This paper probes into the scientific research management at a teaching hospital,where three responsibilities are required in clinical service,medical education and research.The staffs＇ need for scientific research is discussed base on Maslow＇s need-hierarchy theory.An incentive system is also proposed for research and professional development of the hospital.

Abstract： Objective　To analyze the changes of cytokine levels in patients with sensitive pulmonary tuberculosis and drug-resistant pulmonary tuberculosis before and after anti-tuberculosis treatment. Methods　The clinical data of 213 pulmonary tuberculosis patients admitted to the Eighth Affiliated Hospital of Xinjiang Medical University from August 2019 to October 2020 were collected, and divided into a sensitive pulmonary tuberculosis group and a drug-resistant pulmonary tuberculosis group, of which 141 were in the sensitive group and 72 in the drug-resistant group , and the pro-inflammatory factors tumor necrosis factor-α (TNF-α), IL-6, IL-17, interferon-γ (IFN-γ) and anti-inflammatory factors IL-10 and IL-4 in plasma before treatment, 3 months and 6 months after treatment were compared. Results　Compared with the healthy group, the levels of plasma IL-6 in the sensitive group and the resistant group were significantly increased, difference was statistically significant (P<0.01). The plasma levels of IFN-γ and IL-17 in the sensitive group were increased, and the difference was statistically significant (P<0.05). Compared with before treatment, the levels of IL-6 and IL-4 in the plasma of the sensitive group after 6 months of treatment were lower than those after 3 months of treatment, and the difference was statistically significant (P<0.05), and IFN-γ was significantly decreased (P<0.001). After 6 months of treatment, the IL-10 content was lower than that before treatment, and the difference was statistically significant (P<0.05), and the IFN-γ decreased significantly (P<0.000 1). The levels of IFN-γ at 3 months were higher than those in the resistant group, and the difference was statistically significant (P<0.01). After 6 months of treatment, there was no significant difference in the content of IFN-γ between the sensitive group and the resistant group. The effective rate of CT absorption was 70% in the sensitive group and only 43.33% in the resistant group at 3 months of treatment, and there was no significant difference in the effective rate between the two groups after 6 months of treatment. Conclusions　Detection of pro-inflammatory cytokines and anti-inflammatory cytokines in plasma can provide reference for host-directed therapy of pulmonary tuberculosis. Understanding this important feature of cytokines on pathogen-host interactions can provide new insights into the study of virulence mechanisms and may provide new approaches for immune intervention in pulmonary tuberculosis.

[Objective] To observe the effect of Leweiyin of traditional Chinese compounds prescription on gastrointestinal hormones and oxygen free radicals in IBS rabbits of spleen deficiency,and to explore the possible mechanism for the treatment of IBS with spleen deficiency.[Methods] 36 two-month-old rabbits with white feather and black eyes(WHBE rabbit),half male and half female,were randomly divided into 6 groups:normal group,model group,Xiangsha Liujun pill group,Lizhu Changle group,low-dose Leweiyin-treated group,high-dose Leweiyin-treated group.Except the normal group,others were made into IBS model of spleen deficiency which was induced by damp heat stress and gavage with Fanxieye as well as method of either hunger or gorge.The drug groups were administered preventively from the medium-term of the model reproduction to the end of modeling.The rabbits of each group were observed.NO,NOS,MDA,SOD in serum and SP in colonic membrane were detected.[Results] NO,NOS,MDA in serum and SP in colonic membrane significantly more increased than the normal group(P

