1.Analysis of Utilization of Human Serum Albumin in a Hospital in the First Quarter of 2006
Hua LU ; Taotao LIU ; Shuangyi TANG
China Pharmacy 2001;0(08):-
OBJECTIVE:To evaluate the utilization of human serum albumin in a hospital.METHODS:The utilization of human serum albumin in a hospital in the first quarter of 2006 was reviewed analytically using hospital computer database system.RESULTS:Human serum albumin was used in 55 departments for 17 categories of diseases,mainly for critical patients,with a common individual consumption quantity ranged from 10 g to 20 g.Most(51.10%) of the patients used this drug on account of hypoproteinemia,and most of them had a baseline serum albumin level at 21~30 g?L-1 before using human serum albumin.CONCLUSION:Human serum albumin was used extensively in the hospital.But its use is sometimes irrational because some physicians didn't familiarize the real indications for using human albumin,which should be intervened urgently.
2.Estimation of Cystatin C as a Marker of Renal Function to Predict Serum Trough Concentrations of Vancomycin
Yimei LIAO ; Taotao LIU ; Daohai CHENG ; Hua LU
Herald of Medicine 2015;(6):730-732
Objective To investigate the clinical efficiency of serum cystatin C as a marker of renal function to predict serum trough concentrations of vancomycin. Methods Data on trough concentrations of vancomycin(Cmea ),serum creatinine (Scr)concentrations,cystatin C( Cys C) concentrations were collected from 81 hospitalized patients who received vancomycin therapy. Predicted vancomycin trough concentrations(Cpre )were calculated based on Scr or Cys C concentrations associating with Bayesian forecasting method through NONMEM software. Finally,the correlations and distinctions between Cpre and Cmea were comparatively analyzed. Results There were both correlation between Cpre and Cmea in relation to Scr or Cys C(r = 0. 678,P<0. 01;r=0. 727,P<0. 01). Besides,the errors of mean predictive error(ME),mean absolute error(MAE)and root-mean-square error(RMSE)for Scr was - 5. 79,6. 86,9. 86 μg · mL-1 , respectively, where as the errors for Cys C was - 0. 82,5. 42, 7. 74 μg·mL-1 ,respectively. Conclusion Cystatin C is a good marker of renal function available for predicting serum vancomycin concentrations.
3.The effect of underwater partial body-weight-supported treadmill training on hindlimb locomotor function recovery and on the expression of brain-derived neurotrophic factor and neurotrophin-3 in rats after spinal cord injury
Haiyan LIN ; Wenzhan TU ; Taotao TAO ; Huaixia LIU ; Bo CHENG ; Songhe JIANG ; Lu JIKE
Chinese Journal of Physical Medicine and Rehabilitation 2010;32(12):887-891
Objective To observe the efficacy of underwater partial body-weight-supported treadmill training in repairing spinal cord injury (SCI) and its relationship with spinal nerve plasticity. Methods A total of 40 Sprague-Dawley rats were randomly divided into five groups: a sham model group, a model control group, an underwater training group, a partial body-weight-supported treadmill training (PBWSTT) group and an underwater PBWSTT group. A rat model of SCI was induced by contusion of the T10 segment with a Multicenter Animal Spinal Cord Injury Study (MASCIS) impactor. One week post-operation, different rehabilitation strategies, such as free exercise in water, BWSTT and underwater PBWSTT, were administered to the rats in the underwater training groups for 8 weeks.Those in the sham model group and model control group were given no training. The Basso, Beattie and Bresnahan (BBB) locomotor rating scale and a climbing test were used to evaluate the recovery of hindlimb locomotor function.The expression of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 (NT-3) in the spinal cords was detected with immunohistochemical methods. Results Nine weeks post-operation, hindlimb locomotor function had improved significantly more in the underwater PBWSTT group than in underwater training group or the BWSTT group.The expression of BDNF in the 3 training groups was significantly higher than in the model control group, though there was no significant difference among the 3 training groups. The expression of NT-3 in the underwater PBWSTT group increased more significantly than in the BWSTT group, however there was no significant difference between the underwater PBWSTT group and the underwater training group. Conclusion Underwater PBWSTT can promote the recovery of hindlimb locomotor function in rats after SCI, probably through increasing the expression of BDNF and NT-3 and thus promoting neural plasticity in the spinal cord.
