1.A network meta-analysis of treatment for newly diagnosed glioblastoma based on radiotherapy plus temozolomide
Mao-hua Zheng ; Hong-tao Sun ; Ji-guang Xu ; Yong-hong Zhang ; Gang Yang ; Lei-ming Huo ; Jin-hui Tian ; Ke-hu Yang ; Mao-hua Zheng ; Hong-tao Sun
Neurology Asia 2017;22(1):49-58
Background & Objective: Radiotherapy and temozolomide are the standard therapy for newly diagnosed
glioblastoma multiforme (GBM). However, it is unclear whether adding another agent to the commonly
used radiotherapy-temozolomide (RT + TMZ) benefits newly diagnosed GBM patients. The present
network meta-analysis aimed to assess the efficacy of combining other agents with RT + TMZ for
GBM treatment.
Methods: A comprehensive literature search was conducted on PubMed, EMBASE.com, Web of
Science, and the Cochrane Central Register of Controlled Trials from inception to September 23, 2014,
to include all randomized controlled trials of RT + TMZ-based therapy in GBM patients. Pairwise and
network meta-analyses were performed to compare the therapeutic regimens. Results: Seventeen studies
involving 4,148 patients were identified. The results of pairwise meta-analysis indicated no significant
differences among most comparison groups, except for bevacizumab + RT + TMZ versus RT + TMZ
for progression-free survival (hazard ratio [HR] = 0.71, 95% confidence interval [CI]: 0.59–0.86; P =
0.000) and RT + TMZ versus RT alone for overall survival (HR = 0.71, 95% CI: 0.58–0.88; P = 0.001).
The results of network meta-analysis also showed no significant differences in most comparisons;
however, adverse events were more common among patients receiving additional therapeutic agents
other than RT + TMZ. The ranking probability analysis indicated that bevacizumab + RT + TMZ and
nimustine + cisplatin + RT + TMZ were associated with the best progression-free and overall survival,
but they also caused the most adverse events in GBM patients. RT + bevacizumab + irinotecan had
the highest probability of being the best regimen for minimizing adverse events.
Conclusions: The addition of other targeted agents, particularly bevacizumab and nimustine, to
RT + TMZ could be slightly effective for the treatment of newly diagnosed GBM patients; however,
adverse events remained common.
Glioblastoma
2.Pharmacokinetic Features of Reactive Sulfide in Plasma of Rats After Oral Administration of Cinnabaris by Using HPLC Coupled with Pre-column Derivatization
Tao-Guang HUO ; Jing-Tan GUO ; Ying-Hua ZHANG ; Qiu LIU ; Zhong-Xing FU ; Hong JIANG ; Ting-Guo KANG
Chinese Journal of Information on Traditional Chinese Medicine 2018;25(3):86-89
Objective To study the pharmacokinetic features of reactive sulfide in rats after oral administration of Cinnabaris. Methods An HPLC coupled with precolumn derivatization method was developed for the pharmacokinetic features study on reactive sulfide in rats after oral administration of Cinnabaris. Results Good linearity (r>0.99) was found for reactive sulfide in plasma in the concentration range of 0.25–15 μmol/L (r>0.99). The LOQ and LOD of the method were 0.1 μmol/L and 0.02 μmol/L, respectively. The intra- and inter-day precision was less than 4.4% and 3.5% respectively, and the accuracy was -9.9%–6.0%. The average recovery rate was 74.9%. 0.6 g/kg Cinnabaris was given the rats for gavage, and the time-course pharmacokinetics parameters were as follows:Cmax(1.33±0.13) μmol/L, tmax(150±34) min, t1/2(323±62) min, AUC0-∞ (5743±297) ng/mL?h. Conclusion A sensitive, robust and accurate precolumn derivatization-HPLC method for the determination of plasma reactive sulfide is developed and validated. The method is successfully applied in the pharmacokinetic features study on reactive sulfide in plasma of rats after administration of Cinnabaris.
3.Quantitative T2 mapping evaluation for articular cartilage lesions in a rabbit model of anterior cruciate ligament transection osteoarthritis.
Zheng-mao WEI ; Xiang-ke DU ; Tian-long HUO ; Xu-bin LI ; Guang-nan QUAN ; Tian-ran LI ; Jin CHENG ; Wei-tao ZHANG
Chinese Medical Journal 2012;125(5):843-850
BACKGROUNDQuantitative T2 mapping has been a widely used method for the evaluation of pathological cartilage properties, and the histological assessment system of osteoarthritis in the rabbit has been published recently. The aim of the study was to investigate the effectiveness of quantitative T2 mapping evaluation for articular cartilage lesions of a rabbit model of anterior cruciate ligament transection (ACLT) osteoarthritis.
