1.In vitro antibacterial potency of teicoplanin by the disc diffusion method.
Pyung Han HWANG ; Jung Soo KIM ; Yang Keun LEE ; Mi Ae YOON ; Sam Im CHOI
Korean Journal of Infectious Diseases 1993;25(1):33-43
No abstract available.
Diffusion*
;
Teicoplanin*
2.Teicoplanin plus aminoglycoside therapy in febrile granulocytopenic patients.
Jung Hee KIM ; Joon Shik KIM ; Wan Kyoo UH ; Si Yung KIM ; Hwi Joong YOON ; Kyung Sam CHO
Korean Journal of Infectious Diseases 1993;25(3):231-237
No abstract available.
Humans
;
Teicoplanin*
3.Is Therapeutic Drug Monitoring of Teicoplanin Useful?.
Infection and Chemotherapy 2014;46(1):64-65
No abstract available.
Drug Monitoring*
;
Teicoplanin*
4.Clinical efficacy of teicoplanin in gram-positive bacterial infection.
Kang Hyun CHOI ; Jae Hoon SONG ; Koo Yung CHO ; Hyung Ho KIM ; Bin YOO ; Chul Won SUH
Korean Journal of Infectious Diseases 1993;25(1):57-62
No abstract available.
Gram-Positive Bacterial Infections*
;
Teicoplanin*
5.Efficacy of teicoplanin in gram-positive bacterial infection.
Ji So RYU ; Jun Hee WOO ; Kee Won KIM ; Hyun Tae KIM ; Yong Hun KIM
Korean Journal of Infectious Diseases 1992;24(3):183-189
No abstract available.
Gram-Positive Bacterial Infections*
;
Teicoplanin*
6.Comparison of Antimicrobial Susceptibility Testing Methods to Detect Glycopeptide Resistance in Enterococci: E-test, Vitek, Disk Diffusion and Agar Dilution Method.
Soo Youn LEE ; Jin Hi PARK ; Hyang Sook PARK ; Mi Ae LEE ; Eun Suk KANG ; Ki Sook HONG
Korean Journal of Clinical Pathology 2000;20(3):301-307
BACKGROUNDS: The emergence of resistant strains to glycopeptide in enterococci(GRE) is increasingly serious problem in the worldwide. Automated methods and disk diffusion test have difficulties in detecting vancomycin resistance of some strains of vancomycin-resistant enterococci(VRE), especially having vanC genotypes. And a few studies have been done assessing the ability of antimicrobial susceptibility testing methods to detect teicoplanin resistance in enterococci. METHODS: We evaluated the abilities of two commercial kits including Vitek GPS-IZ(BioMerieux, Vitek, Inc., USA) and E-test(AB Biodisk, USA), and disk diffusion test to detect glycopeptide resistance using 34 strains of vanA and 15 strains of vanC1/C2 VRE. We compared the results with those of standard agar dilution test. RESULTS: In detecting vancomycin resistance, no very major or major errors were seen, and minor error rates were observed with disk diffusion(25%), Vitek GPS-IZ(20%) and E-test(8%). Overall sensitivities of all three methods in detecting vancomycin resistance of vanA VRE were 97-100%, but sensitivities in detecting vancomycin resistance of vanC VRE were 20% in disk diffusion, 87% in E-test and 87% in Vitek GPS-IZ. In detecting teicoplanin resistance, very major error rate was high in Vitek GPS-IZ(47%), but no very major or major errors were seen in disk diffusion and E-test; minor error rates of 2% and 6% were seen in Vitek GPS-IZ and E-test, respectively. CONCLUSION: All three methods detect vancomycin resistance of vanA VRE, but they continue to demonstrate problems in detecting low-level vancomycin resistance and the Vitek GPS-IZ is difficult to detect teicoplanin resistance in enterococci.
Agar*
;
Diffusion*
;
Genotype
;
Teicoplanin
;
Vancomycin Resistance
7.Susceptibility of Glycopeptide-Resistant Enterococci to Linezolid, Quinupristin/dalfopristin, Tigecycline and Daptomycin in a Tertiary Greek Hospital.
Sofia MARAKI ; George SAMONIS ; Dimitra DIMOPOULOU ; Elpis MANTADAKIS
Infection and Chemotherapy 2014;46(4):253-256
We investigated the antibiotic susceptibility of glycopeptide-resistant enterococci (GRE). Seventy consecutive GRE were tested. Sixty-two isolates were identified as Enterococcus faecium (88.6%), and 8 (11.4%) as Enterococcus faecalis. All strains were susceptible to linezolid and daptomycin, while 17.1% (12/70) and 11.4% (8/70) were resistant to quinupristin/dalfopristin (QD) and tigecycline, respectively. All E. faecalis isolates were resistant to QD, while 4 of 62 (6.5%) E. faecium isolates were resistant to QD. All E. faecalis isolates were susceptible to tigecycline, while 14.5% (9/62) E. faecium isolates were resistant. Continued surveillance of GRE antibiotic susceptibilities is important for combating these multi-resistant nosocomial pathogens.
Daptomycin*
;
Enterococcus faecalis
;
Enterococcus faecium
;
Linezolid
;
Teicoplanin
8.Prevalence of Teicoplanin-resistant Staphylococci and Evaluation of the Disk Diffusion Test for Testing the Susceptibility of Staphylococci to Teicoplanin.