4.Population pharmacokinetics of vancomycin and prediction of pharmacodynamics in the Chinese people.
Xiaorongl HE ; Zhihe LIU ; Shuangmin JI ; Taotao LIU ; Liang LI ; Tianyan ZHOU ; Wei LU
Acta Pharmaceutica Sinica 2014;49(11):1528-35
Population pharmacokinetics of vancomycin (VAN) in the Chinese patients was described by using nonlinear mixed-effects modeling (NONMEM). 619 VAN serum concentrations data from 260 patients including 177 males and 83 females were collected separately from two centers. A one-compartment model was used to describe this sparse data. No significant difference was observed between two center datasets by introducing SID covariate. The final model was as CL= (θ (base0+ θ(max) x(1 -e(-θ(Age)(Age/72) and V = θ x θ (Age)(Age/72). The creatinine clearance (CL(Cr)) and Age were identified as the most significant covariate in the final model. Typical values of clearance (CL) and volume of distribution (V) in the final model were 2.91 L x h(-1) and 54.76 L, respectively. Internal model validation by Bootstrap and NPDE were performed to evaluate the robustness and prediction of the final model. The median and 95% confidence intervals for the final model parameters were based on 1000 Bootstraps. External model evaluation was conducted using an independent dataset that consisted of 34 patients to predict model performance. Pharmacodynamic assessment for VAN by AUC (0-24 h) to MIC ratios of over 400 was considered to be the best to predict treatment outcomes for patients. AUC (0-24 h) was calculated by clearance based on the above population model. The results indicate that the conventional dosing regimen probably being suboptimal concentrations in aged patients. The approach via population pharmacokinetic of VAN combined with the relationship of MIC, Age, CL(Cr) and AUC(0-24 h)/MIC can predict the rational dose for attaining efficacy.
5.Surface electromyography signals from neck muscles during different craniocervical postures in a lateral recumbent position
Fang ZHANG ; Huaixia LIU ; Junyan LU ; Taotao TAO ; Bo CHENG ; Songhe JIANG
Chinese Journal of Physical Medicine and Rehabilitation 2010;32(5):363-365
Objective To survey cervical myoelectric signals during craniocervical flexion, neutral and extension postures, and to explore the evidence that proper head position can alleviate cervical muscle fatigue in a lateral recumbent position. Methods Surface electromyography (sEMG) signals were detected from the sternocleidomastoid, upper trapezius and erector spinae muscles of 30 young subjects bilaterally during craniocervical flexion,neutral and extension postures in the left lateral recumbent position. The integrated trace area (IEMG) and median frequency (MF) were estimated. Results The average IEMG of the sternocleidomastoid muscles was significantly lower in flexion than in extension bilaterally. The average IEMG of the erector spinae muscles was lower in extension than in flexion bilaterally, and the difference was again significant. The IEMGs of the upper trapezius muscle showed no significant difference on average in the three postures bilaterally. There was no significant MF difference in any of the muscles. Conclusions The muscles in the cervical back were less activated during craniocervical extension in a lateral recumbent position. A little cranicocervical extension is optimal while resting in a lateral recumbent position.
6.Visual analysis of nursing research on nasopharyngeal carcinoma patients undergoing radiotherapy based on CiteSpace
Xia WAN ; Taotao LU ; Wen ZHANG
Chinese Journal of Modern Nursing 2021;27(34):4715-4721
Objective:To conduct visual analysis of relevant literature on the nursing of patients with nasopharyngeal carcinoma radiotherapy, so as to provide a reference for the nursing of patients with nasopharyngeal carcinoma radiotherapy.Methods:The relevant research in China National Knowledge Infrastructure (CNKI) and Wanfang Data was searched, and the search time limit was from the establishment of the database to June 30, 2021. The volume of publications, authors, institutions, keywords and hot words were visualized in bibliometric analysis with the CiteSpace and Prism software.Results:A total of 450 relevant articles were screened out, and the total number of publications was on the rise. Research institutions in Guangxi was in an advantageous position in research, and there was still a lack of cooperation among different institutions. Current research hotspots in nursing care of patients with nasopharyngeal carcinoma undergoing radiotherapy revolved around formulating standardized nursing service procedures, nursing care for complications after radiotherapy, and providing complete comprehensive nursing interventions.Conclusions:Nursing care of patients undergoing radiotherapy for nasopharyngeal carcinoma has received continuous attention, and more and more innovative nursing methods and advanced nursing models have been applied to clinical practice. It is necessary to strengthen the construction of team collaboration network and conduct in-depth research on the comprehensive nursing management model.
