1.A Case of Achieving Complete Remission with Combination of Sorafenib and Tegafur in Patients with Hepatocellular Carcinoma with Progression of Disease after Sorafenib Therapy.
Sang Youn HWANG ; Seon Mi LEE ; Jung Woo IM ; Ki Jeong JEON ; Sang Bu AHN ; Jin Young PARK ; Cheol Won CHOI ; Kwang Mo YANG
Journal of Liver Cancer 2017;17(1):88-93
Sorafenib is the only approved targeted agent as the first line systemic therapy for treatment of advanced hepatocellular carcinoma (HCC). However, the improvement of survival duration under 3 months is far from clinical satisfactory and most patients experience disease progression within 6 months after sorafenib therapy. Unfortunately, second line systemic therapy after treatment failure of sorafenib was not established and there were no clear guidelines for salvage treatment modalities. Recently, studies suggests that combination of sorafenib and single cytotoxic agent can be relatively effective and safe strategy that achieves promising rates of local and systemic control in advanced HCC patients. Based on above suggestions, we herein offer our experience of a case achieved complete remission by combination therapy of sorafenib and tegafur in the patient with progressed disease after sorafenib therapy.
Carcinoma, Hepatocellular*
;
Disease Progression
;
Humans
;
Salvage Therapy
;
Tegafur*
;
Treatment Failure
2.Clinical Pharmacokinetics of Tegafur Administered with Epirubicin and Cisplatin in Patients with Advanced Gastric Cancer.
Jin Hyung KANG ; Yoo Lim KIM ; Hea Kyoung CHO ; Eun Sook LEE ; Soo Jin CHA ; Young Sun HONG ; Kyung Shik LEE ; Hyo Jeong KUH
Cancer Research and Treatment 2003;35(3):224-231
PURPOSE: Tegafur, an oral prodrug of 5-fluorouracil (5-FU), has been used in the treatment of gastric cancers. UFT (tegafur + uracil) has been developed to enhance the efficacy of tegafur. This study was conducted to assess the pharmacokinetics (PK) of tegafur in gastric cancer patients given the ECU-E regimen (epirubicin, cisplatin, UFT-E, an enteric-coated formula of UFT). A preliminary evaluation of antitumor efficacy and toxicity of ECU-E regimen was also performed. MATERIALS AND METHODS: Of the 32 gastric cancer patients registered for the ECU-E regimen, 8 participated in the PK study. The plasma concentration of tegafur was determined using HPLC. RESULTS: Seven out of the 8 patients were evaluable for response after 2 cycles, and showed 3 partial responses, 1 stable disease and 3 progressive diseases. No major toxicities were observed. Plasma profiles of the tegafur after the first dose showed significant differences in the amount and rate of absorption, i.e., rapid absorption group vs. slow absorption group. The level of C(max) in the rapid absorption group was 1.8 fold higher, and the AUC(0-5h) 4 fold greater, than those in the slow absorption group, nonetheless, the steady state concentrations showed no significant difference. These data indicate that the different absorption rates may not affect the overall exposure to tegafur. The patients with low Cp(ss, peak) showed poor efficacy compared to those with high Cp(ss, peak), suggesting that the concentration of tegafur may be one of the pharmacodynamic determinants in patients administered with ECU-E. CONCLUSION: This study evaluated the pharmacokinetics of tegafur in gastric patients given the ECU-E regimen, and provides preliminary data on the relationship between the plasma tegafur level and the efficacy, which warrants further evaluation.
Absorption
;
Chromatography, High Pressure Liquid
;
Cisplatin*
;
Epirubicin*
;
Fluorouracil
;
Humans
;
Pharmacokinetics*
;
Plasma
;
Stomach Neoplasms*
;
Tegafur*
;
Uracil
3.A Case of Fixed Drug Eruption Induced by Tegafur-Uracil(TEGASIL).
Young Soo HEO ; Hae Jun SONG ; Chil Hwan OH
Korean Journal of Dermatology 2010;48(2):155-157
A mixture of tegafur and uracil (TEGASIL) is a common antineoplastic agent. Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil (5-FU); uracil slows the degradation of 5-FU by dihydropyrimidine dehydrogenase, which results in higher 5-FU concentrations in tumors. Mucocutaneous side effects induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, there have been no reports of fixed drug eruption associated with TEGASIL. We report here on a case of fixed drug eruption due to oral TEGASIL.
Dihydrouracil Dehydrogenase (NADP)
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Drug Eruptions
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Erythema
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Fluorouracil
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Hyperpigmentation
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Keratoderma, Palmoplantar
;
Tegafur
;
Uracil
4.Clearance of Actinic Keratosis Caused by the Prodrug of 5-Fluorouracil.
