1.Prevalence of asymptomatic bacteriuria in hospitalized patients
Tegshjargal T ; Altantsetseg T ; Regzedmaa D ; Oyunchimeg D
Health Laboratory 2021;13(1):5-11
Description:
Asymptomatic bacteriuria is defined as the presence of 1x105 or more bacteria per milliliter of urine, although there are no signs of UTI [1]. Asymptomatic bacteriuria is quite common and occurs in 1-5% of healthy women before menopause. The incidence of asymptomatic bacteriuria increases in the elderly (men and women) to 4-19%. Asymptomatic bacteriuria is observed in 0.7% -27% of patients with diabetes mellitus, in 2-10% of pregnant women and in 23-89% of patients with spinal cord injury. Asymptomatic bacteriuria is rarely observed in young men and always requires differential diagnosis with chronic bacterial prostatitis[2].
Among the elderly, those in institutionalized settings such as long-term care facilities and hospitals have a higher prevalence of asymptomatic bacteriuria than those living in the community. Therefore, interest in asymptomatic bacteriuria has shifted from the general population to these groups of individuals. The prevalence varies from 2% to 10% in pregnancy and from 15% to 50% in the elderly in long-term care facilities.[3,4]
This study was undertaken to determine the prevalence of people asymptomatic bacteriuria in among hospitalized people.
Purpose:
Investigate cases of asymptomatic bacteriuria among hospitalized individuals and determine antibiotic susceptibility by type of pathogen detected in urine.
Materials and methods:
This cross-sectional study in the “I” Hospital of UB city, Mongolia. We conducted into the study 133 patients. After obtaining informed consent, a midstream clean-catch urine sample was collected in the same 24 hour time window and was evaluated for urinalysis using a dipstick test and routine culture. A positive urine culture was defined as a single urine sample with microbal growth of >105 colony- forming units of a single organism. We use 5-10% Blood agar, UTI agar, Mackkong agar and Chroma agar for a bacterial growth. Then we did antibiotic susceptibility of the determined pathogen.
Result:
The average age of the respondents was 55.9±14.6, the youngest was 17 years old and the oldest was 91 years old (CI 95% 53.4-58.5). By age group, 4.5% (n = 6) of people aged 20-30, 21.1% (n = 28) of people aged 31-45, 37.5% (n = 50) of people aged 46-60, and people over 61 years of age 36.8% (n = 49) respectively.Of the respondents, more than 56 or 54.9% (n = 73) were elderly, of which 63.9% (n = 85) were women and 36.1% (n = 48) were men.
A total of 36 (27.1%) leukocytes were detected, and 25 (34.2%) more (P-0.05) were detected in people over 56 years of age. The protein detected in 24 (18.0%) people, all over 56 years of age and more defined in men (P-0.01).
80.5% (n = 107) of those surveyed were diagnosed with the pathogens, and 54.9% were elderly (P-0.031). 82.4% of women and 77.1% of men were diagnosed with urinary pathogens.
Streptococcus 26%, E.coli 19%, Saprophyticus 13%, Enterococcus 11% and Staphylococcus 11% were detected in the analysis, and Streptococcus and E.coli (19%) accounted for a slightly higher rate of infection.
A total of 13 types of pathogens were identified, of which 53.4% were susceptible, 21.7% were moderately sensitive, and 24.9% were non-susceptible.
Discussion:
According to a study conducted by researchers at the University of Taiwan, the prevalence of asymptomatic UTI-s in the general population is 57.8%. E.Coli was also the most common bacterium in the urine [6].
In our study, there are many cases of E. coli.
Study in the United States found that the prevalence of asymptomatic bacteriuria among inpatients was 8.5%, all of them women. The most common pathogens in this study are Enterococcus bacteria. This study found that 1 in 10 people admitted to the hospital may have asymptomatic bacteriuria. [1]
Conclusion
1. Asymptomatic bacteriuria in 80.5% of those surveyed 54.9% were detected in people over 56 years of age.
2. Antibiotic susceptibility of the tested pathogens was determined as 53.4% sensitive, 21.7% moderately sensitive and 24.9% insensitive.
2.Gastric cancer: the current status and risk factors
Ganchimeg D ; Nasanjargal T ; Tegshjargal B ; Bayar D ; Bolor-Erdene T ; Batbold B ; Otgonbayar I ; Sodnomtsogt L ; Tulgaa L
Mongolian Medical Sciences 2018;186(4):68-74
Gastric cancer has been and still considered one of the most common causes of cancer-related mortality
and it continues to be a major public health issue. The incidence and mortality of gastric cancer in Mongolia is the highest in the world. For this reason, this paper provides the information about current status of gastric cancer in Mongolia in the first section. Morbidity and mortality of gastric cancer increased steadily during the last decade. In the second section we overview the most important factors that can accelerate the risk of gastric cancer. Evidence from case-control, cohort studies and meta-analysis have suggested that the risk of gastric cancer is related to several factors including genetics, Helicobacter pylori, other factors related to the environment and lifestyle. Risk factors could have different effects on the onset and the evolution of gastric cancer.