7.Effect of Danzhi Jiangtang Capsule Combined with Atorvastatin on Intima-media Thickness in Diabetes Patients without Hypertension
Zhaohui FANG ; Jindong ZHAO ; Jinping WANG ; Yunfei NIU ; Yiqiong SHU ; Aihong YUAN ; Qian WU ; Qingyun FAN ; Jian LIU ; Taotao BAO ; Yuan LUO ; Ruimin LU ; Chenglin GUO ; Ting JIANG ; Liqun CUI ; Hui YANG
World Science and Technology-Modernization of Traditional Chinese Medicine 2013;(5):884-890
This study was aimed to observe the curative effect and safety of Danzhi Jiangtang Capsule ( DJC ) combined with atorvastatin on carotid artery intima-media thickness (IMT) in diabetes patients without hyper-tension . A total of 196 diabetes patients without hypertension with incrassate carotid artery IMT were randomly divided into the control group ( 98 cases ) and the treatment group ( 98 cases ) . The conventional diabetes thera-py was given to both groups . The atorvastatin of 20 mg/night was given to the control group . And the atorvas-tatin 20 mg/night added with DJC 9 . 0 g/night were given to the treatment group . The treatment course was
12 months . Carotid artery IMT , carotid atherosclerotic plaque area , FPG , FIns , HOMA-IR , HbA1c , blood lipids , hepatorenal function and etc . were examined before and after the treatment respectively . The results showed that there was a significant positive correlation between carotid artery IMT and FIns , HOMA-IR , HbAlc , LDL-C . After 12-month treatment , the total effectiveness is 85 . 87% in the treatment group . And there was significant difference compared with the control group ( P < 0 . 05 ) . The levels of FPG , FIns , HOMA-IR , HbAlc of the treatment group had no difference compared with the control group . Compared with the control group, TC and LDL-C of the treatment group was obviously decreased (P < 0.05). And HDL-C was significantly increased ( P < 0 . 05 ) . The carotid artery IMT of the treatment group decreased from ( 0 . 11 ±0 . 01 ) cm to ( 0 . 08 ± 0 . 01 ) cm . And compared with the control group , there was statistical significance ( P <0 . 05 ) . The carotid atherosclerotic plaque area of 58 cases in the treatment group decreased from ( 0 . 37 ±0.56) cm2 to (0.21 ± 0.25) cm2. However, there was no statistical significance compared to the control group. There were 5 adverse events in the control group and 9 adverse events in the treatment group . And there was no difference between two groups. It was concluded that DJC combined with atorvastatin can regulate lipid metabolism and reduce carotid artery IMT .
8.Influence Factors of the Thrombectomy Effects for Mechanical Thrombectomy Devices
Licheng LU ; Xuelian GU ; Taotao WANG
Journal of Medical Biomechanics 2019;34(3):E289-E294
Objective To investigate the influence of thrombus entrance shape, suction rate and blood flow velocity on thrombus aspiration of rotary cutting and suctioned thrombectomy devices, so as to provide theoretical support for the design and optimization of such devices. Methods Three models with different thrombus entrance shapes (‘L’-style, ‘8’-style and ‘0’-style) were established to study the influence of thrombus entrance shape on the thrombectomy; different suction rates (75, 100, 125, 150 mL/min) and different blood flow velocities (0-10 cm/s, at interval of 1 cm/s) were set to discuss how the suction rate and blood flow velocity affected the thrombectomy based on ‘8’-style thrombus entrance. Results The thrombus could not be aspirated evenly in ‘L’-style model, and there was no significantly difference in aspiration between ‘8’ -style model and ‘0’-style model. But the ‘8’-style model was better than ‘0’-style model in lateral thrombus suction. The suction rate that was greater than 100 mL/min provided a limited effect on improvement of thrombectomy effect. The best suction effect was reached when blood flow velocity was less than 1 cm/s, and the effect of thrombectomy was decreasing gradually with blood flow velocity increasing. Conclusions The thrombus entrance shape, suction rate and blood flow velocity had a great impact on thrombectomy greatly. A wide and short thrombus entrance shape, an appropriate increase of suction rate and decrease of blood flow velocity would contribute significantly to the improvement of thrombectomy effect. These results can be used as guidance for the optimal design of rotary cutting and suctioned thrombectomy devices.
