently used to arrest preterm labor ritodrine (Yutopar) and terbutaline. As the use of rltodrine becomes more widespread an increasing number of cases of pulmonary edema is 7eing observed Besides pulmonary edema many other complications such as myocardial ischemia, cardiac arrhyth-mias, hypotension, hypertension, cerebral vasospaun, hyperglycemia and miscellaneous metabolic alterations have been recongnized. We recently experienced a previously healthy parturient who suddenly develeped severe pulmonary edema during a cesarian section under epidural anesthesia. She had been treated wish ritodrine for 4 days in an attempt to arrest preterm labor which ultimately failed. Close, aggresaive patient care, mechanical ventilatory support with PEEP and diuretics could dramatically relieve poteotiatty fatal pulmonary edema within 24 hours. The anesthetist should be aware of the potential, life-threatening complications. It is necessry for the aneathetist to kncw how to screen, monitor and treat a patient with compllcatitans associated with tocolytic agents.
Anesthesia, Epidural ; Cesarean Section* ; Diuretics ; Female ; Humans ; Hyperglycemia ; Hypertension ; Hypotension ; Myocardial Ischemia ; Obstetric Labor, Premature ; Patient Care ; Pregnancy ; Pulmonary Edema* ; Ritodrine* ; Terbutaline ; Tocolytic Agents

Two selective beta 2-sympathonimetic drugs are presently used to arrest preterm labor ritodrine (Yutopar) and terbutaline. As the use of rltodrine becomes more widespread an increasing number of cases of pulmonary edema is 7eing observed Besides pulmonary edema many other complications such as myocardial ischemia, cardiac arrhyth-mias, hypotension, hypertension, cerebral vasospaun, hyperglycemia and miscellaneous metabolic alterations have been recongnized. We recently experienced a previously healthy parturient who suddenly develeped severe pulmonary edema during a cesarian section under epidural anesthesia. She had been treated wish ritodrine for 4 days in an attempt to arrest preterm labor which ultimately failed. Close, aggresaive patient care, mechanical ventilatory support with PEEP and diuretics could dramatically relieve poteotiatty fatal pulmonary edema within 24 hours. The anesthetist should be aware of the potential, life-threatening complications. It is necessry for the aneathetist to kncw how to screen, monitor and treat a patient with compllcatitans associated with tocolytic agents.
Anesthesia, Epidural ; Cesarean Section* ; Diuretics ; Female ; Humans ; Hyperglycemia ; Hypertension ; Hypotension ; Myocardial Ischemia ; Obstetric Labor, Premature ; Patient Care ; Pregnancy ; Pulmonary Edema* ; Ritodrine* ; Terbutaline ; Tocolytic Agents

Imbalance between sympathetic and parasympathetic nervous systems is generally considered an underlying mechanism for intraoperative erection, although local stimulation before complete sensory blockade can contribute to the problem. With the onset of erection under regional anesthesia during an operative procedure, general inhalational anesthesia must be quickly initiated to enhance venous drainage of the engorged corpora cavernosa before prolonged venous stasis. Combination therapy including ketamine, glycopyrrolate, terbutaline, and alpha-adrenergics may be available, however, the benefit-risk ratio should be considered especially in the elderly patients with cardiovascular diseases. We present a case of intraoperative erection in an elderly patient, which was resolved by applying inhalational anesthesia with remifentanil after confirmation ineffectiveness of intravenous glycopyrrolate and ketamine. We also review and discuss the treatment strategies.
Aged ; Anesthesia ; Anesthesia, Conduction ; Anesthesia, General ; Cardiovascular Diseases ; Drainage ; Glycopyrrolate ; Humans ; Ketamine ; Male ; Parasympathetic Nervous System ; Penile Erection ; Piperidines ; Surgical Procedures, Operative ; Terbutaline