1.Retroperitoneal teratoma with predominance of nephroblastic elements: a case report.
Youn Wha KIM ; Yong Koo PARK ; Soo Myung OH ; Moon Ho YANG
Journal of Korean Medical Science 1990;5(4):237-242
The morphological features of a retroperitoneal teratoma in a 10-month-old girl are reported. Unlike the usual pattern of the teratoma, this tumor was composed predominantly of nephroblastomatous tissue. Histologically, glomeruloid and tubular structures were identified in nests of undifferentiated blastemal elements. Hyaline cartilage, adipose tissue, glial tissue and glands lined by mucin-secreting columnar epithelium were minor elements. A focal cystic structure lined by thin flattened epithelium was also noted. Retroperitoneal teratoma with predominance of nephroblastic elements is of interest not only because of its rarity but also because it needs to be differentiated from extrarenal Wilms' tumor, since both of these tumors have different origins.
Diagnosis, Differential
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Female
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Humans
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Infant, Newborn
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Kidney Neoplasms/*pathology
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Magnetic Resonance Imaging
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Retroperitoneal Neoplasms/drug therapy/*pathology/surgery
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Teratoma/drug therapy/*pathology/surgery
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Wilms Tumor/*pathology
2.Metaplastic carcinoma of the right breast and simultaneous giant ovarian teratoma: a case report.
Chinese Journal of Cancer 2012;31(10):500-504
We describe here a female patient who presented with a breast mass and giant abdominal mass. Fine needle aspiration cytology of the breast mass and histological examination after modified radical mastectomy confirmed metaplastic carcinoma of the breast. The epithelial components were formed by infiltrating ductal carcinoma with poor differentiation, and the sarcomatous components were formed by fibrosarcoma and osteosarcoma. Histological examination of the abdominal mass confirmed ovarian teratoma. The patient underwent modified radical mastectomy of the right breast and laparoscopic excision of the abdominal mass in the lower right quadrant. Having underwent six courses of chemotherapy, the patient is now in her tenth month after surgery and under follow-up, and she has no relapsed disease. These two diseases have never seen in one patient before. The case we report here provides some new data for research and clinical experience and it may also provide a new insight into the relationship between metaplastic breast carcinoma and ovarian teratoma.
Biopsy, Fine-Needle
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Breast Neoplasms
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drug therapy
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metabolism
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pathology
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surgery
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Female
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Follow-Up Studies
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Humans
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Mastectomy, Modified Radical
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Middle Aged
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Neoplasms, Multiple Primary
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drug therapy
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metabolism
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pathology
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surgery
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Ovarian Neoplasms
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drug therapy
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pathology
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surgery
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Receptor, ErbB-2
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metabolism
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Sarcoma, Myeloid
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drug therapy
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metabolism
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pathology
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surgery
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Teratoma
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drug therapy
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pathology
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surgery
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Vimentin
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metabolism
3.Clinicopathologic and prognostic study of pediatric immature teratoma.
Wen-ping YANG ; Yin ZOU ; Chuan-sheng HUANG ; Shu-zheng ZHANG ; Qiang XIAO ; Kang-lin DAI ; Hua-sheng ZHONG ; Xiao-jun XIONG
Chinese Journal of Pathology 2007;36(10):666-671
OBJECTIVETo study the clinicopathologic features and biologic behavior of pediatric immature teratoma.
METHODSThe clinical data, pathologic features, immunohistochemical findings (for cyclin D1, P27 and Ki-67) and follow-up information of 39 cases of pediatric immature teratoma were analyzed.
RESULTSAmongst the 39 cases studied, 12 arose in the sacrococcygeal region, 12 in testis, 5 in retroperitoneum, 4 in ovary, 4 in abdomen and 2 in mediastinum. Histologically, 16 cases were of grade 1, 8 cases of grade 2 and 15 cases of grade 3. Seven of the cases contained foci of yolk sac tumor. Immature neuroepithelial features used in histologic grading included the presence of primitive neural tubules, immature rosettes, undifferentiated neuroblastoma cells and primitive neuroectodermal structures. Immunohistochemical study showed that cyclin D1 was positive in 3 cases of grade 1 tumors, 4 cases of grade 2 tumors and 9 cases of grade 3 tumors. The positivity rates for p27 were 8, 3 and 6 cases respectively, while those for Ki-67 were 3, 4 and 13 cases respectively. Follow-up data were available in 30 cases. Three of them, including 2 cases with histologic grade 3 (with or without yolk sac tumor component), recurred after operation.
CONCLUSIONSThe expression of cyclin D1 and Ki-67 is a useful adjunct in histologic grading. On the other hand, p27 overexpression shows little correlation with tumor grade. The prognosis of immature teratoma in children is different from that in adults. Sacrococcygeal immature teratoma occurring in patients younger than 1 year old and with low histologic grade do not require postoperative chemotherapy if the tumor is completely excised. Similarly, for testicular immature teratoma occurring in patients below 1 year of age, regardless of tumor grading, need no adjunctive therapy. On the other hand, ovarian immature teratoma with high histologic grade requires postoperative chemotherapy, regardless of age of the patients. The presence of microscopic foci of yolk sac tumor is a useful predictor of recurrence in pediatric immature teratoma.