9.Analysis of clinical value of serum inflammatory factors combined with pulmonary function index in identification of severe mycoplasma pneumonia in children
Jinying LU ; Taotao CHANG ; Jingjing ZHANG ; Lijuan LIU ; Ping YAN ; Zhanru YIN
Journal of Clinical Medicine in Practice 2024;28(6):65-68,73
Objective To investigate the clinical value of serum interleukin-6(IL-6)and inter-leukin-8(IL-8)levels in combination with pulmonary function indicators in identifying severe Myco-plasma pneumoniae pneumonia(MPP)in children.Methods A total of 102 children with severe MPP were selected as the study subjects(severe group),and another 102 children with mild MPP treated during the same period were selected as the mild group.The serum levels of IL-6,IL-8 as well as forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1 percent-age of predicted(FEV1%pred)and the ratio of FEV1 to FVC at the time of admission of children in each group were compared.Results The serum levels of IL-6 and IL-8 in the severe group were sig-nificantly higher than those in the mild group,while the FVC,FEV,%pred,and FEV1/FVC%were significantly lower than those in the mild group(P<0.05).The serum levels of IL-6 and IL-8 were negatively correlated with FVC,FEV1%pred and FEV1/FVC%(P<0.05).The area under the curve(AUC)for assessing the severity of MPP for IL-6,IL-8,FVC,FEV1%pred and FEV1/FVC%was 0.894(0.849 to 0.939),0.842(0.787 to 0.897),0.896(0.851 to 0.942),0.787(0.725 to 0.849)and 0.744(0.676 to 0.812),respectively.The AUC for the combined assessment of the above five parameters was 0.985(0.973 to 0.997).Conclusion Serum IL-6,IL-8 and pulmonary function indicators can reflect the severity of MPP in children.Their combined detection can be used to differentiate between mild and severe MPP in children early and timely.
10.Analysis of clinical value of serum inflammatory factors combined with pulmonary function index in identification of severe mycoplasma pneumonia in children
Jinying LU ; Taotao CHANG ; Jingjing ZHANG ; Lijuan LIU ; Ping YAN ; Zhanru YIN
Journal of Clinical Medicine in Practice 2024;28(6):65-68,73
Objective To investigate the clinical value of serum interleukin-6(IL-6)and inter-leukin-8(IL-8)levels in combination with pulmonary function indicators in identifying severe Myco-plasma pneumoniae pneumonia(MPP)in children.Methods A total of 102 children with severe MPP were selected as the study subjects(severe group),and another 102 children with mild MPP treated during the same period were selected as the mild group.The serum levels of IL-6,IL-8 as well as forced vital capacity(FVC),forced expiratory volume in one second(FEV1),FEV1 percent-age of predicted(FEV1%pred)and the ratio of FEV1 to FVC at the time of admission of children in each group were compared.Results The serum levels of IL-6 and IL-8 in the severe group were sig-nificantly higher than those in the mild group,while the FVC,FEV,%pred,and FEV1/FVC%were significantly lower than those in the mild group(P<0.05).The serum levels of IL-6 and IL-8 were negatively correlated with FVC,FEV1%pred and FEV1/FVC%(P<0.05).The area under the curve(AUC)for assessing the severity of MPP for IL-6,IL-8,FVC,FEV1%pred and FEV1/FVC%was 0.894(0.849 to 0.939),0.842(0.787 to 0.897),0.896(0.851 to 0.942),0.787(0.725 to 0.849)and 0.744(0.676 to 0.812),respectively.The AUC for the combined assessment of the above five parameters was 0.985(0.973 to 0.997).Conclusion Serum IL-6,IL-8 and pulmonary function indicators can reflect the severity of MPP in children.Their combined detection can be used to differentiate between mild and severe MPP in children early and timely.