3.The effect of nutrition risk factors for esophageal and gastric cancer
Enkhmyagmar D ; Tulgaa L ; Nasanjargal T ; Batbold B ; Ganchimeg D ; Tegshjargal B ; Bolor-Erdene T ; Bayar D ; Erkhembayar E ; Chinzorig M ; Dashmaa A ; Tsegmed S
Mongolian Medical Sciences 2019;187(1):80-86
Gastric and esophageal cancer is a significant global health issue. The epidemiology of these tumors has significantly increased over the past several years especially in developing and developed countries. Many dietary exposures have been proposed to protect against or increase risk for esophageal and gastrointestinal (GI) cancers, including poor diets, foods, individual nutrients, methods of food preparation, and habits of consumption. Overweight/obese status is associated with an increased risk for many cancer types such as esophageal, gallbladder, kidney, pancreatic and
gastric cancer. The association between obesity and cancer is strong. Nowadays there is a recognized decrease in incidence and mortality of distal gastric cancer and an increase in incidence and mortality of proximal esophageal cancer. In Mongolia, gastric cancer is the second most common cancer in males and the third most common in females. It is very important to understand how diet and nutrition affect to gastric and esophageal cancers. In this review we will discuss the effect of diet in locally advanced gastro-esophageal cancer. Although we tried to conclude all published articles about gastric and esophageal cancers in Mongolia.
In this survey, is considered dietary risks into 5 groups as following;
• Insufficient nutrition education(don’t know food and nutrients significance and food hygiene, don’t know right consumption of food)
• Bad habits (hot tea and meals, salty tea and food, low consumption of fruits and vegetables, sometimes eating breakfast, most of daily energy of food in the night, high amount of sugar, a drink of caffeine, overweight and etc.)
• Food processing technology (such as overcooking, pickling, preserving, frying, excessive salt in tea fried and etc).
• Chemical contaminants in food products (various inorganic fertilizers, heavy metals and etc.)
• Household economic capacity is influencing
Diet can be used as a tool to evoke the positive/desirable biological responses of an organism aiming to maximize health and protection against diseases (chronic/non-communicable diseasesparticularly cancer) by mostly means of prevention.
4.Issue in late diagnosis of gastric cancer
Tulgaa L ; Ganchimeg D ; Chinzorig M ; Erkhembayar E ; Tegshjargal B ; Nasanjargal T ; Dashmaa A ; Bayar D ; Tsegmed S ; Bolor-Erdene T ; Otgonbayar I ; Batbold B
Mongolian Medical Sciences 2019;187(1):42-47
Introduction:
Gastric cancer is still one of the most leading causes of mortality in the world. The highest mortality rate of gastric cancer is estimated in Mongolia. South Korea and Japan, where leading the incidence of gastric cancer, mortality rates are observed in 51th and 31nd rank respectively. In Mongolia, gastric cancer is the second leading site, after liver cancer.
Goal:
We aimed to determine the cause of late diagnosis of gastric cancer and to evaluate supply of upper endoscopy devices and human resource for gastric cancer in the general hospital of provinces and districts.
Materials and Methods:
In this study, 84 patients suffering from gastric cancer (42 patients in III, IV TNM stage; 42 patients in I, II TNM stage)were investigated in National Cancer Center, Mongolia. A survey questionnaire which included age, gender, education, income, risk factors and clinical questions was detected from all patients. And we conducted study of supply of upper endoscopy devices and human resource for gastric cancer in general hospitals of from 21 provinces and general hospitals of 6 districts by questionnaire.
Results:
Seventy three(86.9%) patients were over 50 years old and the highest rates of gastric cancer were in group of 61-70 years (40.5%). From the results, the reason to visiting hospital was significantly different between two groups. 55.1% of patients suffering from early-stage gastric cancer were voluntarily diagnosed by upper endoscopy. In contrary, 55.8% of patients suffering from late-stage gastric cancer have visited the hospital due to worsening symptoms or dysphagia and vomiting. Factors such as age, gender, education, employment status and income had no significant effect on late diagnosis of gastric cancer. In totally 24(89%)general hospitals out of 27 had upper endoscopy devices and 22 (81.5%) hospitals had endoscopist. Although 75% of total general hospitals conduct
annual cancer screening, 64% of them do not perform the endoscopy in annual screening.
Conclusion
In our country, late diagnosis of gastric cancer is related to the attitudes of patients for preventing and screening disease. Therefore, it is important to improve the health education of the population and to develop healthy, right attitudes and practices. And the study revealed that general hospitals have insufficient for upper endoscopy devices and human resource.