Adolescent ; Cyclin D1 ; metabolism ; Endodermal Sinus Tumor ; drug therapy ; metabolism ; pathology ; surgery ; Female ; Follow-Up Studies ; Humans ; Infant ; Infant, Newborn ; Ki-67 Antigen ; metabolism ; Male ; Mediastinal Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Neoplasm Recurrence, Local ; Neoplasm Staging ; Ovarian Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Proliferating Cell Nuclear Antigen ; metabolism ; Retroperitoneal Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; Sacrococcygeal Region ; Survival Rate ; Teratoma ; drug therapy ; metabolism ; pathology ; surgery ; Testicular Neoplasms ; drug therapy ; metabolism ; pathology ; surgery ; alpha-Fetoproteins ; metabolism
4.Malignant ovarian melanoma with extensive pelvic and peritoneal metastasis: a case report and literature review.
Rong GAO ; Nai-Fu LIU ; Xiu-Gui SHENG
Chinese Journal of Cancer 2010;29(4):460-462
Adnexa Uteri
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surgery
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Diagnosis, Differential
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Female
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Humans
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Melanoma
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drug therapy
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pathology
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secondary
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surgery
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Melanosis
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pathology
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Middle Aged
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Ovarian Neoplasms
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drug therapy
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pathology
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surgery
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Pelvic Neoplasms
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secondary
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Peritoneal Neoplasms
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secondary
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Teratoma
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drug therapy
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pathology
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secondary
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surgery
5.Malignant ectomesenchymoma of left vulva in childhood: report of a case.
Wen-Ping YANG ; Liang FENG ; Yan WU ; Yin ZOU ; Song-Tao ZENG ; Hua-Sheng ZHONG ; Hong-Yan XU ; Qiang XIAO
Chinese Journal of Pathology 2009;38(10):713-714
Desmin
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metabolism
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Diagnosis, Differential
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Female
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Follow-Up Studies
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Humans
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Infant
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Ki-67 Antigen
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metabolism
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Mesenchymoma
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drug therapy
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metabolism
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pathology
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surgery
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Nerve Sheath Neoplasms
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metabolism
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pathology
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Phosphopyruvate Hydratase
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metabolism
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Rhabdomyosarcoma, Embryonal
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drug therapy
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metabolism
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pathology
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surgery
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Teratoma
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metabolism
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pathology
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Vulvar Neoplasms
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drug therapy
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metabolism
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pathology
;
surgery
6.Signet ring cell carcinoma arising from mature cystic teratoma of the ovary.
Hong-fang ZHENG ; Bao-yu JIANG ; Dan-hua SHEN
Chinese Journal of Pathology 2005;34(9):610-611
Adult
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Antineoplastic Agents
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therapeutic use
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Carcinoembryonic Antigen
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metabolism
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Carcinoma, Signet Ring Cell
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drug therapy
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metabolism
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pathology
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surgery
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Cell Transformation, Neoplastic
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pathology
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Cisplatin
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therapeutic use
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Female
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Humans
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Hysterectomy
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Keratin-20
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metabolism
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Ovarian Neoplasms
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drug therapy
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metabolism
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pathology
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surgery
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Teratoma
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drug therapy
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metabolism
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pathology
;
surgery
7.Ependymoma of ovary: report of a case.
Kai-xuan YANG ; Yu WAN ; Lian XU ; Liang SUN ; Zheng-yu LI
Chinese Journal of Pathology 2007;36(8):568-569
Adult
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Antineoplastic Combined Chemotherapy Protocols
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therapeutic use
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Cyclophosphamide
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therapeutic use
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Cystadenocarcinoma, Papillary
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pathology
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Dactinomycin
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therapeutic use
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Diagnosis, Differential
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Ependymoma
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drug therapy
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metabolism
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pathology
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surgery
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Female
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Follow-Up Studies
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Glial Fibrillary Acidic Protein
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metabolism
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Humans
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Hysterectomy
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Ovarian Neoplasms
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drug therapy
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metabolism
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pathology
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surgery
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Ovariectomy
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Teratoma
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pathology
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Vimentin
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metabolism
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Vincristine
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therapeutic use
8.Embryonal Rhabdomyosarcoma Arising from a Mediastinal Teratoma: An Unusual Case Report.
Young Joon RYU ; Su Hyun YOO ; Min Jung JUNG ; Sejin JANG ; Kyung Ja CHO
Journal of Korean Medical Science 2013;28(3):476-479
We report an unusual case of 9.5-cm-sized embryonal rhabdomyosarcoma arose from a mediastinal mature teratoma in a 46-yr-old man. A man presented with chest trauma as a result of an accident at 10 September 2011. On chest X-ray, an anterior mediastinal mass was detected. To obtain further information, chest computed tomography (CT) with contrast enhancement was performed, revealing an anterior mediastinal mass. Complete surgical excision was performed and entire specimen was evaluated. Pathologic diagnosis was embryonal rhabdomyosarcoma arising in mature cystic teratoma. After surgical excision, two cycles of dactinomycin-based chemotherapy were performed. Lung metastasis was detected on follow up CT in September 2012, and wedge resection was performed. Pathological finding of the lung lesion showed same feature with that of primary rhabdomyosarcoma.
Antibiotics, Antineoplastic/therapeutic use
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Dactinomycin/therapeutic use
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Desmin/metabolism
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Humans
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Immunohistochemistry
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Lung Neoplasms/radiography/secondary/surgery
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Male
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Mediastinal Neoplasms/*diagnosis/pathology
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Middle Aged
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Neoplasms, Germ Cell and Embryonal/drug therapy/*radiography/surgery
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Rhabdomyosarcoma, Embryonal/drug therapy/*radiography/surgery
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Teratoma/*diagnosis/pathology
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Tomography, X-Ray Computed