There is a strong support for a role played by adiponectin in the function of ovary and placenta.There is evidence of direct effects of adiponectin on the late stages of folliculogenesis,and additive interactions of adiponectin with insulin and gonadotropins in inducing periovulatory changes in ovarian follicles.Adiponectin has demonstrated a potential effect on ovarian function as well as a possible effect on the formation of placenta,via multiple mechanisms,providing new strategies for the etiology investigation,prevention and treatment of reproductive and related metabolic diseases.

Polycystic ovary syndrome (PCOS)is the most common cause of anovulatory infertility in women of reproductive age, exerting significant impacts on glucose and lipid metabolism, cardiovascular and endometrial deseases, as well as breast, skin, bone, and psychology fields. As a complex, multi-system of endocrine and metabolic disease, PCOS would be recognized as a component of metabolic syndrome in an overall consideration. The clinical treatment of PCOS is expected to turn simply regulating menstruation and ovulation adjustment into the combination of insulin resistance improvement with antihyperandrogen and ovulation treatment comprehensively.

Clostridiodes difficile(C.difficile)is the most common causative agent of antibiotic-associated diarrhea(ADD)in the world. In recent years,with the emergence of highly resistant and virulent strains,the outbreaks of C.difficile infection have occurred around the world. The incidence,recurrence and mortality of C.difficile infection are on the rise worldwide,and bring great challenges to clinical treatment. Pathogenic strains mainly produce two homologous glycosylation toxins A and B,which can cause symptoms ranging from diarrhea to highly lethal toxic megacolon. In view of the malignant consequences caused by C.difficile infection,disease prevention is still an important way worth exploring. Until now there is no approved vaccine against C.difficile. Therefore,this review assessed the status and challenge of clinical trials of vaccine research for C.difficile.

ObjectiveTo study the rehabilitation for perimenopausal women with stress urinary incontinence.Methods60 perim enopausal women with stress urinary incontinence were randomly divided into groups A, B and C, 20 cases in each group. Group A for pelvic floor exercises, or Kegel training; group B received estrogen in addition; group C received low-frequency electrical stimulation and biofeedback in addition.ResultsUrinary incontinence volume and Kupperman score was positively correlated(r=0.752, P<0.01). Kupperman scores in groups A, B and C were significantly lower(P<0.01) 1 month, 3 months after treatment than before treatment. There was no statistical difference between group A and Group B at 1 month after treatment. Kupperman scores in Group C was significantly lower(P<0.01), and reduced further 3 months after treatment(P<0.01). The amount of urinary incontinence in groups A, B and C were significantly lower 1 month, 3 months after treatment than before treatment(P<0.01). There was no significant difference in urinary volume between group A and group B 1 month and 3 months (P>0.05). The urinary incontinence was significantly lower between group C and groups A, B 1 month, 3 months after treatment (P<0.01).ConclusionThe pelvic floor exercise, low-frequency electrical stimulation and biofeedback therapy can significantly reduce perimenopausal symptoms of stress urinary incontinence.

Objective To solve the problem of continuous augmentation of blood drawing quantity along with the increases of examination item, as well as the problem that patient identifies the lab test with difficulty because of the doctor's handwriting is always illegible. Methods The author introduced data -base management for information technology to increase structured data information and reasonably prepare the process structure. Results The implementation can avoid the repetition of blood drawing, reduce the blood using quantity and the painfulness of patient, and it also provides the standard printing lab test report, as well as the information of the blood drawing time and report taking time. Conclusion The technical improvement of the out -patient blood information system realizes the blood sample sharing and blood quantity reduction, facilitates the patient and blood drawing operator.

Animals ; Antioxidants ; pharmacology ; Cerebellum ; cytology ; Dietary Supplements ; Drugs, Chinese Herbal ; chemistry ; Fruit ; chemistry ; Male ; Muscle Fatigue ; drug effects ; Neurons ; drug effects ; pathology ; Oxidative Stress ; drug effects ; Physical Exertion ; Rats ; Rats, Wistar ; Vegetables ; chemistry

Mycoplasma pneumoniae encephalitis is one of the extrapulmonary complications of mycoplasma pneumoniae infectiontion children.The clinical diagnosis of mycoplasma pneumoniae encephalitis is difficult, so it is necessary to make stratified diagnosis based on the diagnosis of encephalopathy and the reliability of pathogen detection evidence.In addition to considering whether antibiotics are sensitive to mycoplasma pneumoniae, the selection of antibiotics should also consider the tissue penetration of antibiotics and the safety of children′s medication.These problems may lead to the delay in diagnosis as well as treatment of mycoplasma pneumoniae encephalitis in children and affect the prognosis of children.This paper intended to introduce and summarize the diagnosis of mycoplasma pneumoniae encephalitis and the selection principles and characteristics of main antibiotics for mycoplasma pneumoniae encephalitis, hoping to be helpful to clinicians.

Objective To discuss the mechanism,procedures and effect of implantable intrathecal infusion system for intractable pain therapy. Methods Among the 4 patients with intractable pain,2 had cancer pain,2 had failed back syndrome.Before operation,Visual Analogy Scale(VAS) were 8～10.Three had bolus intrathecal injection screening trial,1 had bolus epidural injection screening trial.In the clinical trail,VAS all decreased to 75%～90%.(Results) They all had intrathecal infusion system implantation.After operation,Morphine was prescribed(intrathecally.) The dose was 1～(8 mg).They all had satisfied pain relief without serious drug adverse effects.Conclusion The effect of implantable intrathecal system for intractable pain was satisfied.The drug adverse effects were obviously alleviated.

The treatment of chronic pain needs multidisciplinary management.Neurosurgical procedures hold an important role.With advancement in stereotactics,microsurgical and electrophysiological techniques,neurosurgical treatment becomes microinvasive,safer and popular.Neurosurgical procedures include anatomic,neuroaugmentative and neuroablative therapies.The procedure should be chosen individually.The pain characters,primary disorders,quality of life and survival time of the patient should be considered.A successful management must be well-indicated.