METHODSTwenty New Zealand White (NZW) rabbits were divided into ACLT surgical group and sham operated group equally. The anterior cruciate ligaments of the rabbits in ACLT group were transected, while the joints were closed intactly in sham operated group. Magnetic resonance (MR) examinations were performed on 3.0T MR unit at week 0, week 6, and week 12. T2 values were computed on GE ADW4.3 workstation. All rabbits were killed at week 13, and left knees were stained with Haematoxylin and Eosin. Semiquantitative histological grading was obtained according to the osteoarthritis cartilage histopathology assessment system. Computerized image analysis was performed to quantitate the immunostained collagen type II.
RESULTSThe average MR T2 value of whole left knee cartilage in ACLT surgical group ((29.05±12.01) ms) was significantly higher than that in sham operated group ((24.52±7.97) ms) (P=0.024) at week 6. The average T2 value increased to (32.18±12.79) ms in ACLT group at week 12, but remained near the baseline level ((27.66±8.08) ms) in the sham operated group (P=0.03). The cartilage lesion level of left knee in ACLT group was significantly increased at week 6 (P=0.005) and week 12 (P<0.001). T2 values had positive correlation with histological grading scores, but inverse correlation with optical densities (OD) of type II collagen.
CONCLUSIONThis study demonstrated the reliability and practicability of quantitative T2 mapping for the cartilage injury of rabbit ACLT osteoarthritis model.
Animals ; Anterior Cruciate Ligament ; metabolism ; physiopathology ; Cartilage, Articular ; metabolism ; physiopathology ; Collagen Type II ; metabolism ; Magnetic Resonance Imaging ; Male ; Osteoarthritis ; metabolism ; physiopathology ; Rabbits
4.Correlation between impaired glucose tolerance and carotid atberomatous plaque in patients with acute cerebral infarction
Guang-Lun ZENG ; Cheng-Guo ZHANG ; Guo-De LI ; Guo-Huo ZHANG ; Tao LIU ; Jian XIE ; Yan SHAO ; Shao-Hui LUO ; Wei-Ying PENG
Chinese Journal of Neuromedicine 2009;8(9):920-922
Objective To investigate the relationship between impaired glucose tolerance(IGT)and carotid atheromatous plague in patients with acute cerebral infarction and analyze the risk factors for plaque formation.Methods The 326 patients hospitalized in our department for acute cerebral infarction were divided into diabetes mellitus(DM)group,IGT group and normal glucose tolerance (NGT)group.The clinical features,biochemical indices and results of Doppler ultrasound examination of the carotid artery were compared between the 3 groups.Results The body mass index(BMI),total cholesterol(TC),and low-density lipoprotein cholesterol(LDL-C)of IGT group were markedly higher than those in NGT group(P<0.05).Both the IGT and DM group showed significantly increased carotid intimal-medial thickness,plaque detection rate and the incidence of carotid scleratheroma in comparison with the NGT group(P<0.05).Logistic regressive analysis identified age,TC,LDL-C and 2-h postprandial serum glucose as the independent risk factors for carotid scleratheroma.Conclusion In patients with acute cerebral infarction,those having impaired glucose often show obvious carotid scleratheroma with a severity similar to that in the DM patients.
6.An ambispective cohort study of the natural history of HIV infection among former unsafe commercial blood and plasma donors.
Fu-jie ZHANG ; Zhi-hui DOU ; Lan YU ; Ye MA ; Ning WANG ; Guang-hua CAO ; Chuan-tao LI ; Jin-xian ZHAO ; Xiang-dong MENG ; Xiao-chun QIAO ; Wei HUO ; Hong-xin ZHAO ; Zhong-fu LIU ; Lie WANG ; Hong SHANG
Chinese Journal of Epidemiology 2008;29(1):9-12
OBJECTIVEDiscussing the natural history and the influencing factors of HIV infection among former commercial blood and plasma donors engaged in unsafe blood donation practices in China.
METHODSUsing ambispective cohort study, with data obtained from ten counties (districts) from six provinces in the National AIDS Control Demonstration Area. HIV/AIDS cases were found and confirmed prior to July 24, 2006 being former commercial blood. Plasma donors were selected and data regarding infection, incidence, death, and influencing factors was collected. Analysis was performed using SPSS 12.0 statistical analysis software.