AIM: Firstly to evaluate the changes of corneal sensation and its effect to dry eye syndrome after laser in situ keratomileusis (LASIK); secondly to evaluate the relation between the changes of corneal sensation and the laser ablation depth. ·METHODS: 30 patients (60 eyes) had bilateral LASIK with a superior-hinged flap. Every patient underwent preoperative and postoperative (after one week, one month and three months) evaluations, including corneal sensation, Schirmer's basic tear secretion test, tear breakup time (TBUT), corneal fluorescein stainting, and a questionnaire evaluating dry eye obtained from each patient.·RESULTS: Compared with preoperative level, after one week and one month, the difference of corneal sensation was very significant (P＜ 0.01); after three months, there was no statistical difference (P ＞ 0.05). After one week, there was no statistical difference (P ＞ 0.05) in the subjective dry eye symptoms, after one month, the difference was significant(P=0.025 ＜0.05) and after three months, the difference was very significant (P=0.001 ＜ 0.01). Compared with preoperative level, the basic tear secretion decreased significantly after one week and one month(P＜ 0.01), it did not return to the baseline level after three months (P ＜ 0.01). Tear breakup time decreased significantly after the surgery, and after three months, there was still statistical difference compared with preoperative level (P ＜ 0.01); with cornea fluorescence staining, we found corneal epithelial defect was most serious after one month after LASIK, and did not return to the baseline level after three months (P ＜ 0.01). Linear regression analysis and relevant were used to evaluate the relation between the changes of corneal sensation and the laser ablation depth (r=0.798, P ＜ 0.01). ·CONCLUSION: The central corneal sesation decreased noticeable after LASIK, and it recovered three months postoperatively, but the indicators of dry eye syndrome did not return to their preoperative levels following it. We have found that the decreasation of corneal sensation had positive correlation with the laser ablation depth.

ObjectiveTo explore whether the biocompatibility of phosphorylcholine (PC) modified alginate-chitosan microcapsules could be improved. MethodsPC modified alginate-chitosan microcapsules were obtained by high-voltage electrostatic system.Bradford method was adopted to determine the adsorption amounts of bovine serum albumin by chitosan alone and PC modified chitosan.Alginate-chitosan-PC microcapsules (experimental group) and alginate-chitosan microcapsules ( control group) were respectively implanted into the peritoneal cavity of mice and retrieved 4 weeks after transplantation.Fibrosis of the capsules was evaluated by HE staining.Glucose stimulated insulin secretion (GSIS) assay was used to assess the insulin secretion response of encapsulated and nonencapsulated rat islets. Results The adsorption amount of protein was 189.4 μg/mg and 90.5 μg/mg respectively by chitosan alone and PC modified chitosan.The difference had statistical significance ( t =5.549, P ＜ 0.05 ).In contrast to the control group, the cellular reaction on the surface of the modified microcapsules was weaker, with no obvious fibrosis found.The insulin secreted by encapsulated islets and nonencapsulated islets was( 3.298 ± 1.680 ) μIU/ml VS (4.299 ± 1.159 ) μIU/ml ( t =1.096, P ＞ 0.05 ) in response to low-glucose stimulus and( 11.783 ± 4.175 ) μIU/ml VS ( 12.875 ± 2.268 ) μIU/ml ( t =0.514, P ＞ 0.05 ) in response to high-glucose stimulus.Conclusions PC can improve the biocompatibility of alginate-chitosan microcapsules, with no effect on the biological function of encapsulated islets.It may be more appropriate to use modified microcapsules encapsulating islets for transplantation.

The HER-2/neu gene, also named c-erbB-2 or erbB-2, is proto-oncogene of v-erbB-2 which was firstly discovered in 1985. Many studies have been reported since that amplification of the HER-2 gene in breast tumors is associated with poor prognosis was recognized. The relevant knowledge of HER-2/neu gene is summarized in this article.

Adult ; Female ; Humans ; Lacrimal Apparatus ; immunology ; Lymphocytes ; immunology ; Male ; Mucous Membrane ; immunology

Vascular perfusion distribution in fibroids contrast-enhanced ultrasound images provides useful pathological and physiological information, because the extraction of the vascular perfusion area can be helpful to quantitative evaluation of uterine fibroids blood supply. The pixel gray scale in vascular perfusion area of fibroids contrast-enhanced ultrasound image sequences is different from that in other regions, and, based on this, we proposed a method of extracting vascular perfusion area of fibroids. Firstly, we denoised the image sequence, and then we used Brox optical flow method to estimate motion of two adjacent frames, based on the results of the displacement field for motion correction. Finally, we extracted vascular perfusion region from the surrounding background based on the differences in gray scale for the magnitude of the rich blood supply area and lack of blood supply area in ultrasound images sequence. The experimental results showed that the algorithm could accurately extract the vascular perfusion area, reach the precision of identification of clinical perfusion area, and only small amount of calculation was needed and the process was fairly simple.
Algorithms ; Contrast Media ; Female ; Humans ; Leiomyoma ; blood supply ; diagnostic imaging ; Motion ; Perfusion ; Ultrasonography

