No abstract available.
Technetium Tc 99m Disofenin*

No abstract available.
Humans ; Technetium Tc 99m Disofenin* ; Ultrasonography*

No abstract available.
Infant, Newborn ; Jaundice, Neonatal* ; Radionuclide Imaging* ; Technetium Tc 99m Disofenin*

PURPOSE: The authors investigated the ability of cardiac blood pool clearance rates(CBCR) of 99mTc-DiSiDA in the measure merit of functioning hepatocyte mass. MATERIALS AND METHODS: We measured the volume of Iobectomized liver after completion of postoperative scanning with CBCR of 99rnTc-DISIDA in 5 rabbits who the functional hepatic Iobectomy performed by ligation of hepatic artery, portal vein and biliary tracts. Regarding the measurement of CBCR of 99mTc-DISIDA, we set the time which was decreased to the half of the clearance amount of the cardiac radioactivity by hepatic extraction of 99mTc-DISIDA at the point of 50 sec after the renal peak of the radioactivity to prevent confusing with the blood dilution of the radioactivity, that have called DI-K50. RESULTS: The results were followed that the volumes of the functional hepatic Iobectomy in 5 rabbits were 25%, 25%, 41%, 52%, 75% and the residual functioning hepatocyte masses measured by CBCR of 99rnTc-DISIDA were preserved to 75. 1%, 70. 8%, 63. 0%, 52. 2%, 30. 8% respectively. CONCLUSION: we made decision that CBCR of 99rnTc-DISlDA was useful to evaluate the functioning hepatocyte mass.
Biliary Tract ; Hepatic Artery ; Hepatocytes* ; Ligation ; Liver ; Portal Vein ; Rabbits ; Radioactivity ; Technetium Tc 99m Disofenin*

Congential bile duct cysts, the so called "choledochal cysts" occur at all levels of the biliary tree and may be of saccular, diverticular, or fusiform configuration. There are 6 types of choledochal cysts proposed by todani et al based on roentgenologic and operative findings. This disease is usually diagnosed at the childhood or early adult life and predilection for orientals. Clinical manifestations are usually jaundice, right upper quadrant abdominal pain and abdominal mass. Here we are reporting a case of choledochal cyst, type IV-A diagnosed by abdominal ultrasonogram. 99mTc-DISIDA hepatobiliary scan and endoscopic retrograde cholangiopancreatogram.
Abdominal Pain ; Adult ; Biliary Tract ; Choledochal Cyst* ; Humans ; Jaundice ; Technetium Tc 99m Disofenin ; Ultrasonography

PURPOSE: This study examined 50 cases of laparoscopic cholecystectomy performed by a single inexperienced surgeon to determine the usefulness of a hepatobiliary scan with 99mTc-DISIDA as the contributing factor related to the conversion to an open cholecystectomy. METHODS: From July 2004 to June 2005, 34 patients, who underwent a laparoscopic cholecystectomy by an inexperienced surgeon, were evaluated. The effectiveness of a hepatobiliary scan with 99mTc-DISIDA as preoperative evaluation was also examined. The patients were divided into 3 groups according to the hepatobiliray scan findings: group A had normal findings, group B had decreased gallbladder contraction and group C had gallbladder nonvisualization. The patients' charts, age, gender, previous history of abdominal operation, preoperative laboratory data, preoperative ultrasound findings, pathologic findings, conversion rate to open cholecystectomy, surgical complication and hospital stay were reviewed. RESULTS: The mean age was 52.7 years and the male-to- female ratio was 1 : 1.3. All 34 were diagnosed with a gallbladder stone in the preoperative ultrasound. The number of patients in group A, B, and C was 11, 15, and 8, respectively. The conversion rate was 0%, 0%, and 37%, respectively. The mean length of hospital stay was 5.5, 5.5, and 8 days in group A, B and C, respectively. CONCLUSION: The conversion rate and hospital stay decreased in laparoscopic cholecystectomy as the surgical experience increased with the increasing number of cases. However, the conversion rate was still high in the inexperienced surgeon. A preoperative hepatobiliary scan with 99mTc- DISIDA allows inexperienced surgeons to predict the thickening of the gallbladder wall, inflammation and the anatomic conditions of the gallbladder, and discuss the high risk of conversion preoperatively.
Cholecystectomy ; Cholecystectomy, Laparoscopic* ; Cholecystitis ; Female ; Gallbladder ; Humans ; Inflammation ; Length of Stay ; Technetium Tc 99m Disofenin ; Ultrasonography