RESULTS(1) In 7551 cases of HIV infection, there were 6533 typical progressors (86.52%, 4757 cases of AIDS), 108 rapid progressors (1.43%), 910 long-term non-progressors (12.05%) with 4865 cases progressed to AIDS (64.43%). The median incubation period for HIV progression to AIDS was nine years (95% CI:8.96-9.04). (2) According to data, from a total of 1157 AIDS cases without ARV therapy (23.78% of total AIDS cases), there were 283 confirmed AIDS-related deaths, of which the median survival time was 6 months (95% CI:4-7) and the two and three year fatality rates were 95% and 99%, respectively. (3) The duration of HIV incubation period was irrespective to gender and age at the time of HIV infection (P > 0.05). Length of survival for untreated AIDS showed correlation to gender (P < 0.05) but no correlation with culture, marital status or age at the time of diagnosis of AIDS (P > 0.05).
CONCLUSIONCompared with the UNAIDS theory regarding slow disease progressors among adults, our study showed a longer AIDS incubation period and shorter outlook for untreated survival, but a similar incubation period for other routes of HIV infection.
Acquired Immunodeficiency Syndrome ; epidemiology ; mortality ; Adolescent ; Adult ; Aged ; Blood Donors ; statistics & numerical data ; China ; Female ; HIV Infections ; epidemiology ; mortality ; Humans ; Infectious Disease Incubation Period ; Male ; Middle Aged ; Young Adult
7.Effect of Arsenic in Realgar on Rat Ability in Novel Objects Recognition Test
Zhao YANG ; Jie-yu LIU ; Tao-guang HUO ; Gui-fan SUN ; Hong JIANG
Chinese Journal of Experimental Traditional Medical Formulae 2021;27(9):63-69
Objective:To determine the contents of inorganic arsenic(iAs),monomethylarsonic acid(MMA) and dimethylarsinic acid(DMA) in brain tissues and blood by using hydride generation-cold trap-atomic absorptionspectrometry(HG-CT-AAS), and to explore the toxic effects of Realgar on central nervous system of rats. Method:The 96 Wistar rats were randomly divided into 4 groups:normal control group,0.3,0.9 and 2.7 g·kg-1 Realgar groups. They then received intragastric administration for 14,28 and 42 days respectively, so a total of 12 groups were formed, with 8 animals in each group. The normal group was given the same dose of sodium carboxymethyl cellulose (CMC-Na) by gavage. The contents of iAs,MMA and DMA in blood and brain tissues were determined by HG-CT-AAS. The novel object recognition test was conducted to observe the learning and memory ability of rats. The changes of hippocampal neuron ultrastructure were observed by transmission electron microscopy. Result:There was no difference in the growth,weight and hippocampal coefficient of the experimental animals. The method of HG-CT-AAS showed a good linearity,precision,accuracy and recovery in content determination of arsenic (at various forms) in rat brain and blood. MMA and DMA were detected in the brain of realgar groups at time-dose-effect relationship. iAs,MMA and DMA were detected in the blood of Realgar groups. The nuclear membrane, mitochondria and endoplasmic reticulum in hippocampus neurons of rats were gradually damaged with the increase of Rhubarb exposure dose and time. After 14 days of exposure to Realgar,compared with the normal control group,there was no significant difference in the novel object recognition index among Realgar groups. After 28 days of exposure,only 2.7 g·kg-1 Realgar group showed statistically significant difference with the control group (
8.The Association between Educational Attainment and the Risk of Nonalcoholic Fatty Liver Disease among Chinese Adults: Findings from the REACTION Study
Yuanyue ZHU ; Long WANG ; Lin LIN ; Yanan HUO ; Qin WAN ; Yingfen QIN ; Ruying HU ; Lixin SHI ; Qing SU ; Xuefeng YU ; Li YAN ; Guijun QIN ; Xulei TANG ; Gang CHEN ; Shuangyuan WANG ; Hong LIN ; Xueyan WU ; Chunyan HU ; Mian LI ; Min XU ; Yu XU ; Tiange WANG ; Zhiyun ZHAO ; Zhengnan GAO ; Guixia WANG ; Feixia SHEN ; Xuejiang GU ; Zuojie LUO ; Li CHEN ; Qiang LI ; Zhen YE ; Yinfei ZHANG ; Chao LIU ; Youmin WANG ; Shengli WU ; Tao YANG ; Huacong DENG ; Lulu CHEN ; Tianshu ZENG ; Jiajun ZHAO ; Yiming MU ; Weiqing WANG ; Guang NING ; Yufang BI ; Yuhong CHEN ; Jieli LU
Gut and Liver 2024;18(4):719-728
Background/Aims:
Low educational attainment is a well-established risk factor for nonalcoholic fatty liver disease (NAFLD) in developed areas. However, the association between educational attainment and the risk of NAFLD is less clear in China.
