CNS malignant astrocytoma has a descending frequency of
occurrence according to site; moving from intracranial to
cervical-medullary, thoracic, lumbar and extremely rare in
the conus medullaris. IMSC glioblastoma are rare and de
novo conus medullaris GBM is an extreme rarity. The
duration of symptoms is short and the neurological & clinical
deterioration are rapid. Despite aggressive treatment via
surgery and radiotherapy IMSC & conus GBM still carry a
grim and fatal prognosis. This is a strong motivation for
developing new treatment strategy. New treatment modality
like Temozolomide & gene therapy is currently in under studyand long term result is under study and review.