Objective To analyze the characteristics and related factors of the incidence of intestinal infectious diseases in children.Methods 180 children with intestinal infectious diseases who were treated from July 2012 to July 2015 in our hospital were radomly selected.Meanwhile,180 healthy children were randomly selected from pediatric hospital examination as control group.Then,according to the clinical data and epidemiological data of these children,the number of cases were compared,and these children were from different age,different regions and different types of infections.The incidence factors of univariate and multivariate Logistic analysis were compared.Results In terms of age,patients younger than 1 year of age were 105 cases,between the ages of 1 -3 years were 37 cases, patients older than 3 years were 38 cases,the proportion of younger than 1 year was 58.3%,the proportion of patients between 1 -3 years of age was 20.6%,the proportion of older than 3 years of age was 21.1%,the proportion of patients younger than 1 year of age compared with the proportion of patients with the other two groups had significant differences (P <0.05).In the area,117 cases were from rural areas and the incidence rate was 65.0%,63 cases were from the city,and the incidence rate of the city was 35.0%,which was significantly lower than the incidence of rural areas,the difference was statistically significant (P <0.05).On the type of infection,parenteral infection was 24 cases,bacterial infection was 75 cases,viral infection was 81 cases,parenteral infection rate was 13.3%,bacterial infection rate was 41.7%,virus infection rate was 45.0%,parenteral infection was significantly lower than the other two infection prevalence groups,the difference was statistically significant (P <0.05 ).After univariate analysis, observation and control groups were compared,showed that children washing their hands before meals,children washing their hands after stool,parents washing their hands after stool,no tableware disinfection,ground nails,indoor flies and intestinal infectious diseases in children were concerned (P <0.05).After multivariate Logistic analysis,OR values of no tableware disinfection and indoor flies were greater than 1,they were risk factors,and ground nails,OR value of children and children wash their hands before meals and after hand washing were less than 1,they were protective factors.Conclusion Pediatric intestinal infectious diseases mainly occur in infants less than 1 year old, and the incidence has temporal and spatial distribution,multiviral and bacterial infections,the analysis by the relevant factors,including age,time,space and infectious pathogens.And children washing their hands before meals,washing their hands after stool,parents washing their hands after stool,no tableware disinfection,ground nails,indoor flies and intestinal infectious diseases in children -related,but not sterilized tableware and interior flies belong to risk factors and attendance nails,children and children wash their hands before meals and after hand washing belong to protection factor.

The paper described the nature of talents with high potentials as a source of leaders,highlighting their features of uncertainty,relativity and opportunity.Authors presented their insights and experiences in developing such talents into leaders of the hospital,and hold that nurturing of such talents calls for systematic emphasis,competence models to identify them,building an environment for them to stand out,and building of an appraisal and incentive mechanism that is scientific and efficient.

Obstructive jaundice is a common disease of hepatobihary surgery,including malignant and benign ones whose treatment and prognosis are obviously different.Malignant obstructive jaundice is one of the dieseases with a worse curative effect,the surgical treatment of this disorder has made much progress in recent years.however there are also some points of disagreement.This acticle reviews the advances of the preoperative preparation,radical excision and palliative drainage in the surgical treatment of malignant obstructive jaundice by reviewing the pertiment literature of China and abroad of recent years.

Description of the significance of the team learning theory in building a learning hospital.Building a flat structure in a learning organization, catering to the inherent needs of the hospital and its staff in development, selection of training materials conductive to building common vision of the team, effective and interactive means of training, and team trainings that are objective-specific, level-specific, hatched and focused.All these practices maximize the effectiveness of team learning, bringing forth in the hospital desirable changes in concepts, behavior, culture and performance in the building of a learning hospital

Objective To look for a better way to assay vascular endothelial growth factor(VEGF) and explore the correlation of serum VEGF levels with platelet and leucocyte count in breast cancer by comparison of peripheral blood plasma, serum and P-APR. Methods Blood samples were obtained from 42 patients with breast cancer and 20 healthy volunteers. Serum, plasma and P-APR samples were analyzed for VEGF using a commercially available sandwich ELISA, and assayed for semiquantitative measurement using microplatereader. At the same time, samples were analyzed by hematology analyzer. Results The level of VEGF in peripheral blood positively correlated to platelet (health control group: r=0.424, P=0.063) and leucocyte (health control group: r=0.443, P=0.050). The difference in VEGF values of P-APR between the localized breast cancer group and the health control group was statistically significant. Conclusion The level of VEGF in peripheral blood positively correlates to platelet and leucocyte. Platelet and leucocyte possibly secrete VEGF in vitro. Compared with serum and plasma, P-APR is the best section assaying VEGF in peripheral blood.

