1.Tumor angiogenesis related to growth pattern and lymph node metastasis in early gastric cancer
Xiangming CHE ; Hokita SHUICHI ; Natsugoe SHOJI ; Tanabe GEN ; Baba MASAMICHI ; Takao SONSHIN ; Aikou TAKASHI
Chinese Medical Journal 1998;(12):1090-1093
Objective To investigate the correlation between angiogenesis and tumor growth pattern as well as the lymph node metastasis to reveal the significance of vascularity in the early stage of gastric cancer.Methods 97 specimens from patients with early gastric cancer were studied by immunohistochemical method using anti-factor Ⅷ related antigen antibody.Results Microvessel count was related to tumor growth pattern. The mean vessel count was higher in superficially spreading and penetrating types of tumors. Lymph node metastasis was correlated to microvessel count. Tumors with lymph node metastasis had higher microvessel counts than those without lymph node metastasis.Conclusions In the early stage of gastric carcinoma, angiogenesis is correlated with tumor growth pattern and lymph node metastasis. Identification of tumors with high density of vascularization is beneficial for closer follow-up and adjuvant therapy.
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