Methods:
A cross-sectional study including over 200,000 Chinese adults across mainland China was conducted. Information on education level and lifestyle factors were obtained through standard questionnaires, while NAFLD and advanced fibrosis were diagnosed using validated formulas. Outcomes included the risk of NAFLD in the general population and high probability of fibrosis among patients with NAFLD. Logistic regression analysis was employed to estimate the risk of NAFLD and fibrosis across education levels. A causal mediation model was used to explore the potential mediators.
Results:
Comparing with those receiving primary school education, the multi-adjusted odds ratios (95% confidence intervals) for NAFLD were 1.28 (1.16 to 1.41) for men and 0.94 (0.89 to 0.99) for women with college education after accounting for body mass index. When considering waist circumference, the odds ratios (95% CIs) were 0.94 (0.86 to 1.04) for men and 0.88 (0.80 to 0.97) for women, respectively. The proportions mediated by general and central obesity were 51.00% and 68.04% for men, while for women the proportions were 48.58% and 32.58%, respectively. Furthermore, NAFLD patients with lower educational attainment showed an incremental increased risk of advanced fibrosis in both genders.
Conclusions
In China, a low education level was associated with a higher risk of prevalent NAFLD in women, as well as high probability of fibrosis in both genders.
9.A Clinicopathological Study on Stage I Ovarian Adult Granulosa Cell Tumors with Recurrence within 5 Years.
Zhen HUO ; Li-Na GUO ; Xiao-Hua SHI ; Zhi-Yong LIANG ; Jin-Hui WANG ; Xu-Guang LIU ; Tao LU ; Jun-Yi PANG
Chinese Medical Journal 2018;131(23):2877-2879
Adult
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Female
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Granulosa Cell Tumor
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metabolism
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pathology
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Humans
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Male
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Middle Aged
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Ovarian Neoplasms
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metabolism
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pathology
10.Chinese Trauma Surgeon Association for management guidelines of vacuum sealing drainage application in abdominal surgeries-Update and systematic review.
Yang LI ; Pei-Yuan LI ; Shi-Jing SUN ; Yuan-Zhang YAO ; Zhan-Fei LI ; Tao LIU ; Fan YANG ; Lian-Yang ZHANG ; Xiang-Jun BAI ; Jing-Shan HUO ; Wu-Bing HE ; Jun OUYANG ; Lei PENG ; Ping HU ; Yan-An ZHU ; Ping JIN ; Qi-Feng SHAO ; Yan-Feng WANG ; Rui-Wu DAI ; Pei-Yang HU ; Hai-Ming CHEN ; Ge-Fei WANG ; Yong-Gao WANG ; Hong-Xu JIN ; Chang-Ju ZHU ; Qi-Yong ZHANG ; Biao SHAO ; Xi-Guang SANG ; Chang-Lin YIN
Chinese Journal of Traumatology 2019;22(1):1-11
Vacuum sealing drainage (VSD) is frequently used in abdominal surgeries. However, relevant guidelines are rare. Chinese Trauma Surgeon Association organized a committee composed of 28 experts across China in July 2017, aiming to provide an evidence-based recommendation for the application of VSD in abdominal surgeries. Eleven questions regarding the use of VSD in abdominal surgeries were addressed: (1) which type of materials should be respectively chosen for the intraperitoneal cavity, retroperitoneal cavity and superficial incisions? (2) Can VSD be preventively used for a high-risk abdominal incision with primary suture? (3) Can VSD be used in severely contaminated/infected abdominal surgical sites? (4) Can VSD be used for temporary abdominal cavity closure under some special conditions such as severe abdominal trauma, infection, liver transplantation and intra-abdominal volume increment in abdominal compartment syndrome? (5) Can VSD be used in abdominal organ inflammation, injury, or postoperative drainage? (6) Can VSD be used in the treatment of intestinal fistula and pancreatic fistula? (7) Can VSD be used in the treatment of intra-abdominal and extra-peritoneal abscess? (8) Can VSD be used in the treatment of abdominal wall wounds, wound cavity, and defects? (9) Does VSD increase the risk of bleeding? (10) Does VSD increase the risk of intestinal wall injury? (11) Does VSD increase the risk of peritoneal adhesion? Focusing on these questions, evidence-based recommendations were given accordingly. VSD was strongly recommended regarding the questions 2-4. Weak recommendations were made regarding questions 1 and 5-11. Proper use of VSD in abdominal surgeries can lower the risk of infection in abdominal incisions with primary suture, treat severely contaminated/infected surgical sites and facilitate temporary abdominal cavity closure.
Abdomen
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surgery
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China
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Drainage
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methods
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Evidence-Based Medicine
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Humans
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Practice Guidelines as Topic
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Societies, Medical
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organization & administration
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Surgical Wound Infection
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prevention & control
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Traumatology
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organization & administration
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Vacuum