Epilepsy is one of the most common neurological diseases, affecting about 70 million people worldwide, more than half of whom are children.Even though seizure-free is largely achieved by anti-seizure medications, there are still one-third of patients with epilepsy who continue to experience seizure attacks and develop into refractory epilepsy(RE). RE can seriously impair the life-quality of children and their families, and impose a substantial burden on society.Therefore, it is of great significance to explore and discover novel therapeutic methods and strategies for RE in children.This review is aimed to introduce several current and emerging therapeutic approaches for RE, including some new anti-seizure medications, ketogenic diet, neurosurgery, neurostimulation and emerging precision medicine, and provide new treatment strategy to children with RE.

Objective: To study the psychological and behavioral problems of children with tic disorders (TD), and to identify related influencing factors for effective medical intervention strategies. Methods: From June 2020 to June 2021, 69 children with TD were randomly selected as the case group in the pediatric neurologic clinic, while the control group included 69 healthy children who were matched by gender and age. The data were obtained through general questionnaire, Screen for Child Anxiety Related Emotional Disorders-41 (SCARED-41), Strengths and Difficulties Questionnaire-25 (SDQ-25) and the Children s Depression Inventory-Short Form (CDI-10), while psychological and behavioral problems and their related risk factors were analyzed. Results: The total scores of SCARED-41, SDQ-25 and its difficulties scale, and CDI-10 were (22.1±12.5,13.3±12.3) (21.1±6.0,15.9±3.4) ( 15.6± 6.3,9.3±3.6) (3.7±2.9,2.6±2.9) in the TD and control group respectively, with significant differences ( t/Z =3.8, 13.9, 6.9, -2.6, P <0.05). According to multiple linear regression of children in the TD group, statistically significant effects of maternal bachelor degree on SDQ-25 emotional symptoms, associate degree on SDQ-25 prosocial behavior ( B =-2.20, 2.14), lenient parenting attitude on SCARED-41 general anxiety, worry on SDQ-25 hyperactivity ( B =-7.44, 3.00), time spent on electronic devices on SCARED-41 somatic/panic, school phobia and SDQ-25 conduct problems ( B =0.49, 0.30, 0.20) and exercise intensity of small intensity on CDI-10 ( B =-0.15)were observed ( P <0.05). Conclusion Children with TD are prone to emotional disturbances such as anxiety, depression and behavioral problems, all of which are related to their mothers educational background, parents attitude towards discipline, the duration of electronic device use and exercise intensity.