In Ho PARK ; Sang Min HWANG ; Sung Ku AN
Korean Journal of Dermatology 1999;37(10):1528-1531
Tegafur [1-(tetrahydro-2-furyl)-5-fluorouracil], the prodrug of 5-fluorouracil, is an anticancer agent. Several cutaneous reactions have been reported following systemic 5-fluorouracil for the treatment of malignancies. We report a patient with marked inflammation of the actinic keratosis following the use of tegafur for stomach carcinoma. The side-effect with 5-fluorouracil was beneficial as most actinic keratosis cleared following the inflammatory reaction. Dermatologists and oncologists should be aware of this potential side-effect, not only because it may become more prevalent but, most importantly, because it is not an allergic reaction to 5-fluorouracil but a dose-dependent response, and the chemotherapy may be continued in most patients.
Actins*
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Drug Therapy
;
Fluorouracil*
;
Humans
;
Hypersensitivity
;
Inflammation
;
Keratosis, Actinic*
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Stomach
;
Tegafur
5.Discoid Lupus Erythematosus-like Eruption Induced by Tegafur - Uracil (UFT).
Junghee YOON ; Soo Hong SEO ; Young Chul KYE ; Hyo Hyun AHN
Korean Journal of Dermatology 2010;48(11):1004-1007
The second-generation oral anticancer agent UFT is a combination of uracil, which has fluorouracil's (5-FU) degradation-inhibitory effect, and tegafur, which is slowly converted to 5-FU in vivo, and UFT shows a higher 5-FU concentration in the tumor tissues than is achieved by tegafur alone or with comparable doses of intravenous 5-FU. Mucocutaneous side reactions induced by UFT are rare and these include photosensitivity of the lichenoid and eczematous types, acral erythema, hyperpigmentation, palmoplantar keratoderma and scleroderma-like reactions, and discoid lupus erythematosus (DLE)-like eruption. However, there has been no report in the Korean medical literature on patients presenting with a DLE-like eruption associated with UFT. So, we report here a case of DLE-like eruption induced by oral UFT.
Erythema
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Fluorouracil
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Humans
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Hyperpigmentation
;
Keratoderma, Palmoplantar
;
Lupus Erythematosus, Discoid
;
Tegafur
;
Uracil
6.Acral Erythema and Hyperpigmentation Induced by Tegafur.
Seog Jun HA ; Sang Hee HAM ; Young Min PARK ; Sang Hyun CHO ; Baik Kee CHO
Korean Journal of Dermatology 1998;36(2):363-366
Tegafur is a fluoropyrimidine structurally similar to 5-fluorouracil, used in the treatment of advanced gastrointestinal neoplasms. Mucocutaneous side reactions induced by this agent are rare and include photosensitivity of lichenoid and eczematous types, acral erythema, hyperpigmentation and palmoplantar keratoderma. However, to our knowledge, there has been no report of concurrent development of eruptions of two types in a patient. We describe a female patient with breast cancer, presented with combined features of acral erythema and hyperpigmentation due to oral tegafur.
Breast Neoplasms
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Erythema*
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Female
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Fluorouracil
;
Gastrointestinal Neoplasms
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Humans
;
Hyperpigmentation*
;
Keratoderma, Palmoplantar
;
Tegafur*
7.Oxaliplatin and UFT, leucovorin combination chemotherapy in patients with advanced colorectal cancer.
Jin Hyang SHIN ; So Yeon KIM ; Chang Min WOO ; Young Sup KIM ; Ji Young KIM ; Jung Hyun SEO ; Wan Suk LEE ; Sung Hwa BAE ; Hun Mo RYOO ; Han Il LEE ; Im Hee SHIN ; Min Kyoung KIM ; Jae Lyun LEE ; Kyung Hee LEE ; Myung Soo HYUN
Korean Journal of Medicine 2004;67(1):58-64
BACKGROUND: UFT/oral leucovorin (LV) provided a safer, more convenient oral alternative to bolus i.v. 5-Fluorouracil/LV regimen for advanced colorectal cancer while producing equivalent survival. We evaluated the efficacy and safety of a combination of oxaliplatin and UFT/LV in patients with advanced colorectal cancer. METHODS: From January 1999 to December 2001, a total 28 patient with metastatic or relapsed colorectal cancer were enrolled in this study. Treatment was consisted of oxaliplatin 130 mg/m2 i.v. for 2 hours on day 1, and UFT 300 mg/m2 p.o. and LV 30 mg p.o. on day 1-21. Chemotherapy repeated every three weeks until disease progression. RESULTS: Of the 28 patients, 1 complete response and 10 partial responses were observed. The overall response rate was 39.3%. The estimated median time to progression and survival were 6.0 months and 18.2 months, respectively. Peripheral neuropathy was the most common adverse effect. But, peripheral neuropathy was mild (grade 1, 2) and reversible. From the 129 cycles analyzed, grade 3, 4 adverse effects were observed only 3% included neutropenia (1.5%), and thrombocytopenia (1.5%). There were no treatment-related deaths. CONCLUSION: This combination of oxaliplatin and UFT/oral leucovorin is active and feasible in patients with advanced colorectal cancer. The regimen deserve further evaluation in a phase III prospective study.