Chemotherapy resist is the problem for clinic,and some researches find that chemotherapy with anthracycline and oxaliplatin not only induces the tumor cell apoptosis,but also the celt immunogenic cell death (ICD) by inducing the tumor cell apoptosis and releasing three kinds of signals:exposure of calreticulin on the cell surface to stimulate the dendritic cell (DC) to engulf,and the secretion of adenosine triphosphate to recruit DC to enter into tumor bed,and the release of the high mobility group B1 to promote DC to steadily bind with dying tumor cell to induce specific T cell antitumor immune response.It is with great meaning to promote the chemotherapy protocol by studying the ICD induced by chemotherapy.

Arrhythmia is common in cardiovascular diseases, especially after myocardial infarction. This article reviews the electrophysiologic changes following myocardial infarction at different phases. Modulations of ion channel function that might contribute to electrical remodeling, such as cellular (autocrine/paracrine) factors and regulators of ion channel gene, are discussed. Unresolved problems in ventricular electrical remodeling after myocardial infarction are also considered.

Pleomorphic adenoma (PA) is a rare benign tumor in the pharynx. We presented a case with a huge PA in the pharynx. MRI displayed oropharyngeal mass, considering benign tumor. Preoperative fine-needle aspiration and cytology biopsy were important to confirm the diagnosis of PA preliminary. Extracapsular complete dissection for PA was performed under general anesthesia with tracheotomy subsequently. Postoperative histopathological examination confirmed the diagnosis of PA. The patient was discharged a week after operation and no recurrence was found in the following 8 months.
Adenoma, Pleomorphic ; diagnosis ; surgery ; Biopsy, Fine-Needle ; Humans ; Magnetic Resonance Imaging ; Neoplasm Recurrence, Local ; Pharyngeal Neoplasms ; diagnosis ; surgery ; Pharynx

Objective:To investigate and compare the influences of Ghrelin and growth hormone releasing peptide 6(GHRP-6) on the contractility of stomach smooth muscle in guinea pigs,and to study the related mechanism.Methods: The myenteric plexuses of gastric fundus and antrium in guinea pigs were stimulated with electrical field stimulation(EFS) to observe the influence of Ghrelin and GHRP-6 on the contractility of stomach smooth muscle.The influences of N-nitro-L-arginine(L-NNA) and L-Arginine(L-AA) on the effect of Ghrelin and GHRP-6 were studied to disclose the mechanism of the effects of Ghrelin and GHRP-6.Results: The circular muscle tissues of the gastric fundus generated on-relaxations and off-contractions when stimulating myenteric plexuses with 1-16 Hz electrical field;the on-responses induced relaxation could be reduced by L-NNA and the off-contractions induced contraction could be blocked by atropine and guanethidine.In fundic strips,ghrelin and GHRP-6 could decrease the on-response induced relaxation and increase off-response induced contraction of the muscle,with the effect of Ghrelin obviously stronger than that of GHRP-6.L-NNA could increase the effects of Ghrelin and GHRP-6-induced muscle contraction,and L-AA could decrease their effects.In the antral strips,electrical field stimulation of myenteric plexuses led to disappearance of relaxation wave,only leaving off-contractions.Both ghrelin and GHRP-6 could increase that contraction.Conclusion: Both ghrelin and GHRP-6 can promote the contractility of stomach smooth muscle in guinea pigs through stimulating myenteric plexuses of gastric fundus and antrium,which might be related to the NO pathway.

Objective To investigate the expression of Semaphorin 3F (SEMA3F) protein in hepatocellular carcinoma (HCC) and to demonstrate its relationship with clinicopathological features and prognosis of HCC. Methods Western Blotting was carried out in 32 hepatocellular carcinoma samples and matched perineoplastic tissues to detect the expression of SEMA3F protein. The relationship between SEMA3F protein expression and clinicopathological features as well as prognosis of HCC patients was analyzed. Immunohistochemistry was used to show the location of SEMA3F in HCC cells and its relationship with microvessel density (MVD). Results The expression of SEMA3F protein in HCC tissues was significantly higher than in the perineoplastic tissues (447.78± 48.26 vs 618.93 ±61.23, P＜0. 05) and it was correlated closely with tumor capsulation and tumor nodular number (P＜0.05). Based on the Western Blotting and clinical follow-up data, we found that the survival time of HCC patients with a higher SEMA3F expression level was longer than those with a lower level, and the recurrent/metastatic time of HCC patients was significantly different between these two groups (P＜0.01). Immunohistochemistry demonstrated that SEMA3F protein localized in the cytoplasm of HCC cells and its expression correlated with HCC MVD. MVD in the low-level group was higher than the high-level group (115.6±30.38 vs 86. 56±17.94, P＜0.01). Conclusions SEMA3F expression in HCC was significantly down-regulated and correlated closely with tumor-capsulation, nodular number, and MVD, implicating SEMA3F may play an important role in recurrence and metastasis of HCC. It can be regarded as a prognostic marker in HCC patients.