OBJECTIVE: To explore the relationship between unexpected damage and clinical character, biological activities and molecular biology. METHODS: We treated 76 cases of children wilm's tumor from 1995 to 1998. Among them, 9 cases (11.8%) underwent unexpected damages. We studied and analyzed the clinical characters, clinical pathology, morphology and molecular biology in the 9 cases. RESULTS: Wilm's tumor in late stage, blastoma cell type and bad differentiation was likely to be damaged unexpectedly, and the outcome was poor. CONCLUSIONS: Mutation of gene is related to the biological activities. It may be a potential and important factor to cause unexpected damage.

Objective:To investigate the application value of fluorescence imaging in single-port thoracoscopic anatomic segmentectomy.Methods:The clinical data of 280 patients (145 patients with fluorescence method and 135 patients with modified inflation-deflation method) who underwent thoracoscopic anatomic segmentectomy were retrospectively studied in the Anhui Chest Hospital from June 2020 to June 2021. There were 113 patients in the simple segmentectomy group and 167 patients in the complex segmentectomy group. The baseline data of the fluorescence method and the modified inflation-deflation method in the complex segmentectomy group were corrected by propensity score matching, and the perioperative results were compared between the groups.Results:There were no significant differences in segmental resection time, intraoperative blood loss, postoperative drainage, postoperative pain, postoperative extubation time, length of hospital stay, incidence of complications and cost of hand-holding between the fluorescence method and the modified method of the simple segmentectomy group.In the complex segmentectomy group, the time of segmental resection with the fluorescence method was significantly shorter than that with the modified inflation-deflation method( P<0.05), and other indexes had no significant difference. Conclusion:Fluorescence method single-port thoracoscopic anatomic segmentectomy has the same perioperative safety and short-term efficacy as modified inflation-deflation method, which can significantly shorten the operative time and improve the operative efficiency in complex anatomic segmentectomy.