Objective? To investigate the status of compassion fatigue, work stress and resilience of ICU nurses, and analyze the influencing factors of compassion fatigue. Methods? By convenience sampling method, 117 ICU nurses from two Class Ⅲ Grade A hospitals in He'nan Province were selected in February, 2018. The nurses were investigated with general information questionnaire, Chinese version of Compassion Fatigue Short Scale, Chinese version of Work Stressors Scale for Nurses and Chinese version of Connor-Davidson Resilience Scale (CD-RISC). The influencing factors of compassion fatigue among ICU nurses were analyzed by single factor analysis, Pearson correlation analysis and multiple linear regression analysis. Results? A total of 109 valid questionnaires were collected. The scores of compassion fatigue, work stress and resilience of ICU nurses were (48.62±12.24), (90.12±15.64), (42.77±13.54) respectively. Pearson correlation analysis showed that compassion fatigue was positively correlated with work stress and negatively correlated with resilience (P＜0.05). Multivariate linear regression analysis showed that resilience of ICU nurses was the influencing factor of compassion fatigue (P＜ 0.01). Conclusions? The level of compassion fatigue of ICU nurses is affected by their job stress and psychological resilience. We should pay more attention on the compassion fatigue of nurses with high job stress and low level of psychological resilience.

Objective To investigate the intervention effects and mechanism of icariin on prostate cancer based on network pharmacology and animal experiments.Methods The targets of icariin were predicted using the SwissTargetPrediction database.Protein-protein interaction networks were constructed with the String database,and core targets were screened using Cytoscape 3.9.1.GO and KEGG enrichment analysis on core targets were conducted with the Metascape database to predict the mechanism of action.A PC-3 tumor-bearing mouse model of prostate cancer was established to observe the inhibitory effects of icariin alone and in combination with paclitaxel on tumor growth.Results Network pharmacology predictions suggested that icariin has potential therapeutic effects on prostate cancer,with core targets potentially including serine/threonine kinase 1(AKT1),B-cell lymphoma-2(BCL2),epidermal growth factor receptor(EGFR),heat shock protein 90 alpha family class A member 1(HSP90AA1),heat shock protein 90 alpha family class B member 1(HSP90AB1),nuclear factor kappa B subunit 1(NF-κB1),tumor protein p53,etc.Animal experiments found that compared with the model control group,the tumor volume growth in the icariin group and the paclitaxel group was significantly inhibited,and the serum tumor necrosis factor content was significantly reduced,while testosterone levels did not change significantly.Both groups significantly downregulated the mRNA expression of Notch1,Jagged1 and Hes1(P<0.05),with the combined treatment group showing a more significant inhibitory effect.Conclusions Both network pharmacology and animal experimental results confirmed that icariin has a significant inhibitory effect on prostate cancer.One of the mechanisms of its anti-tumor effects may be the significant inhibition of the activated Notch signaling pathway in tumors.