1.Experimental researches on treatment of end-stage nephropathy with stem cells transplantation
Journal of Interventional Radiology 2006;0(10):-
Stem cell possesses the capability of self-regeneration and multidirectional differentiation.Although renal transplantation being the best way for the treatment of end-stage nephropathy,the shortage of donor kidney arouses the treatment with transplantation of stem cells taking emphasis in recent years.The process and mechanism of this therapy are complicated and the authors review in detail the experimental research advancement on stem cells engraftment for the treatment.The correlative interventional technology is also evaluated.(J Intervent Radiol,2006,15: 632-635)
2.New Century Educational Objectives of Medical Specialty in the Field of International Vision and Reference
Chinese Journal of Medical Education Research 2002;0(01):-
In recent years, many countries in the world has established the projects of medical education objectives. The goals for the projects are to develop a consensus within the medical education community on the attributes that medical students should possess at the time of graduation, and to set several learning objectives that can guide each medical school as it establishes its own program.Chinese medical schools should feel a sense of urgency in responding to the intent of these actives.
3.Nicotine effects on the osseointegration of implants with different treatments
Xin SUN ; Yudong HOU ; Teng TENG ; Pengfei XUE ; Shunzhen LIU
Chinese Journal of Tissue Engineering Research 2014;(8):1149-1154
BACKGROUND:Studies have confirmed that nicotine affects the activity of osteoblasts, osteoclasts, fibroblasts and erythrocytes.
OBJECTIVE:To study the nicotine effects on osseointegration and the expression of osteoprotegerin and bone morphogenetic protein 2 after implantation of dental implants with surface treatment by sandblasting or acid etching.
METHODS:Twenty-four Sprague-Dawley rats were randomly assigned to two groups and received daily injections for 2 weeks as folows: Nicotine 2 mg/kg twice for experimental group, saline solution for control group. Then the titanium implants with surface sandblasting or acid etching were implanted into the tibiae folowed by continuous nicotine or normal saline injection. At weeks 2 and 4 after implantation, the implants and surrounding bone tissue were prepared for CT, X-ray and hematoxylin-eosin staining examinations to evaluate bone healing and expression levels of bone-related genes were measured by quantitative RT-PCR.
RESULTS AND CONCLUSION: Compared with the control groups, the degree of osseointegration and the expression of osteoprotegerin and bone morphogenetic protein 2 in the experimental groups were decreased significantly (P < 0.05), except that the expression of bone morphogenetic protein 2 in the experimental group with acid etching was not significantly reduced. In addition, the expression of bone morphogenetic protein 2 in the experimental group with acid etching was higher than that in the experimental group with sandblasting at 2 weeks after implantation (P < 0.05). The X-ray and CT show that the quantities of new generation bone and the degree of bone mineralization of the sandblasting group were significant lower than those of the acid etching group under the intervention of nicotine. Hematoxylin-eosin staining showed that the activity and quantity of osteoblasts around the implants down-regulated significantly, but acid etching-treated implants showed better outcomes than sandblasting-treated implants.
4.Capsular Warning Syndrome
Yanan SUN ; Jijun TENG ; Fengjiao SUN
International Journal of Cerebrovascular Diseases 2013;21(12):928-932
Capsular warning syndrome (CWS) is a subtype of recurrent stereotyped transient ischemic attacks that heralds a subsequent stroke.The mainly presumed mechanism is repeated bursts of ischemia in the region of penetrating arteries,since the structural changes of large arteries is rare in series of imaging examinations.The majority of the infarct is located in the internal capsule or pontine.CWS is usually therapeutically resistant to simple traditional antithrombotic treatment,while combined antiplatelet treatment,thrombolysis,endovascular intervention and antiepileptics may protect part of the patients from developing into permanent infarcts.
6.Clinical analysis of 26 patients with thyroid Hiirthle cell tumor
Jixian CHEN ; Lisong TENG ; Limin SUN
Chinese Journal of Endocrinology and Metabolism 2009;25(4):420-421
Unilateral thyroidectomy (lobeetomy) plus (or) isthmectomy were performed surgically and all patients recovered satisfactorily. No recurrence was found after a mean of 37 months follow-up(9 months-6 years).