Myungshin KIM ; Yeon Joon PARK ; Byung Kee KIM ; Sun Moo KIM ; Sang In SHIM
Korean Journal of Infectious Diseases 1998;30(2):151-155
BACKGROUND: Teicoplanin is a glycopeptide antimicrobial agent effective against methicillin-resistant staphylococci. Decreased susceptibility of staphylococci to glycopeptides has been increasing. Teicoplanin diffuses poorly in agar and therefore the correlation between the inhibition zone diameter and the minimal inhibitory concentration(MIC) is rather poor. The purpose of this study was to evaluate the prevalence of teicoplanin-resistant staphylococci and to assess the reliability of inhibition zone diameters for determining the susceptibility of staphylococci to teicoplanin by comparing the results of the agar dilution MICs. METHODS: From June to August 1997, 290 clinical isolates of staphylococci(77 coagulase negative staphylococci(CNS), 213 Staphylococcus aureus) were collected. The antimicrobial susceptibilities to teicoplanin were determined by inhibition zone diameter and the results were compared with the MICs determined by the agar dilution method. RESULTS: Among 77 CNS strains, 75(97.4%) were susceptible and 2(2.6%) were intermediate by agar dilution method and all 213 strains of S. aureus were susceptible to teicoplanin. There was a poor correlation(r=0.50) between the zone diameters of inhibition and agar dilution MICs. In comparison with the results of disk diffusion test and agar dilution MIC, eight (2.8%) out of 290 isolates showed discrepancies (major error rates : 0.3%, minor error rates: 2.4%). CONCLUSIONS: Two(2.6%) out of 77 strains of CNS and none of 213 S. aureus strains revealed decreased susceptibility to teicoplanin. And the inhibition zone diameter was less reliable in determining the susceptibility of staphylococci than MICs. Therefore, the more effective and convenient method is needed.
Agar
;
Coagulase
;
Diffusion*
;
Glycopeptides
;
Methicillin Resistance
;
Prevalence*
;
Staphylococcus
;
Teicoplanin*
9.Incidence of Coagulase-Negative Staphylococci with Reduced Susceptibilities to Glycopeptides and Comparison of Test Methods.
Chang Seok KI ; Seong Kyu LEE ; Jang Ho LEE ; Nam Yong LEE
Korean Journal of Clinical Microbiology 1998;1(1):75-81
BACKGROUND: We tried to evaluate the incidence and clinical significance of coagulase-negative staphylococci (CoNS) with reduced susceptibilities to glycopeptides. In addition, the ability of disk diffusion and Vitek system to detect CoNS with reduced susceptibilities to glycopeptides were compared with the standard agar dilution method. METHODS: One hundred and nineteen clinical isolates of CoNS were recovered at Samsung Medical Center from June to July 1998 and were examined for their susceptibilities to vancomycin and teicoplanin by disk diffusion method (30-microgram disk), Vitek system with GPS-AA card, and agar dilution for the determination of MICs. The records of all patients, from whom CoNS with decreased susceptibility to glycopeptide was isolated, were reviewed. RESULTS: All CoNS showed uniform susceptibility to vancomycin by all three methods but 11 strains (9.2%) exhibited reduced susceptibilities to teicoplanin (MICs, 16 to 32 microgram/mL). All but suspected colonized strains were nosocomially acquired and were isolated from 7 different wards. None were previously treated with teicoplanin. The concordance rates of disk diffusion method and Vitek system with agar dilution method were 94.1% and 84%, respectively. However, the sensitivity of disk diffusion method and Vitek system were only 50.0% and 62.5%, respectively. CONCLUSIONS: This study demonstrates that CoNS with reduced susceptibilities to glycopeptides is not uncommon and may cause true infections in clinical settings. However, neither disk diffusion method nor Vitek system could differentiate these strains from more susceptible isolates.
Agar
;
Colon
;
Diffusion
;
Glycopeptides*
;
Humans
;
Incidence*
;
Teicoplanin
;
Vancomycin
10.Storage of the split-thickness skin piece using proper antibiotics.
Journal of the Korean Society of Plastic and Reconstructive Surgeons 1998;25(6):997-1002
Todays, remnant split-thickness skin graft is stored for graft failure or for delayed grafting. Refrigerated skin is usually stored for 3 weeks, after which, cellular respiration ceaces. Even though the refrigerated skin can be used before 3 weeks after harvest, the success rate of the skin graft is usually lower than in case of fresh skin. One of the most reliable explanations is multiplication of microorganisms on the stored skin, that is, the more microorganisms on the refrigerated skin, the less the success rate of grafts. For this reasons, some kind of antibiotics have been used for storage of the split-thickness skin piece. But there is no report about the effect of antibiotics on stored skin. We want to know the effect of the antibiotics on stored skin. For this purpose, we did three experiments for qualititative bacteriology of refrigerated skin. Experiment 1 was qualititative identification of microorganisms colonizing split-thickness skin after 2 weeks storage in low temperature, and sensitivity tests for identified microorganisms. On the basis of experiment 1, the proper antibiotics were selected and samples of split-thickness skin were stored using this antibiotics. At 2 weeks after storage in low temperature, samples of split-thickness skin were cultured for identification of bacterial growth. This is experiment 2. Experiment 3 is histologic examination of the split-thickness skin involved in experiment 1 and 2.In the experiment 1, we found five kinds of microorganisms in 9 out of 30 split-thickness skin samples. The most common microorganism was coagulase negative Staphylococcus which was found in 4 samples. Through the antibiotics sensitivity test, teicoplanin was selected as the most proper antibiotics. In experiment 2, we could not find any microorganisms in 30 split-thickness skin samples. In experiment 3, there were no histologic differences in the split-thickness skin samples whether antibiotics were used or not. Through these results, we have confirms that split-thickness skin pieces are more safely stored using proper antibiotics.
Anti-Bacterial Agents*
;
Bacteriology
;
Cell Respiration
;
Coagulase
;
Colon
;
Skin*
;
Staphylococcus
;
Teicoplanin
;
Transplants