Thyroid hormones play important roles in growth, development, and metabolism of various cells and tissues. It has been assumed for a long time that thyroid hormones are lipophilic and enter cells by passive diffusion, but it has become increasingly clear that cellular uptake and efflux of thyroid hormones are mediated by transporters. The discovery of these thyroid hormone transporters will lead to a better understanding of the tissuespecific regulation of thyroid hormones.

Antibodies, Antineutrophil Cytoplasmic ; analysis ; immunology ; Antibodies, Antinuclear ; analysis ; immunology ; Antigens, Nuclear ; immunology ; Arthritis, Juvenile ; immunology ; Autoantibodies ; analysis ; immunology ; Humans ; Monitoring, Physiologic ; methods ; Nucleosomes ; immunology ; Phospholipids ; immunology ; Rheumatic Diseases ; immunology ; physiopathology

Objective To explore the possibility of finding pulmonary embolish by CT scan. Methods 20 cases of patients with pulmonary embolism comfirmed by CTA were selected. The CT scan was compared with the enhance film in the same level of contrast observation site. Results 12 cases found in plain site with the CTA form show abnormal density within the same lumen shadow. Indirect signs of bronchial artery dilatation except plain and outside the CTA showed no difference. Conclusion Pulmonary embolism in the carefully observed before enhanced large artery can be found within the thrombus.

hypothyroidism is a common subclinical disease in endocrinology. Its diagnosis is based on an elevated serum TSH but normal FT 4 levels. The adverse outcome of subclinical hypothyroidism is progressing to overt hypothyroidism with an increased risk for atherosclerosis and myocardial infarction . Two factors may affect the development of overt hypothyroidism: the levels of serum TSH and thyroid autoantibodies and both factors have additional effects on the outcome. The benefits of treatment with T 4for preventing the development of overt hypothyroidism is not yet certain; subclinical hypothyroidism is a strong indicator of risk for atherosclerosis and myocardial infarction, just like other known major risk fators such as hypercholestrolemia, hypertension, smoking and diabetes (odds ratio for aortic atherosclerosis 1.9; odds ratio for myocardial infarction 3.1). The treatment with T 4 for the patients could reduce the levels of serum cholesterol. The effects of subclinical hypothyroidism in pregnant women on the IQ of their children have been widely focused. According to the results from a published epidemiological study, the normal reference values of TSH, thyroid peroxidase antibody (TPOAb) and thyroglobulin antibody (TgAb) detected by immunochemiluminesence assay (ICMA) method and the cut-off values of TPOAb and TgAb associated with thyroid diseases have been proposed.

Five mongrel dogs were used to investigate the dynamic changes of beta-cndo-rphin-Uke-immunoriactivity(ir-?-EP)and thdr correlation with hemodynamics during intestinal ischemia shock.It was shown that plasma levels of ir-?-EP were increased significantly during shock and were significantly correlated with the decrease in MAP, CO, SV,and CI.Our results give the direct evidence that endogenous opiate beta-endorphin is involved in the cardiovascular pathophysiology of intestinal ischemia shock.

Objective To analyse the clinical and X-ray manifestations of pulmonary infiltration in mediastinal malignant lymphoma in order to improve the knowledge of this disease. Methods The clinical and X-ray features of pulmonary infiltration in mediastinal malignant lymphoma confirmed by clinic and pathology were retrospectively analysed. Results There were Hodgkin’s disease (HD)in 9, Non-Hodgkin disease(N-HD)in 11 and no classified in 5. Imaging findings included: patch infiltration in pneumonic type(in 8 cases), reticular shadow in interstitial type(in 7 cases).Lobulated mass in mass type(in 1 case).Node(0.3~0.8 cm in diameter)in nodular type (in 1 case),patch infiltration together with reticular in mixed type (in 6 cases),and extremely small nodules distributed throughout the entire lung in milliary type (in 2 cases).After chemico-radiotherapy, 12 cases were improved, 9 cases were worse and 4 cases were no change.Conclusion The pulmonary infiltration in mediastinal malignant lymphoma is most seen in the pneumonic,interstitical and mixed type,chemico-radiotherapy is an ideal therapeutic method for this disease.

