Malignant transformation of teratoma in the anterior mediastinum is rare; the mass usually has a long history and is seen in older patients. We report a case of teratoma with malignant transformation in the anterior mediastinum, complicated by rupture. CT revealed a lobulated, inhomogeneous cystic mass with a fat com-ponent and wall calcifications. The lateral wall was disrupted and consolidation in the adjacent left upper lobe was noted, suggesting rupture. A heterogeneously enhanced solid portion, obliterating the fat plane between the mass and the great vessels was present in the medial aspect of the mass, and pathologic examina-tion demonstrated the presence of adenocarcinoma.
Adenocarcinoma/pathology ; Human ; Male ; Mediastinal Neoplasms/pathology/*radiography ; Mediastinum/pathology ; Middle Age ; Rupture, Spontaneous ; Teratoma/pathology/*radiography

The lung and stomach are very unusual sites for teratoma. The histologic findings of intrapulmonary and gastric teratomas are not different from those arising in usual sites, such as the ovary or testis. However, preoperative diagnosis is sometimes difficult to make partly because of unusual location. We report here two cases of teratoma, one intrapulmonary teratoma and the other gastric. The intrapulmonary teratoma in our study had an endobronchial tumor growth, which rules out mediastinal teratoma. Meanwhile gastric teratomas usually present as a submucosal tumor and most cases are reported in infancy and childhood. Gastric teratoma in this study occurred in a 27-year-old man. To the best of our knowledge, this case of intrapulmonary teratoma is the eighth and the gastric teratoma is the first to be reported in Korea.
Adult ; Case Report ; Gastrectomy ; Human ; Lung Neoplasms/surgery ; Lung Neoplasms/radiography ; Lung Neoplasms/pathology* ; Male ; Middle Age ; Stomach Neoplasms/surgery ; Stomach Neoplasms/radiography ; Stomach Neoplasms/pathology* ; Teratoma/surgery ; Teratoma/radiography ; Teratoma/pathology* ; Tomography, X-Ray Computed

A extragonadal malignant teratoma of the extremity is a rare pheonemenon. We describe a extremely rare case of malignant teratoma of the left proximal humerus in a 14-yr-old female. Radiologic evaluations, including magnetic resonance imaging, suggested a malignant bone tumor, but a pathological examination revealed an immature bony teratoma. Bone scintigraphy and positron emission tomography computed tomography scan showed increased uptake of proximal humerus but no other abnormal lesion.
Adolescent ; Bone Neoplasms/*diagnosis/pathology/radiography ; Female ; Humans ; *Humerus/radiography ; Magnetic Resonance Imaging ; Positron-Emission Tomography ; Teratoma/*diagnosis/pathology/radiography ; Tomography, X-Ray Computed

A malignant transformation or a tumor rupture is a rare complication of ovarian mature cystic teratoma (MCT). A tumor rupture in a malignant-transformed MCT has never been reported in the literature. We present the CT images of a 39-year-old woman showing a large, predominantly cystic mass in the lower abdomen, with fat-fluid-level ascites. A contrast-enhanced solid component, with regional discontinuity within the cystic lesion, is also demonstrated. The pathologic diagnosis of the ruptured MCT unveils the malignant transformation (squamous cell carcinoma) and mesenteric carcinomatosis.
Adult ; Cell Transformation, Neoplastic/pathology ; Diagnosis, Differential ; Female ; Humans ; Ovarian Neoplasms/*pathology/*radiography/surgery ; Teratoma/*pathology/*radiography/surgery ; *Tomography, X-Ray Computed

PURPOSE: We performed this study to evaluate the incidence of thoracic inlet pathologies. We also evaluated the extension of the thoracic inlet lesions to neck and/or mediastinum to determine anatomic connections between neck and mediastinum. MATERIALS AND METHODS: we evaluated chest radiographs and CT scans of the 41 patients with various pathologies involving this region. RESULTS: Thyroid lesions and malignant lymphomas were the most common pathologic lesions in this region (54%). Thoracic inlet lesions extending from mediastinum included various pathologies including thymic lesion (n=8) in the anterior mediastinum, neurogenic tumor(n=2) in the posterior mediastinum and malignant lymphoma(n=5) in the multiple compartment. Thoracic inlet lesions extending from the neck(n=9) were mostly thyroid lesions(n=8) arising in the visceral space of the neck. Thoracic inlet lesions(n=11) involving both neck and mediastinum were thyroid lesions, abscesses, thymic lesion, malignant lymphomas and cavernous hemangiomas. Thyroid lesions and cavernous hemangiomas showed remarkable enhancement on post contrast enhanced CT. Teratoma contained fat density and Two cases of abscesses contained air density. CONCLUSION: Thyroid lesions and malignant lymphomas were the most common pathologies in the thoracic inlet. There was anatomic connection between neck and mediastinum through the thoracic inlet. CT was valuale in evaluation of the location, extension, and density of the mass for the differential diaguonis of the thoracic inlet lesions.
Abscess ; Bays* ; Hemangioma, Cavernous ; Humans ; Incidence ; Lymphoma ; Mediastinum ; Neck ; Pathology ; Radiography, Thoracic ; Teratoma ; Thyroid Gland ; Tomography, X-Ray Computed

A rare case of intraventricular germinoma in the third ventricle, which occurred 30 months after total removal of mature teratoma on the same location in a 29- yr-old man is presented. Recurrence is supposed to represent an acceleration of localized dysplastic processes of totipotent germ cells present in the midline neuraxis or a growth of unidentified microscopic residue of germinoma component in mature teratoma. Although the radiation therapy after total removal of mature teratoma is still controversial, careful follow-up is warranted for evaluating a possible recurrence of other germ cell tumors.
Adult ; Cerebral Ventricle Neoplasms/classification/pathology/*radiography/surgery ; Germinoma/classification/pathology/*radiography/surgery ; Humans ; Magnetic Resonance Imaging ; Male ; Neoplasms, Second Primary/classification/pathology/*radiography/surgery ; Teratoma/complications/*surgery ; Tomography, X-Ray Computed ; Ventriculoperitoneal Shunt

We report an unusual case of 9.5-cm-sized embryonal rhabdomyosarcoma arose from a mediastinal mature teratoma in a 46-yr-old man. A man presented with chest trauma as a result of an accident at 10 September 2011. On chest X-ray, an anterior mediastinal mass was detected. To obtain further information, chest computed tomography (CT) with contrast enhancement was performed, revealing an anterior mediastinal mass. Complete surgical excision was performed and entire specimen was evaluated. Pathologic diagnosis was embryonal rhabdomyosarcoma arising in mature cystic teratoma. After surgical excision, two cycles of dactinomycin-based chemotherapy were performed. Lung metastasis was detected on follow up CT in September 2012, and wedge resection was performed. Pathological finding of the lung lesion showed same feature with that of primary rhabdomyosarcoma.
Antibiotics, Antineoplastic/therapeutic use ; Dactinomycin/therapeutic use ; Desmin/metabolism ; Humans ; Immunohistochemistry ; Lung Neoplasms/radiography/secondary/surgery ; Male ; Mediastinal Neoplasms/*diagnosis/pathology ; Middle Aged ; Neoplasms, Germ Cell and Embryonal/drug therapy/*radiography/surgery ; Rhabdomyosarcoma, Embryonal/drug therapy/*radiography/surgery ; Teratoma/*diagnosis/pathology ; Tomography, X-Ray Computed