We performed a clinical observation on the 208 cases of infectious hepatitis who were cared at the pediatric department of Fatima Hospital from July, 1, 1970, to June, 30, 1977, and obtained the following results. 1. The ratio of infectious hepatitis to the total number of in-patients was 3.25 in average. 2. There was no significant difference in seasonal incidence except spring when the incidence was lower than the other seasons. 3. The age-group of 3~8 years old occupied 69% of the total cases and sex incidence revealed mali predominence with the ratio about 2:1. 4. The frequently observed clinical manifestations included ; Anorexia(71%)Nausea/Vomiting(65%), Tiredness(53%), Dark urine(59%), Abdominal pain(54%), Fever(45%), Jaundice(75%), Hepatomegaly(71%), Tenderness on upper adbomen(40%), and Palpable spleen(12.3%). 5. In the most of the cases the hematologic findings were with-in normal limit. 6. Bilirubinuria was observed in about 65% of the tested cases during the first 2 weeks of the illness and urinary urobilinogen was decreased during the second week of the illness. 7. In the majority of the cases the serum bilirubin reached peak during the second week of the illness and ranged 2~15mg%. And by the end of the 4th week illness, they returned to less than 2mg% in the 85%of the tested cases. 8. SGOT and SGPT reached peak during the first week of the illness and by the end of 4th week, they returned to less than 100 unit in the most the tested cases. And the values of SGOTwere higher than SGOT throughout the course of the illness. 9. The electrophoresis of the serum protein revealed as follow ; 1-globulin decreased slightly and -globulin in creased. 10. We experienced 30 cases (14.4%) of anicteric hepatitis. 11. ABHg was positive in 2(3.8%) of the 52 tested cases. 12. 10 of the 208 cases complicated hepatic coma and 10 of them expired and 3 of them dischared without clinical improvement.
Alanine Transaminase ; Aspartate Aminotransferases ; Bilirubin ; Child* ; Electrophoresis ; Hepatic Encephalopathy ; Hepatitis ; Hepatitis A* ; Humans ; Incidence ; Mali ; Seasons ; Urobilinogen

BACKGROUND/AIMS: The aim was to compare the insulin sensitivity and secretion index of pregnant Korean women with normal glucose tolerance (NGT), gestational impaired glucose tolerance (GIGT; only one abnormal value according to the Carpenter and Coustan criteria), and gestational diabetes mellitus (GDM). METHODS: A cross-sectional study was performed with 1,163 pregnant women with positive (1-hour plasma glucose > or = 7.2 mmol/L) in a 50-g oral glucose challenge test (OGCT). The 100-g oral glucose tolerance test (OGTT) was used to stratify the participants into three groups: NGT (n = 588), GIGT (n = 294), and GDM (n = 281). RESULTS: The GDM group had higher homeostasis model assessment of insulin resistance and lower insulin sensitivity index (ISOGTT), quantitative insulin sensitivity check index, homeostasis model assessment for estimation of index beta-cell secretion (HOMA-B), first and second phase insulin secretion, and insulin secretion-sensitivity index (ISSI) than the NGT group (p < or = 0.001 for all). Moreover, the GIGT group had lower ISOGTT, HOMA-B, first and second phase insulin secretion, and ISSI than the NGT group (p < 0.001 for all). Among the GIGT subjects, the 1-hour plasma glucose abnormal levels group showed significantly greater weight gain during pregnancy and higher values in the 50-g OGCT than the other two groups. Moreover, the 1-hour and 2-hour abnormal levels groups had poorer insulin secretion status than the 3-hour abnormal levels group. CONCLUSIONS: Korean women with GDM show impairments of both insulin secretion and insulin sensitivity. In addition, GIGT is associated with both beta-cell dysfunction and insulin resistance.
Adult ; Cross-Sectional Studies ; Diabetes, Gestational/*metabolism ; Female ; Glucose Tolerance Test ; Humans ; Insulin/*secretion ; *Insulin Resistance ; Pregnancy