Colorectal Neoplasms*
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Disease Progression
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Drug Therapy
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Drug Therapy, Combination*
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Humans
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Leucovorin*
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Neutropenia
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Peripheral Nervous System Diseases
;
Tegafur
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Thrombocytopenia
;
Uracil
8.Influence factors on the entrapment of drugs in a novel proliposomes.
Acta Pharmaceutica Sinica 2006;41(12):1204-1207
AIMA new proliposomal technology was used to trap several drugs, such as tegafur, silymarin, cistanosides, oleanolic acid. And then these proliposomal characters were studied.
METHODSThese proliposomes formed liposomes after mixing with water. And then the liposomal morphology was determined by electron microscope, and the liposomal particle size determined by particle sizes instrument. The trap efficiency was determined by the column chromatography, and then the influence factors on the trap efficiency were investigated.
RESULTSThe liposomes looked round, some with multiply layers, the particle was small, and the xi potential was about - 30 mV. The trap efficiency changed with the partition coefficient and pH. When the partition coefficient and pH increased, the trap efficiency increased. Furthermore, the trap efficiency was not influenced by the molecular weight.
CONCLUSIONThis kind of liposomal technology trapped the drugs efficiently, and the lipophilic drugs were trapped more easily. Some Chinese traditional drugs could be trapped too.
Hydrogen-Ion Concentration ; Liposomes ; chemistry ; Oleanolic Acid ; administration & dosage ; Particle Size ; Silymarin ; administration & dosage ; Technology, Pharmaceutical ; Tegafur ; administration & dosage
9.Detailed Analysis of Chromosome Aberrations in Human Leukocyte Induced by Anti-malignant Tumor Agent (FT-207).
Yonsei Medical Journal 1978;19(1):7-15
The anticancer agent's FT-207, N1-(2'-tetrahydrofuryl)-5-fluorouracil, a derivative of 5FU (5-fluorouracil), induced chromosome damage to the human leukocyte was investigated. FT-207 inhibit mitosis and cause chromatid and chromosome breakage and chromatid exchange with 20 ug/ml for 48 to 72 hours of treatment. However, with 15 ug/ml for 72 hours only delayed spiralization was produced in some of the chromosomes in the same cells. The random distribution of chromosome breakage were observed and the effect of FT-207 on the chromosomes of human leukocytes were time dependent rather than concentration dependent. The comparision of the effect of mitomycin C on human leukocytes and the action of FT-207 at specific times during the cell cycle were discussed.
Cells, Cultured
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Chromosome Aberrations*
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Female
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Fluorouracil/analogs & derivatives*
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Human
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Leukocytes/drug effects
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Leukocytes/ultrastructure*
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Male
;
Mitotic Index/drug effects
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Tegafur/pharmacology*
;
Time Factors
10.Prospective Randomized Trial for Postoperative Adjuvant Chemotherapy in Gastric Cancer Patients without Serosal Invasion: Preliminary Report.
Yong Ho KIM ; Byung Sik KIM ; Chang Hwan LEE ; Wan Su KIM ; Jung Whan YOOK ; Sung Tae OH ; Kun Choon PARK
Journal of the Korean Gastric Cancer Association 2001;1(4):221-227
PURPOSE: We have carried out prospective randomized clinical trial to compare survival benefit and side effect among three postoperative adjuvant chemotherapeutic regimens in serosa-negative gastric cancer patients. MATENRIALS AND METHODS: Total 317 cases were recognized as serosa negative and randomized into three groups at operating room. Out of them, 172 cases were excluded because of various reasons and 135 cases were analyzed finally; Group A 36 cases, Group B 49 cases, Group C 50 cases. Group A were treated with intravenous FP combination therapy, group B with MF combination therapy and group C with oral UFT(R) (mixture of Tegafur and Uracil) for one year. The median follow-up period was 30 months. RESULTS: 88.9% of Group A, 83.7% of Group B and 90.4% of Group C received adequate chemotherapy. The complication rates of Group A (44.4%) was significantly higher than group B (20.4%) and group C (24.0%)(P<0.05). Most frequent complications were nausea and vomiting. The 3-year survival rates and disease-free survival rates were 92.2% and 89.9% respectively (Group A: 96.6%, 87.8%, B: 90.3%, 87.7%, C: 95.7%, 93.8%). There were no significant differences in survival rate and disease-free survival rate among the three groups (P>0.05). CONCLUSION: This study might suggest that the survival benefit of postoperative adjuvant chemotherapy for gastric Pseudomonas aeruginosa, and therefore it may be a useful adjunct tool for detection of Pseudomonas aeruginosa infection in combination with other conventional techniques.
Chemotherapy, Adjuvant*
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Disease-Free Survival
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Drug Therapy
;
Follow-Up Studies
;
Humans
;
Nausea
;
Operating Rooms
;
Prospective Studies*
;
Pseudomonas aeruginosa
;
Psychotherapy, Group
;
Serous Membrane
;
Stomach Neoplasms*
;
Survival Rate
;
Tegafur
;
Vomiting