5.Study on the risk factors of gastric cancer
Tulgaa L ; Ganchimeg D ; Enkhmyagmar D ; Tegshjargal B ; Nasanjargal T ; Ulziisaikhan B ; Dashmaa A ; Bayar D ; Bolor-Erdene T ; Erkhembayar E ; Chinzorig M ; Serjbayar G ; Batbold B
Mongolian Medical Sciences 2020;192(2):37-44
Introduction:
In 2018, a total of 901 new cases of gastric cancer were recorded, of which 64.8% in males and
34.2% in females. The incidence rate of gastric cancer was 28.5 per 100 000 population, which 38.2
for males and 19.2 for females.
Goal:
We aimed to investigate the associations between some risk factors and gastric cancer among the
Mongolian population.
Materials and Methods:
A case-control study was conducted between November 2017 and September 2019. We selected
120 cases from National cancer center of Mongolia who newly diagnosed gastric cancer. And 120
controls were selected by matching by sex, age and the place of residence. Informed consents
were obtained from all subjects. All subjects were personally interviewed with researchers used by a
structured questionnaire consisting of 86 questions. The SPSS 21 (version 16.0, SPSS Inc., Chicago,
IL, USA) software was used for all analyses.
Results:
The mean age was 59.2±11.4 (26-85) years. Habits of having dinner after 6.00 pm (OR 1.42, 95%CI
1.11-1.83, p=0.008), having leftover meals (OR 2.22, 95%CI 1.27-3.86, p=0.008), daily consumption
of tea with salt (OR 1.97, 95%CI 1.18-3.30, p=0.01), smoking on an empty stomach (OR 2.44,
95%CI 1.11-5.37, p=0.033), weekly consumption of ham and smoked meat (OR 1.5, 95%CI 1.17-
2.13, p=0.02), and consumption of fat grease (OR 2.09, 95%CI .03-4.24, p=0.038) were significantly
increased gastric cancer risk. In contrast, habit of eating at regular times (OR 0.43, 95%CI 0.25-0.73,
p=0.002), chewing thoroughly (OR 0.39, 95%CI 0.23-0.67, p=0.001), cooking meat thoroughly until
it’s tender (OR 0.48, 95%CI 0.25-0.97, p=0.047), daily consumption of vegetables (OR 0.45, 95%CI
0.27-0.76, p=0.003), and daily consumption of fruit juice (OR 0.36, 95%CI 0.15-0.85, p=0.026) were
significantly reduced gastric cancer risk. Furthermore, having first-degree relatives diagnosed with
gastric cancer had 2-3 fold higher increased risk of gastric cancer (parents OR 2.88, 95%CI 1.07-
7.78, p=0.038, sibling (OR 3.09, 95%CI 1.09-8.81, p=0.036). Also, previous records of the digestive
disease increased risk of gastric cancer (OR 3.65, 95%CI 2.10-6.35, p<0.0001).
Conclusion
Dietary habits, family history of gastric cancer and previous records of digestive disease were
associated with risk of gastric cancer. Thus, prevention effort could be focused on the population with
a family history of gastric cancer, changing bad dietary habit and screening precancerous disease of
gastric cancer.
6.The risk assessment of gastric cancer and precancerous condition using serum pepsinogen and H.pylori antibody test
Ganchimeg D ; Dashmaa A ; Tegshjargal B ; Batchimeg B ; Baljinnyam T ; Nasanjargal T ; Bayar D ; Batbold B ; Tulgaa L
Mongolian Medical Sciences 2021;197(3):33-39
Background:
The incidence of gastric cancer has been declining worldwide in recent years; on the
contrary, it has increased in the last decade in Mongolia. In Mongolia, over 80% of gastric cancer cases
are diagnosed in the late stage. We performed a gastroduodenoscopy for screening and histological
evaluation to diagnose gastric cancer. These methods are an effective diagnostic modality for gastric
diseases; however, invasive and cause discomfort, making it an undesirable procedure for patients.
Aims:
To determine serum PGs and H.pylori IgG in atrophic gastritis and gastric cancer patients and
evaluate the risk by ABC(D) classification.
Materials and Methods:
We selected 40 atrophic gastritis and 36 newly diagnosed gastric cancer
patients from National Cancer Center of Mongolia, before surgery and other therapies. Besides, we
enrolled population-based 38 healthy controls. Subjects of three groups were matched by age (±1)
and sex. Written informed consents were obtained from all subjects. The fasting blood samples were
collected and tested PGI, PGII, and H.Pylori IgG levels by enzyme-linked immunosorbent assay.
Also, PGI to PGII ratio (PGI/II ratio) was calculated. We classified subjects into four groups based on
ABC(D) classification. All statistical analyses were performed by SPSS (version 26.0, Chicago, IL,
USA) software.