7.Analysis of clinicopathological characters for IgG4-related disease
Weixiang ZHONG ; Ke SUN ; Xiaodong TENG
Chinese Journal of Clinical and Experimental Pathology 2015;(3):289-292
Purpose To study the clinicopathological features and immunohistochemical characteristics of IgG4-related disease. Meth-ods The microscopic characteristics and immunohistochemical staining (EnVision) of IgG, IgG4, CD138 and CD34 have been per-formed on 12 cases of IgG4-related disease. Results IgG4-related disease were characterized by diffuse fibrosis, accompanied with in-filtrating of dense lymphocytes and plasma cells surrounding neurovascular and occlusive phlebitis. Immunohistochemical staining re-sults showed the ratio of IgG4+/IgG+ cells were over 40%. Conclusions IgG4-related disease is absent of characteristic clinical and radiographic features and is easily misdiagnosed as tumor. Preoperative serum IgG4 detection could be used as the prior examina-tion for the suspected cases.
8.Cerebral microbleeds in patients with ischemic stroke
Yingxue SUN ; Lina WANG ; Jijun TENG
International Journal of Cerebrovascular Diseases 2015;23(10):777-780
Cerebral microbleeds are a research focus in the field of cerebrovascular disease in recent years.Cerebral microbleeds have important influence on recurrent stroke,hemorrhagic transformation,cognitive impairment,and treatment options in patients with ischemic stroke.The article reviews the above aspects.
9.Advances in the mechanisms of mesenchymal stem cells in the treatment of sepsis
Yongsheng TENG ; Falyu SUN ; Dong SHANG
Chinese Critical Care Medicine 2016;28(5):469-473
Sepsis is defined as an organ dysfunction caused by systemic inflammatory response induced by infection,and may eventually developed into multiple organ failure (MOF).The onset of sepsis often involves the activation of inflammatory cells,over expression of inflammatory cytokines,immune dysfunction,damage of tissue and organ,excessive apoptosis of cell.Mesenchymal stem cells (MSCs) have a wide range of biological activities,including anti-inflammatory,antibacterial,immune regulation,regeneration and repair of tissue and organ,anti-apoptosis,etc.In recent years,a large number of preclinical studies had demonstrated that MSCs has good actions on sepsis.The purpose of this review is to describe the mechanism of MSCs in the treatment of sepsis,and to point out the possible clinical challenges.
10.Determination of 9 Residual Solvents in Irbesartan by GC
Huaifeng TENG ; Xiaobo TONG ; Xiaojuan SUN
China Pharmacist 2015;(2):317-319
Objective:To establish a method for the determination of 9 residual solvents including methanol, ethanol, acetone, i-sopropyl alcohol, acetonitrile, dichloromethane, methyl-butyl ether, ethyl acetate and methylbenzene by capillary gas chromatography. Methods:The residual solvents were separated on a Kromat KB-624(30 m × 0. 53 mm,3. 0 μm) capillary chromatographic column with temperature programming. Nitrogen was used as the carrier gas with the flow rate of 5. 0 ml·min-1 . The temperature of injector was 200 ℃. A flame ionization detector was used with the temperature of 250℃. The containers of head-space injector were in equilib-rium at 80℃ for 20 min. Dimethyl sulfoxide was used as the solvent and an external standard method was used for the determination of the 9 residual solvents. The injection volume was 1 ml. Results:Under the above conditions, the 9 solvents were well separated. There was good linear relationship within the concentration range, and the correlation coefficients were no less than 0. 9991. The average re-coveries were 99. 08%-105. 14% with RSD of 1. 1%-3. 3%(n=9). The LOQ was 15. 68, 25. 45, 1. 09, 10. 61, 4. 54, 5. 73, 1. 04, 10. 58 and 1. 89 μg, respectively. Conclusion:The established method is simple, accurate and reproducible, and can be used in the determination of residual solvents in irbesartan API.