Aged ; Atrophic Vaginitis ; drug therapy ; Capsules ; Drug Therapy, Combination ; Drugs, Chinese Herbal ; administration & dosage ; therapeutic use ; Female ; Humans ; Middle Aged ; Suppositories ; administration & dosage ; Treatment Outcome

Objective To investigate the effects of Th17 cells and Treg cells on immune evasion in patients with hepatic hydatid disease. Methods From August 2008 to September 2009, 54 patients with hepatic hydatid disease who were treated at the First Affiliated Hospital of Xinjiang Medical University and 20 healthy people (control group) were enrolled in this study. Of the 54 patients, 21 had liver cystic enchinococcosis (CE)(CE group), 15 had recurrent cystic echinococcosis (RCE) (RCE group) and 18 had liver alveolar echinococcosis(AE) (AE group). The serum concentrations of interleukin-17 (IL-17), IL-23, transforming growth factor-β1(TGF-β1) and IL-10 were measured by enzyme-linked immunosorbent assay. All data were analysed by one-way analysis of variance, LSD-t test and Pearson correlation analysis. Results Serum IL-17 levels were significantlylower in the AE group [(11±3)ng/L], CE group [(13±4) ng/L] and RCE group [(13 ±5) ng/L]compared with those in the control group [(16±5) ng/L] ( F = 6.53, P ＜ 0.05 ). There was no significant difference in serum IL-17 levels between the CE and RCE groups (t =0.22, P ＞0.05). Serum levels of IL-23were also lower in the AE group [(72±27) ng/L], CE group [( 106±53) ng/L] and RCE group [( 107±48 ) ng/L] compared with those in the control group [( 139±50) ngg/L] ( F = 6.74, P ＜ 0.05 ), while there was no significant difference between the CE and RCE groups (t =0.02, P＞0.05). The serum levels of IL-10 were significantly higher in the AE group [(5.5±2.2) ng/L], CE group [(4.3±2.0) ng/L] and RCE group [(4.2 ± 1.4) ng/L] compared with those in the control group [(3.1 ± 0.8 ) ng/L] ( F = 9.78, P ＜ 0.05 ),with no significant differences between the CE and RCE groups ( t = 0.14, P ＞ 0.05 ). TGF-β1 levels were significantly higher in the AE group [(38±7) μg/L], CE group [(37±7) μg/L] and RCE group [(33±9) μg/L]compared with those in the control group [( 26±7) μg,/L] ( F = 6.73, P＜ 0.05 ), with no significant difference among the AE, CE and RCE groups ( t = 0.56, 1.81, P ＞ 0.05 ). The Th17/Treg (IL-17/IL-10) ratio was significantly decreased in the AE group ( 2.1 ± 0.7 ), CE group ( 3.6 ± 1.5 ) and RCE group ( 3.4 ± 1.9)compared with that in the control group (5.7 ± 2.6) ( F = 13.76, P ＜ 0.05 ), while no significant difference was found between the CE and RCE groups (t = 0.23, P ＞ 0.05). The serum concentrations of IL-17 were negatively correlated with TGF-β1 ( r = - 0.23, P ＜ 0.05 ) and positively correlated with IL-23 ( r = 0.70, P ＜ 0.05 ).Serum concentrations of IL-10 were positively correlated with TGF-β1 ( r = 0.46, P ＜ 0.05 ). Conclusion The overwhelming expression of Treg related cytokines disrupts the Th17/Treg balance in patients with AE or CE,which may have a potential role in immune evasion in the progress of hydatid disease.