Results:
Median age of the subjects was 62, 52.6% (n=60) were male. Proportions of family history
of gastric cancer and previous history of gastric disease were significantly higher in the gastric cancer
group compared with atrophic gastritis and healthy control groups (p<0.05, p<0.05). H.pylori was
positive in 67 (58.8%) subjects according to H.pylori IgG assay and there was no difference between
study groups. The serum PGI level and was significantly decreased in gastric cancer and atrophic
gastritis groups as compared to the healthy control (p<0.05, p<0.05). The PGI/II ratio was significantly
lower in the gastric cancer group compared with the healthy control (p<0.01). The optimal cut off
value of PGI was ≤35.25 ng/ml (AUC 64.3, 95% CI 51.3-77.2, p<0.05) for gastric cancer and PGI was
≤75.07 ng/ml (AUC 65.2, 95% CI 53.0-77.3, p<0.05) for atrophic gastritis. Also, the optimal cut off
value of PGI/II ratio was ≤5.27 (AUC 71.6, 95% CI 69.6-82.8, p<0.01) for gastric cancer and PGI/II
ratio was ≤6.25 (AUC 62.7, 95% CI 50.1-75.3, p<0.05) for atrophic gastritis. According to classification
of atrophic gastritis patients and healthy control, group D had higher proportion of atrophic gastritis
cases than group A, B and C (OR 5.04, 95% CI 1.13-22.50, p<0.05). According to classification of
gastric cancer patients and healthy control, groups C had higher proportion of gastric cancer cases
than group A, B and D (OR 6.19, 95% CI 1.04-36.78, p<0.05).
Conclusion
Our findings suggest that PGs level and H.pylori IgG may predict development of gastric
cancer and could identifying individuals at high risk of gastric cancer and precancerous lesions who
may need endoscopy.
7.The incidence of stomach and esophageal cancer in Mongolia: a data from 2009-2018
Tulgaa L ; Nasanjargal T ; Ulziisaikhan B ; Ganchimeg D ; Tegshjargal B ; Tsegmed S ; Batbold B
Mongolian Medical Sciences 2020;192(2):27-36
Introduction:
Cancer is a major public health issue both in Asia and in Mongolia. The most prevalent cancer related
deaths in Mongolia are registered for the stomach, esophagus and liver.
Purpose:
We aimed to investigate the incidence of stomach and esophageal cancer in Mongolian population.
Materials and Methods:
Epidemiologic data were collected from 2009 to 2018 through the oncology cabinet of all hospitals and
medical centers from all provinces, soums (the smallest unit of provinces) and major districts of the
capital city. The incidence of stomach and esophageal cancer was calculated by appropriate methods
and it was presented by ArcGIS Pro 9.2 software. A P-value of less than 0.05 was considered to be
statistically significant and based on two side hypotheses. All calculations were performed in the IBM
SPSS Statistics software. The study design in concordance with ethical guidelines was approved
by the Ethics Committee of Ministry of Health Mongolia. All clinical investigations were conducted
according to the principles laid down in the Declaration of Helsinki.
Results:
The incidence of esophageal cancer in last ten years (2009-2018) was 10.09 in 100000 populations
and the highest incidence were registered in Uvs (38.13), Bayan-Ulgii (24.15) and Zavkhan (18.18)
provinces, respectively. The incidence of stomach cancer was 20.33 in 100000 populations and the
highest incidences were registered in Uvs (53.01), Khovd (46.02) and Darkhan-Uul (40.50) provinces,
respectively.
Conclusion
1. Incidence rates for esophageal and stomach cancer are high among the Mongolian population.
In the last decade, the incidence of esophageal cancer had not decreased significantly, but it’s
constant.
In our study, the esophageal cancer incidence was 10.09 per 100’000 people, which includes
one of the high incidence rate countries according to the WHO classification. More than 10
aimags incidence rate of esophageal cancer was higher than the National average. Most of them have occurred in the western region of the country. Most of the Western, some of Khangai and
Eastern soums have had the highest incidence of esophageal cancer what we have shown on
the mapping.
2. The incidence rates of stomach cancer were registered as 20.33 per 100’000 people in the last
10 years at the national level. It has shown that according to the WHO classification, our country
is also one of the countries with the highest incidence of stomach cancer. The stomach cancer
incidence trend was increased in the last 10 decades. Therefore, some of aimag’s soums has
included the highest rate classification. In addition, some soums in the Western, Khangai, and
Eastern aimags had have a very high incidence of stomach cancer.
According to results in the above, the nationwide targeted prevention program is needed
especially where the highest incidence rates. Also there is a lack of cooperation between national
organizations to accurate registration of gastrointestinal cancer and to fight against these harmful
cancers.