Recently, more and more attention have been paid to the impact of maternal thyroid hormones on neuropsychologic development of offspring. In the first 20 weeks of gestation, neuropsychologic development of the fetus is mostly dependent on thyroxine from the mother. Limited epidemiological data showed that full-scale WISC IQs averaged 7 points lower among children born to mothers with undiagnosed thyroid deficiency during pregnancy, in comparison with control children. The main cause of subclinical maternal hypothyroidism is autoimmune thyroiditis. Data from basic studies have confirmed the impacts of maternal thyroid hormones on the neurodevelopmental outcomes of offspring. In a Chinese female population, the positive rate of thyroid autoantibodies was 11.0%, and the prevalence of postpartum thyroiditis was 11.9%. Hence, it is necessary to set up a screening schedule for subclinical hypothyroidism and autoimmne thyroiditis in pregnant women, which is of great value for the health of both women and children.

For the first time,the iodine-induced thyroid diseases group of China Medical University has finished a five-year prospective epidemiological study on the incidences of thyroid diseases in the three communities with various levels of iodine intake.The results indicated that increased incidences of subclinical hypothyroidism and autoimmune thyroiditis in the communities with more than adequate and excessive iodine intake.The individuals with positive thyroid autoantibodies at baseline more likely became hypothyroid due to more than adequate and excessive iodine intake.These adverse effects are mainly involved in the susceptible populations for thyroid diseases.Hence it appears to be reasonable that iodine supplementation should be conducted by localization and individualization.

Objectives:To evaluate the diagnostie value of 16 row helical CT with application of volume viewer. Methods:A retrospective analysis of 52 patienis'numerical data was made. All patients with clinical suspected cerebral vessels disease were detected by the 16 row helical CT angiography with application of voltume viewer, and the imaging data were compared with those of DSA or pathology. Results:of 52 cases,a total of 33 intracranial aneurysms were detected by the application of volume viewer, which clearly displayed the body, neck and parenl artery of intracranial aneurysms, and showed the aneurysms relation with peripheral vessels and cranioaural. In 52cases, 8 cases of cerebral vascular malformations showed Ihe form, the size and the hemisphere of cacogenesis cerehral vessels, as well as the amount of feeding artery and draining vein. In 2 case Moyamoya disease, 16 row helical CT angiography showed paragraph of obliteration Cerebral vessels and branch stem paraplasm. Conclusion:There is clinical application value in 16 row helical CT angiography for the diagnosis of cerehral vessels disease, which provides guidance fur clinical treatment.

Objective To explore the TCM syndrome and its distribution regularity of premature ovarian failure(POF) as well as the relation between the etiological factor and TCM syndrome of it.Methods The pathogenetic condition and etiological factor of 122 patients with POF were surveyed,and TCM syndrome differentiation was carried out on them.Results The TCM symptoms of POF manifested the tendency of variety.Among the 122 cases,Gan-stagnation and Shen-deficiency type accounted for 33.61% of them,Gan-Shen yin deficiency type for 18.03%,Pi-Shen yang deficiency type for 15.57%,Jin damage due to excessive heat type for 15.57%,Shen-deficiency blood stasis type for 8.20%,and Gan-stagnation and Pi-deficiency type for 7.38%.The influence of modern living environment and life style to the disease was found in 68.03% of the patients’ case history.31.15% of the patients was induced by emotion,31.97% by drugs and disease,and 4.92% by both of them.In patients induced by emotion,the proportion of Gan-stagnation and Shen-deficiency type was the highest as compared with the other types(P0.05).Conclusion Gan-stagnation and Shen-deficiency type,Gan-Shen yin deficiency,Pi-Shen yang deficiency type and Jin damage due to excessive heat are the commonly encountered syndromes in patients with POF.Besides the congenital,Shen-Qi and Chong-Ren Qi-blood insufficiency as well as the genetic factor,the modern living environment and life style have the promotion in the genesis of POF.