Recently, several reports of extrahepatic hepatocellular carcinoma metastasis demonstrated by technetium-99mTc-IDAs scan have shown that 99mTc-IDAs can be used to detect extrahepatic metastasis in hepatocellular carcinoma. We report here a case of hepatocellular carcinoma with pulmonary nodules that were demonstrated as metastasis in nature by the use of the 99mTc-DISIDA. The findings in this case and several reports reviewed here suggest that the 99mTc-DISIDA scan may be a useful diagnostic agent that can detect the extrahepatic metastasis of hepatocellular carcinoma and stage the disease. But more clinical study in needed to establish the position of 99mTc-DISIDA in the field of diagnosis of extrahepatic hepatocellular carcinoma.
Carcinoma, Hepatocellular* ; Clinical Study ; Diagnosis ; Lung* ; Neoplasm Metastasis ; Technetium Tc 99m Disofenin

PURPOSE: To determine the significance of anomalous position of the gallbladder. MATERIALS AND METHODS: Sixteen patients with anomalous position of the gallbladder were evaluated for analysis. The diagnosis was confirmed by ultrasonography(15 patients) and oral cholecystography(1patient). Among those, six patients underwent CT scan and a patient had 99mTc-DISIDA scan. The images were analysed with respect to the location of the GB and configuration and associated abnormality of the liver and hepatobiliary systems. Medical records of each patient were also reviewed. RESULTS: Among 16 patients having an anomalous position of the gallbladder, nine had retrodisplaced gallbladder, four had left-sided gallbaldder, two had suprahepatic gallbladder, and one had floating gallbladder. Except for one patient, fifteen had abnormality in the liver such as focal atrophic or hypoplastic change and liver cirrhosis. Intrahepatic stones were demonstrated in 6 patients. CONCLUSION: Our results showed that anomalous position of the gallbladder was commonly associated with atrophy or hypoplasia of the liver rather than congenital in origin. The possiblity of an anomalous location of gallbladder should be kept in mind when GB is not in its normal location.
Atrophy ; Diagnosis ; Gallbladder* ; Humans ; Liver ; Liver Cirrhosis ; Medical Records ; Technetium Tc 99m Disofenin ; Tomography, X-Ray Computed

Crigler-Najjar syndrome is a rare inherited disease associated with unconjugated hyperbilirubinemia. It is inherited via an autosomal recessive pattern and is caused by mutation in one of the five exons of the bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) gene. The synthesis of inactive isoforms of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (B-UGT) results in unconjugated hyperbilirubinemia. A 13-year-old boy with jaundice for 4 months was admitted to our hospital. He had unconjugated hyperbilirubinemia with no evidence of infection, hemolysis, or structural abnormalities on abdominal ultrasonography or 99mTc-DISIDA scan. The authors identified a missense mutation of Tyr486Asp in the fifth exon of the UGT1A1 gene and diagnosed the patient with Crigler-Najjar syndrome type II. This is the first reported case of Crigler-Najjar syndrome in a Korean child, and it is also the first reported case of a genetic mutation leading to Crigler-Najjar syndrome in Korea.
Adolescent ; Bilirubin ; Child ; Crigler-Najjar Syndrome ; Exons ; Glucuronosyltransferase ; Hemolysis ; Humans ; Hyperbilirubinemia ; Jaundice ; Mutation, Missense ; Protein Isoforms ; Technetium Tc 99m Disofenin

Crigler-Najjar syndrome is a rare inherited disease associated with unconjugated hyperbilirubinemia. It is inherited via an autosomal recessive pattern and is caused by mutation in one of the five exons of the bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (UGT1A1) gene. The synthesis of inactive isoforms of bilirubin uridine-diphosphoglucuronate glucuronosyltransferase (B-UGT) results in unconjugated hyperbilirubinemia. A 13-year-old boy with jaundice for 4 months was admitted to our hospital. He had unconjugated hyperbilirubinemia with no evidence of infection, hemolysis, or structural abnormalities on abdominal ultrasonography or 99mTc-DISIDA scan. The authors identified a missense mutation of Tyr486Asp in the fifth exon of the UGT1A1 gene and diagnosed the patient with Crigler-Najjar syndrome type II. This is the first reported case of Crigler-Najjar syndrome in a Korean child, and it is also the first reported case of a genetic mutation leading to Crigler-Najjar syndrome in Korea.
Adolescent ; Bilirubin ; Child ; Crigler-Najjar Syndrome ; Exons ; Glucuronosyltransferase ; Hemolysis ; Humans ; Hyperbilirubinemia ; Jaundice ; Mutation, Missense ; Protein Isoforms ; Technetium Tc 99m Disofenin